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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
Open accessAbstract
siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/kg), rats (ED50 < 0.01 mg/kg), and nonhuman primates (over 95% silencing at 0.3 mg/kg). Apolipoprotein E plays a significant role in the potency of cKK-E12 both in vitro and in vivo. cKK-E12 was highly selective toward liver parenchymal cell in vivo, with orders of magnitude lower doses needed to silence in hepatocytes compared with endothelial cells and immune cells in different organs. Toxicity studies showed that cKK-E12 was well tolerated in rats at a dose of 1 mg/kg (over 100-fold higher than the ED50). To our knowledge, this is the most efficacious and selective nonviral siRNA delivery system for gene silencing in hepatocytes reported to date.
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“The delivery of therapeutic RNA molecules (siRNA or microRNA) encapsulated within the lipid or lipid-like carrier231,232 into the cells or tissues was proven to be effective in infectious diseases and tumors, as shown in many preclinical studies233,234,235 and clinical trials (reviewed by Kaczmarek et al.236).”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [233]
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“Some other LNPs were reported with organ specificity, such as cKK-E12 lipopeptide nanoparticles, wherein the lipid tails were conjugated to peptide derivatives and achieved liver targeting siRNA delivery.[67]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [67]
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
Self-citationRational design of cationic lipids for siRNA delivery
Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822 · cited 1×
“TTR, primarily synthesized in hepatocytes, plays significant roles in transporting thyroxine and retinol (10).”
BackgroundSelf-citationAbdel‐Magid, A. F., Carson, K. G., Harris, B. D., Maryanoff, C. A., & Shah, R. D. (1996) · The Journal of Organic Chemistry · doi:10.1021/jo960057x · Cited by 1,521
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., Jayaraman, M., Rajeev, K. G., Cantley, W. L., Dorkin, J. R., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.85 · Cited by 1,261
Self-citationBio-inspired, bioengineered and biomimetic drug delivery carriers
Yoo, J., Irvine, D. J., Discher, D. E., & Mitragotri, S. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3499 · Cited by 1,251
The promises and pitfalls of RNA-interference-based therapeutics
Castanotto, D., & Rossi, J. J. (2009) · Nature · doi:10.1038/nature07758 · Cited by 1,241
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akinc, A., Zumbuehl, A., Goldberg, M., Leshchiner, E. S., Busini, V., Hossain, N., Bacallado, S. A., Nguyen, D. N., Fuller, J., Alvarez, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1402 · Cited by 1,150
Self-citationGenetic Heterogeneity in Human Disease
McClellan, J., & King, M.-C. (2010) · Cell · doi:10.1016/j.cell.2010.03.032 · Cited by 981
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Aravalli, R. N., & Steer, C. J. (2016) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1158808 · Cited by 22
Recent Developments in Delivery of MicroRNAs Utilizing Nanosystems for Metabolic Syndrome Therapy
Li, T., Zhu, L., Zhu, L., Wang, P., Xu, W., & Huang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157855 · Cited by 23
Das, R., Ge, X., Fei, F., Parvanian, S., Weissleder, R., & Garris, C. (2024) · Small Methods · doi:10.1002/smtd.202400633 · Cited by 22
Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy
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Lipid‐based nucleic acid therapeutics with in vivo efficacy
Sufian, M. A., & Ilies, M. A. (2022) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1856 · Cited by 23
Porosk, L., Härk, H. H., Arukuusk, P., Haljasorg, U., Peterson, P., & Kurrikoff, K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030952 · Cited by 22
The clinical progress and challenges of mRNA vaccines
