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Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices

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Chandler, Daniel J., Gao, Wen-Jun, Waterhouse, Barry D.·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1320827111PMC PMC4020069

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Abstract

Significance: The locus coeruleus projection system in the brain is thought to exert uniform and synchronous modulatory effects on cells and circuits throughout the CNS by widespread release of its transmitter, norepinephrine. We challenge this notion by demonstrating that neurons in the locus coeruleus maintain segregated connections to brain regions with distinctly different functions. Specifically, cells that communicate with the prefrontal cortex, a region involved in cognition and executive function, are characterized by properties that allow for independent and asynchronous modulation of operations in this area, compared with those that project to the motor cortex and regulate movement generation. These findings have important implications for understanding the role of this system in normal brain physiology and pathologic neuropsychiatric conditions.

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Author Response: Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during behavior and learning
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Reviewer #2 (Public Review): Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments
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eLife Assessment: Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments
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Author response: Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments
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Authors: Chandler, D. J., Gao, W.-J., & Waterhouse, B. D.
Affiliations: Drexel University (US)
ORCID: Chandler, Daniel J.
Gao, Wen-Jun
Waterhouse, Barry D.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-04-21
Volume: 111
Issue: 18
Pages: 6816-6821
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1320827111
PMC: PMC4020069
OpenAlex: W2109682741
Cited by: 341
References: 45
Citations by year: 2026: 41 · 2025: 35 · 2024: 36 · 2023: 28 · 2022: 31 · 2021: 24 · 2020: 32 · 2019: 26 · 2018: 25 · 2017: 23 · 2016: 16 · 2015: 23 · 2014: 1
FWCI: 9.60
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Rowan Digitals Works (Rowan University) (submittedVersion)
Funders: National Institute of Mental Health (R01MH085666, R01MH101178)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: locus coeruleus, norepinephrine, prefrontal cortex, motor cortex, efferent projections, neuronal heterogeneity, noradrenaline release, noradrenergic neurons, adaptive and maladaptive behavior
MeSH terms: Animals, Behavior, Animal, Efferent Pathways, Locus Coeruleus, Male, Motor Cortex, Norepinephrine, RNA, Messenger, Tyrosine 3-Monooxygenase, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, AMPA, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Principal Component Analysis, Vesicular Monoamine Transport Proteins, Rats, Voltage-Gated Sodium Channel beta-3 Subunit

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Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices

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