Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice
Open accessAbstract
Midbrain dopaminergic activity seems to be important in forming the prediction of future events such as rewards. The nucleus accumbens (NAc) plays an important role in the integration of reward with motor function, and it receives dense dopamine innervation and extensive limbic and cortical afferents. Here, we examined the specific role of the dopamine D2 receptor (D2R) in mediating associative learning, locomotor activity, and regulating NAc neural responses by using D2R-knockout (KO) mice and their wild-type littermates. D2R-KO mice displayed reduced locomotor activity and slower acquisition of a place-learning task. D2R-KO eliminated the prereward inhibitory response of neurons in the NAc. In contrast, an increased number of neurons in D2R-KO mice displayed place-related activity. These results provide evidence that D2R in the NAc participates in coding for a specific type of neural response to incentive contingencies and partly in spatial learning.
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Genetic deletion or pharmacologic blockade of D2 receptors impairs operant responding, particularly the willingness to work for a reward.
“Genetic deletion (Tran et al., 2002) or pharmacologic blockade (Salamone et al., 2007) of D2 receptors impair operant responding, in particular the willingness to work for a reward.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Tran et al., 2002
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- Authors
- Tran, A. H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., & Ono, T.
- Affiliations
- National Institute for Basic Biology (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-06-25
- Volume
- 99
- Issue
- 13
- Pages
- 8986-8991
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC124410
- OpenAlex
- W2108031320
- Cited by
- 67
- References
- 38
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine D2 receptor, nucleus accumbens, reward prediction, place learning, spatial learning, locomotor activity, associative learning
- MeSH terms
- Animals, Behavior, Animal, Male, Nucleus Accumbens, Reward, Receptors, Dopamine D2, Mice, Knockout, Mice
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