Yu, M., Wang, N., Zhu, J., & Lin, Y. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1894 · Cited by 23
The Potential of Nanomedicine to Unlock the Limitless Applications of mRNA
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Shi, Q., Song, C., Chen, M., Xu, J., Zheng, S., Tan, J., Zhang, J., Wang, N., Hu, J., & Liu, S. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c07577 · Cited by 20
Li, J., Hu, J., Jin, D., Huo, H., Chen, N., Lin, J., & Lu, X. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02919-1 · Cited by 24
Engineered microRNA therapeutics
Gibson, N. (2014) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.4997/jrcpe.2014.302 · Cited by 20
Cérda, S. L., Fontana, F., Wang, S., Correia, A., Molinaro, G., Tello, R. P., Hirvonen, J. J., Celia, C., Barreto, G., & Santos, H. A. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300048 · Cited by 19
Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets
Khare, P., Edgecomb, S. X., Hamadani, C. M., Conway, J. F., Tanner, E. E. L., & Manickam, D. S. (2023) · Nanoscale Advances · doi:10.1039/d3na00699a · Cited by 21
Preparation and Optimization of Lipid-Like Nanoparticles for mRNA Delivery
Li, B., & Dong, Y. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7138-1_13 · Cited by 20
Self-citationNon-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
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Huayamares, S. G., Lian, L., Rab, R., Hou, Y., Radmand, A., Kim, H., Zenhausern, R., Achyut, B. R., Gilbert‐Ross, M., Lokugamage, M. P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58548-1 · Cited by 17
Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs
Fenton, O. S., Kauffman, K. J., McClellan, R. L., Kaczmarek, J. C., Zeng, M. D., Andresen, J. L., Rhym, L. H., Heartlein, M. W., DeRosa, F., & Anderson, D. G. (2018) · Angewandte Chemie · doi:10.1002/ange.201809056 · Cited by 18
Self-citationKritika, Pant, M., Yadav, M., Verma, A. K., Mahapatro, A. K., & Roy, I. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02447k · Cited by 18
Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo
Luo, X., Wang, W., Dorkin, J. R., Omid Veiseh, A., Chang, P., Ionita, I. A., Danino, D., Langer, R., Anderson, D. G., & Dong, Y. (2016) · Biomaterials Science · doi:10.1039/c6bm00683c · Cited by 18
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Conde, J., Shomron, N., & Artzi, N. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600414 · Cited by 18
Sun, Q., Zhang, H., Ding, F., Gao, X., Zhu, Z., & Yang, C. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.123845 · Cited by 18
Smekalova, E. M., Gerashchenko, M. V., O’Connor, P. B. F., Whittaker, C. A., Kauffman, K. J., Fefilova, A. S., Zatsepin, T. S., Bogorad, R. L., Baranov, P. V., Langer, R., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.11.009 · Cited by 17
Self-citationLin, P. J. C., & Tam, Y. K. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.108 · Cited by 18
Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery
Li, Y., Chakraborty, A., Chen, J., & Xu, Q. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00445 · Cited by 17
An FGFR1-Binding Peptide Modified Liposome for siRNA Delivery in Lung Cancer
Dong, Z., Yin, Y., Luo, J., Li, B., Lou, F., Wang, Q., Zhou, Q., Ye, B., & Wang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158380 · Cited by 16
Anderson, C. F., Singh, A. N., Stephens, T., Hoang, C. D., & Schneider, J. P. (2024) · Advanced Materials · doi:10.1002/adma.202314367 · Cited by 16
Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery
He, Z., Liu, Z., & Chen, Y. (2024) · ChemMedChem · doi:10.1002/cmdc.202400199 · Cited by 16
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Messenger RNA as a Novel Therapeutic Approach
Stanton, M. G., & Murphy-Benenato, K. E. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2016_30 · Cited by 16
Switchable Lipids: Conformational Change for Fast pH‐Triggered Cytoplasmic Delivery
Viricel, W., Mbarek, A., & Chain, J. L. (2015) · Angewandte Chemie · doi:10.1002/ange.201504661 · Cited by 17
RNA interference-based technology: what role in animal agriculture?
