Cited by 147Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesFunctional Brain Connectivity Studies

Regional cerebral metabolic patterns demonstrate the role of anterior forebrain mesocircuit dysfunction in the severely injured brain

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Fridman, Esteban A., Beattie, Bradley J., Broft, Allegra, Laureys, Steven, Schiff, Nicholas D.·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: Establishing consciousness in the human brain requires an ensemble activity of multiple cortical and subcortical structures. Following severe brain injuries, widespread deafferentation and neuronal death alter function across the corticothalamic system and its projections to the basal ganglia. In this paper, we test a theoretical model of a mesocircuit mechanism likely to arise in all severe brain injuries. Specifically, reduction of resting glucose metabolism within the central thalamus, striatum, and frontoparietal cortices and concomitant increases in metabolism within the globus pallidus as a result of disinhibition are proposed to arise across etiologies of injury. Here we verify this prediction and demonstrate a reversal of metabolic profile of central thalamus and globus pallidus that characterizes and indexes the patients’ behavioral level.

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  1. [49]49. Giacino JT, Kalmar K, Whyte J (2004) The JFK Coma Recovery Scale-Revised: Mea- surement characteristics and diagnostic utility. Arch Phys Med Rehabil 85(12):2020-2029.

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Authors
Fridman, E. A., Beattie, B. J., Broft, A., Laureys, S., & Schiff, N. D.
Affiliations
  • Weill Cornell Medicine (US)
  • Memorial Sloan Kettering Cancer Center (US)
  • Columbia University Irving Medical Center (US)
  • University of Liège (BE)
Venue
Proceedings of the National Academy of Sciences
Published
2014-04-14
Volume
111
Issue
17
Pages
6473-6478
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1993492847
Cited by
147
References
55
Citations by year
2026: 10 · 2025: 11 · 2024: 19 · 2023: 15 · 2022: 12 · 2021: 11 · 2020: 4 · 2019: 11 · 2018: 22 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 5
FWCI
8.08
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
Funders
  • James S. McDonnell Foundation
  • National Institutes of Health (HD51912)
  • National Institute of Child Health and Human Development
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD051912, 1R01-HD51912)
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
disorders of consciousness, severe brain injury, central thalamus, globus pallidus, striatum, deafferentation, frontoparietal network, regional cerebral glucose metabolism, command following, consciousness recovery
MeSH terms
Brain Injuries, Demography, Female, Glucose, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Rest, Case-Control Studies, Cerebrum

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