A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foraging

Floresco, Stan B.; Seamans, Jeremy K.; Phillips, Anthony G.

doi:10.1016/0166-4328(96)00031-9

Cited by 58Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsNeural and Behavioral Psychology Studies

A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foraging

Floresco, Stan B., Seamans, Jeremy K., Phillips, Anthony G.·1996·Behavioural Brain Research

DOI 10.1016/0166-4328(96)00031-9

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Abstract

The role of mesoaccumbens dopamine (DA) in radial-arm maze foraging is assessed by infusing low doses of the DA antagonist haloperidol into the nucleus accumbens (N.Acc.). Infusions of haloperidol (0, 125, 250 or 500 ng/0.5 microliter) into the N.Acc. of well-trained rats dose-dependently increase the number of re-entries to arms (errors) during the random foraging task, in which 4 arms on an 8-arm maze are baited randomly. However, in a separate group of animals, similar infusions produce no impairment when delivered prior to the test phase of the delayed spatial win-shift task, which require the animal to acquire information during a training phase, and to use that information 30 min later, during a test phase. These results suggest that DA neurotransmission in the N.Acc. is crucial for foraging behavior when there is ambiguity about the location of reward in a spatial environment, but is not needed for efficient foraging behavior when an animal has previous information as to the location of rewarding stimuli. The results are discussed with respect to of the underlying physiological interactions between limbic glutamate and mesoaccumbens DA transmission in the N.Acc.

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If rats can use information that they learned prior to receiving intra-accumbens haloperidol, no impairment is found in collecting bait from the eight arm maze.
“On the other hand, if rats can use information that they learned prior to receiving intra-accumbens haloperidol, no impairment is found in collecting bait from the eight arm maze (Floresco et al., 1996).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Floresco et al., 1996
Dopamine receptor blockade in the nucleus accumbens disrupts a random foraging task: haloperidol-treated rats increase re-entries (errors) in an eight arm maze as they collect bait from four randomly baited arms.
“Also, dopamine receptor blockade in the accumbens disrupts a random foraging task: haloperidol-treated rats increase re-entries (errors) in an eight arm maze as they collect bait from four randomly baited arms.”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Floresco et al., 1996

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Authors: Floresco, S. B., Seamans, J. K., & Phillips, A. G.
Affiliations: University of British Columbia (CA)
Corresponding author: Phillips, Anthony G.
ORCID: Floresco, Stan B.
Seamans, Jeremy K.
Phillips, Anthony G.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 1996-10
Volume: 80
Issue: 1-2
Pages: 161-168
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/0166-4328(96)00031-9
OpenAlex: W1984003649
Cited by: 56
References: 55
Citations by year: 2023: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
FWCI: 1.35
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: dopamine, nucleus accumbens, haloperidol, radial maze, foraging behavior
MeSH terms: Animals, Dopamine, Dose-Response Relationship, Drug, Feeding Behavior, Haloperidol, Male, Nucleus Accumbens, Space Perception, Receptors, Dopamine D1, Dopamine Antagonists, Glutamic Acid, Rats, Dopamine D2 Receptor Antagonists

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A selective role for dopamine in the nucleus accumbens of the rat in random foraging but not delayed spatial win-shift-based foraging

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