The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
MicroRNA-23a promotes myelination in the central nervous system
Open accessAbstract
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment. Overexpression of lamin B1 leads to leukodystrophy characterized by demyelination of the central nervous system, and microRNA-23 (miR-23) was found to suppress lamin B1 and enhance oligodendrocyte differentiation in vitro. Here, we demonstrated that miR-23a-overexpressing mice have increased myelin thickness, providing in vivo evidence that miR-23a enhances both oligodendrocyte differentiation and myelin synthesis. Using this mouse model, we explored possible miR-23a targets and revealed that the phosphatase and tensin homologue/phosphatidylinositol trisphosphate kinase/Akt/mammalian target of rapamycin pathway is modulated by miR-23a. Additionally, a long noncoding RNA, 2700046G09Rik, was identified as a miR-23a target and modulates phosphatase and tensin homologue itself in a miR-23a-dependent manner. The data presented here imply a unique role for miR-23a in the coordination of proteins and noncoding RNAs in generating and maintaining healthy myelin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“it can inhibit the expression of lamin B1 to protect against leukodystrophy characterized by demyelination of the central nervous system.”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [134]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Experimental loss of miR-23a reduces myelin gene expression and increases OL susceptibility to stress (Lin et al., 2013).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Lin et al., 2013
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While direct AD-specific data for miR-23a/b remain limited, converging transcriptomic studies consistently report dysregulation of myelin-regulatory pathways in AD white matter, suggesting indirect relevance within OL-mediated degeneration (Nasrabady et al., 2018; Lin et al., 2013; Zhou et al., 2022).”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Lin et al., 2013
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“LncRNA 2700046G09Rik was targeted by miR-23a to modulate phosphatase and tensin homolog and maintain normal myelin function [133,134].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [134]
The cited source says what the claim attributes to it.
In the citing paper
“overexpressing miR-23a in mice was observed as the thickness of myelin increases”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [134]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The hsa-miR-221/222 family, involved in neuroinflammation [49][50][51] , was enriched both in neurons and microglia (Supplementary Figure 2e).”
From Human brain microRNAs exhibit cell-type specificity and age dependence (2026) · cites this paper as [49]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Furthermore, miR-23a/b is required for maintaining OPC and OL survival and nuclear integrity.”
From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Lin et al., 2013
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262
Molecular Mechanisms of Long Noncoding RNAs
Wang, K., & Chang, H. Y. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.018 · Cited by 4,462
Genome Regulation by Long Noncoding RNAs
Rinn, J. L., & Chang, H. Y. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051410-092902 · Cited by 4,091
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps
Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature · doi:10.1038/nature08170 · Cited by 1,791
Long Noncoding RNAs with Enhancer-like Function in Human Cells
Ørom, U. A., Derrien, T., Beringer, M., Gumireddy, K., Gardini, A., Bussotti, G., Lai, F., Zytnicki, M., Notredame, C., Huang, Q., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.001 · Cited by 1,721
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
Xu, N., Papagiannakopoulos, T. Y., Pan, G., Thomson, J. A., & Kosik, K. S. (2009) · Cell · doi:10.1016/j.cell.2009.02.038 · Cited by 1,160
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 1,001
Non-coding RNAs as regulators of embryogenesis
Pauli, A., Rinn, J. L., & Schier, A. F. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2904 · Cited by 637
Bace1 modulates myelination in the central and peripheral nervous system
Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience · doi:10.1038/nn1797 · Cited by 608
Junker, A., Krumbholz, M., Eisele, S., Mohan, H., Augstein, F., Bittner, R., Lassmann, H., Wekerle, H., Hohlfeld, R., & Meinl, E. (2009) · Brain · doi:10.1093/brain/awp300 · Cited by 595
Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
Dugas, J. C., Cuellar, T. L., Scholze, A., Ason, B., Ibrahim, A., Emery, B., Zamanian, J. L., Foo, L. C., McManus, M. T., & Barres, B. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.027 · Cited by 577
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
Qureshi, I., & Mehler, M. F. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3234 · Cited by 574
TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
Kato, M. V., Putta, S., Wang, M., Yuan, H., Lanting, L. L., Nair, I., Gunn, A., Nakagawa, Y., Shimano, H., Todorov, I., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1897 · Cited by 572
MicroRNAs: Novel Biomarkers for Human Cancer
Bartels, C. L., & Tsongalis, G. J. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.112805 · Cited by 538
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.-S., Xin, M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.018 · Cited by 508
Lamin B1 duplications cause autosomal dominant leukodystrophy
Padiath, Q. S., Saigoh, K., Schiffmann, R., Asahara, H., Yamada, T., Koeppen, A. H., Hogan, K. J., Ptáček, L. J., & Fu, Y. (2006) · Nature Genetics · doi:10.1038/ng1872 · Cited by 407
Self-citationLong noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation
Mercer, T. R., Qureshi, I., Gökhan, Ş., Dinger, M. E., Li, G., Mattick, J. S., & Mehler, M. F. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-14 · Cited by 396
Constitutively active Akt induces enhanced myelination in the CNS
