The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Bioavailable copper modulates oxidative phosphorylation and growth of tumors
Open accessAbstract
Significance: This paper describes the mechanism by which copper mediates the interplay between the two energy-producing pathways, respiration and glycolysis. Many tumors produce increased levels of lactate, even when oxygen abounds, reflecting aerobic glycolysis (“Warburg effect”), whereas most normal tissues solely use respiration. We demonstrate that reducing systemic copper with a chelating drug impaired mitochondrial energy metabolism and decreased ATP levels despite induction of glycolysis. We propose that the metabolic phenotype of tumors is modulated in part by variable levels of copper in tumor microenvironment. Our work identifies copper as a tumor promoter by demonstrating that chronic exposure to elevated levels of copper in drinking water—to the maximum allowed in public water supplies—accelerates tumor growth in mice.
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Cites
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Warburg, O. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,468
Metformin and reduced risk of cancer in diabetic patients
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Self-citationMechanisms for copper acquisition, distribution and regulation
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Cited by
Copper homeostasis and cuproptosis in health and disease
Chen, L., Min, J., & Wang, F. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01229-y · Cited by 1,493
Connecting copper and cancer: from transition metal signalling to metalloplasia
Ge, E. J., Bush, A. I., Casini, A., Cobine, P. A., Cross, J. R., DeNicola, G. M., Dou, Q. P., Franz, K. J., Gohil, V. M., Gupta, S., et al. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00417-2 · Cited by 1,298
Synthetic fluorescent probes for studying copper in biological systems
Cotruvo, Jr., Aron, A. T., Ramos-Torres, K. M., & Chang, C. J. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00346b · Cited by 558
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Selective Targeting of Cancer Cells by Copper Ionophores: An Overview
Oliveri, V. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.841814 · Cited by 367
Metadata
- Authors
- Ishida, S., Andreux, P., Poitry-Yamate, C., Auwerx, J., & Hanahan, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-11
- Volume
- 110
- Issue
- 48
- Pages
- 19507-19512
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2125642839
- Cited by
- 422
- References
- 44
- FWCI
- 14.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Ishida, S., Andreux, P., Poitry-Yamate, C., Auwerx, J., & Hanahan, D. (2013). Bioavailable copper modulates oxidative phosphorylation and growth of tumors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1318431110
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
