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Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices
Open accessAbstract
Significance: The locus coeruleus projection system in the brain is thought to exert uniform and synchronous modulatory effects on cells and circuits throughout the CNS by widespread release of its transmitter, norepinephrine. We challenge this notion by demonstrating that neurons in the locus coeruleus maintain segregated connections to brain regions with distinctly different functions. Specifically, cells that communicate with the prefrontal cortex, a region involved in cognition and executive function, are characterized by properties that allow for independent and asynchronous modulation of operations in this area, compared with those that project to the motor cortex and regulate movement generation. These findings have important implications for understanding the role of this system in normal brain physiology and pathologic neuropsychiatric conditions.
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“Indeed, a subset of locus coeruleus neurons project selectively to PFC50, which may accentuate the stress response in this region.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [50]
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Metadata
- Authors
- Chandler, D. J., Gao, W.-J., & Waterhouse, B. D.
- Affiliations
- Drexel University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-21
- Volume
- 111
- Issue
- 18
- Pages
- 6816-6821
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4020069
- OpenAlex
- W2109682741
- Cited by
- 341
- References
- 45
- Citations by year
- 2026: 41 · 2025: 35 · 2024: 36 · 2023: 28 · 2022: 31 · 2021: 24 · 2020: 32 · 2019: 26 · 2018: 25 · 2017: 23 · 2016: 16 · 2015: 23 · 2014: 1
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rowan Digitals Works (Rowan University) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH085666, R01MH101178)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- locus coeruleus, norepinephrine, prefrontal cortex, motor cortex, efferent projections, neuronal heterogeneity, noradrenaline release, noradrenergic neurons, adaptive and maladaptive behavior
- MeSH terms
- Animals, Behavior, Animal, Efferent Pathways, Locus Coeruleus, Male, Motor Cortex, Norepinephrine, RNA, Messenger, Tyrosine 3-Monooxygenase, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, AMPA, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Principal Component Analysis, Vesicular Monoamine Transport Proteins, Rats, Voltage-Gated Sodium Channel beta-3 Subunit
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