Flores, A. I., Narayanan, S. P., Morse, E. N., Shick, H. E., Yin, X., Kidd, G., Avila, R. L., Kirschner, D. A., & Macklin, W. B. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0150-08.2008 · Cited by 361
Goebbels, S., Oltrogge, J. H., Kemper, R., Heilmann, I., Bormuth, I., Wolfer, S., Wichert, S. P., Möbius, W., Liu, X., Lappe-Siefke, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0219-10.2010 · Cited by 353
Control of oligodendrocyte differentiation by theNkx2.2homeodomain transcription factor
Qi, Y. B., Cai, J., Wu, Y., Wu, R., Lee, J. D., Fu, H. Q., Rao, M. S., Sussel, L., Rubenstein, J. L. R., & Qiu, M. S. (2001) · Development · doi:10.1242/dev.128.14.2723 · Cited by 351
Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination
Narayanan, S. P., Flores, A. I., Wang, F., & Macklin, W. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0232-09.2009 · Cited by 328
The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation
He, Y., Dupree, J. L., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., & Casaccia‐Bonnefil, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.029 · Cited by 272
Tyler, W. A., Gangoli, N., Gokina, P., Kim, H. A., Covey, M., Levison, S. W., & Wood, T. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0234-09.2009 · Cited by 263
Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes
Lau, P., Verrier, J. D., Nielsen, J. A., Johnson, K. R., Notterpek, L., & Hudson, L. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1932-08.2008 · Cited by 252
miR-23regulation of lamin B1 is crucial for oligodendrocyte development and myelination
Lin, S., & Fu, Y. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001065 · Cited by 174
Self-citationOligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination
Harrington, E. P., Zhao, C., Fancy, S. P. J., Kaing, S., Franklin, R. J. M., & Rowitch, D. H. (2010) · Annals of Neurology · doi:10.1002/ana.22090 · Cited by 163
Control of oligodendroglial cell number by the miR-17-92 cluster
Budde, H., Schmitt, S., Fitzner, D., Opitz, L., Salinas-Riester, G., & Simons, M. (2010) · Development · doi:10.1242/dev.050633 · Cited by 152
Decapping of Long Noncoding RNAs Regulates Inducible Genes
Geisler, S. J., Lojek, L. J., Khalil, A. M., Baker, K. E., & Coller, J. M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.11.025 · Cited by 133
Tan, X., Wang, S., Zhu, L., Wu, C., Yin, B., Zhao, J., Yuan, J., Qiang, B., & Peng, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207787109 · Cited by 121
Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy
Goebbels, S., Oltrogge, J. H., Wolfer, S., Wieser, G. L., Nientiedt, T., Pieper, A. A., Ruhwedel, T., Groszer, M., Sereda, M. W., & Nave, K. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200227 · Cited by 115
Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis
Ridolfi, E., Fenoglio, C., Cantoni, C., Calvi, A., Riz, M. A. D., Pietroboni, A. M., Villa, C., Serpente, M., Bonsi, R., Vercellino, M., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034375 · Cited by 89
β1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth
Barros, C. S., Nguyen, T., Spencer, K. S. R., Nishiyama, A., Colognato, H., & Müller, U. (2009) · Development · doi:10.1242/dev.038679 · Cited by 87
Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model
Heng, M. Y., Lin, S.-T., Verret, L., Huang, Y., Kamiya, S., Padiath, Q. S., Tong, Y., Palop, J. J., Huang, E. J., Ptácχek, L. J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66737 · Cited by 78
Self-citationPezzolesi, M. G., Zbuk, K. M., Waite, K. A., & Eng, C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm053 · Cited by 62
The transcriptional regulator Yin Yang 1 activates the myelin PLP gene
Berndt, J. A., Kim, J. G., Toŝić, M., Kim, C., & Hudson, L. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00307.x · Cited by 46
Unraveling Oligodendrocyte Origin and Function by Cell-Specific Transgenesis
Belachew, S. M., Yuan, X. Q., & Gallo, V. (2001) · Developmental Neuroscience · doi:10.1159/000048712 · Cited by 44
MicroRNAs are significantly influenced by p53 and radiation in HCT116 human colon carcinoma cells
An (2009) · International Journal of Oncology · doi:10.3892/ijo_00000295 · Cited by 40
Cited by
Sorted by citations
Liu, J., Fan, L., Yu, H., Zhang, J., He, Y., Feng, D., Wang, F., Li, X., Liu, Q., Li, Y., et al. (2019) · Hepatology · doi:10.1002/hep.30607 · Cited by 449
Emery, B., & Lu, Q. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020461 · Cited by 307
Molecular Control of Oligodendrocyte Development
Elbaz, B., & Popko, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.01.002 · Cited by 302
MicroRNAs in neural development: from master regulators to fine-tuners
Rajman, M., & Schratt, G. (2017) · Development · doi:10.1242/dev.144337 · Cited by 269
Li, Y., Liu, Z., Song, Y., Pan, J.-J., Jiang, Y., Shi, X., Liu, C., Ma, Y., Luo, L., Mamtilahun, M., et al. (2022) · Theranostics · doi:10.7150/thno.68895 · Cited by 152
Metadata
- Authors
- Lin, S.-T., Huang, Y., Zhang, L., Heng, M. Y., Ptáček, L. J., & Fu, Y.-H.
- Affiliations
- Department of Neurology and
- Howard Hughes Medical Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-10-07
- Volume
- 110
- Issue
- 43
- Pages
- 17468-17473
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3808585
- OpenAlex
- W2071512787
- Cited by
- 117
- References
- 39
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 13 · 2019: 20 · 2018: 3 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 8
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063720)
- National Institute of Neurological Disorders and Stroke (NS062733, R01NS062733)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- microRNA-23a, myelination, oligodendrocyte differentiation, lamin B1, leukodystrophy, demyelination, myelin synthesis, microRNA target regulation, central nervous system
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Central Nervous System, Humans, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Myelin Sheath, Oligodendroglia, Blotting, Western, Signal Transduction, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Proto-Oncogene Proteins c-akt, PTEN Phosphohydrolase, Mice, HEK293 Cells, TOR Serine-Threonine Kinases, Transcriptome, RNA, Long Noncoding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