Bradford, B. J., Cooper, C. A., Tizard, M. L., Doran, T. J., & Hinton, T. M. (2016) · Animal Production Science · doi:10.1071/an15437 · Cited by 17
Lipid nanoparticles: A delicate nucleic acid delivery system to be further explored
Ma, R., Li, Y., Su, Y., Chen, P., Xie, S., Tan, W., & Liu, X. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102586 · Cited by 15
Stone, D., Takeuchi, R., Dulin, H., Loprieno, M. A., Strongin, D. E., Sathees, S., Cradick, T. J., Aubert, M., Roychoudhury, P., Gordon, J., et al. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101470 · Cited by 15
Guo, K., Bu, L., Du, J., Zhang, W., Xia, J., Tao, M., Shao, X., Liu, L.-J., Zhao, W., Cai, Y., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114126 · Cited by 19
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Gentry, K., Lian, L., Kim, H., Celik, O., Jones, C., Podilapu, A. R., Shakked, A., Loughrey, D., Zenhausern, R., Jang, B., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409569122 · Cited by 17
Hamilton, A. G., Thatte, A. S., Xu, J., Luo, Z., Safford, H. C., Swingle, K. L., Muscat-Rivera, J., Kegel, M., Han, X., Joseph, R. A., et al. (2026) · Advanced Materials · doi:10.1002/adma.202514370 · Cited by 19
Whang, C., Hong, J., Kim, D., Ryu, H., Jung, W., Son, Y., Keum, H., Kim, J., Shin, H., Moon, E., et al. (2022) · Advanced Materials · doi:10.1002/adma.202203993 · Cited by 15
Huang, C., Zhang, Y., Su, J., Guan, X., Chen, S., Xu, X., Deng, X., Zhang, L., & Huang, J. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s434908 · Cited by 15
Self-citationAhmed, T. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16336 · Cited by 18
Localization of Intramuscular mRNA Delivery Using Deep Eutectic‐Lipid Nanocomposites
Curreri, A. M., Dunne, M., Bibbey, M. G., Kapate, N., Kim, J., & Mitragotri, S. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400327 · Cited by 15
Current views on inducing synthetic lethal RNAi responses in the treatment of cancer
Kacsinta, A. D., & Dowdy, S. F. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2016.1110141 · Cited by 15
Lorents, A., Maloverjan, M., Padari, K., & Pooga, M. (2021) · Pharmaceuticals · doi:10.3390/ph14070667 · Cited by 14
AMD Genomics: Non-Coding RNAs as Biomarkers and Therapeutic Targets
Zhang, C., Owen, L. A., Lillvis, J. H., Zhang, S. X., Kim, I. K., & DeAngelis, M. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061484 · Cited by 19
Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for siRNA Delivery
Eldredge, A. C., Johnson, M. E., Oldenhuis, N. J., & Guan, Z. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00635 · Cited by 15
MiR-128-3p – a gray eminence of the human central nervous system
Kiel, K., Król, S. K., Bronisz, A., & Godlewski, J. (2024) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2024.102141 · Cited by 15
The future of genetic medicines delivered via targeted lipid nanoparticles to leukocytes
Tarab‐Ravski, D., Stotsky‐Oterin, L., Elisha, A., Kundoor, G. R., Ramishetti, S., Hazan‐Halevy, I., Haas, H., & Peer, D. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.014 · Cited by 13
Danz, H., Dauner, A. L., Sharma, S., Babiceanu, M., Clark, N., Ontiveros, R. J., Amezquita, R. A., Zhilin-Roth, A., Reyes, E., Khoo, C., et al. (2025) · npj Vaccines · doi:10.1038/s41541-025-01263-1 · Cited by 15
Self-citationMeerasa, S. S., Ahmad, A., Khan, A. A., Haque, S., & Saleem, I. Y. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126263 · Cited by 14
Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines
Rudra, A., Gupta, A., Reed, K., Deik, A., Min, J., Mansour, H. M. A., Nguyen, Q. T. C., Danko, A., Hu, Y., Berger, A., et al. (2025) · Nature Nanotechnology · doi:10.1038/s41565-025-02044-6 · Cited by 18
Self-citationAdvances in the development of lipid nanoparticles for ophthalmic therapeutics
Chen, S., Deng, Z., & Ji, D. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117108 · Cited by 16
Khan, O. F., Zaia, E. W., Yin, H., Bogorad, R. L., Pelet, J. M., Webber, M. J., Zhuang, I., Dahlman, J. E., Langer, R., & Anderson, D. G. (2014) · Angewandte Chemie · doi:10.1002/ange.201408221 · Cited by 14
Self-citationA multi-scale molecular dynamics simulation of PMAL facilitated delivery of siRNA
Li, J., Ouyang, Y., Kong, X., Zhu, J., Lu, D., & Liu, Z. (2015) · RSC Advances · doi:10.1039/c5ra10965e · Cited by 14
Factors Influencing the Delivery Efficiency of Cancer Nanomedicines
Ullah, R., Wazir, J., Khan, F. U., Diallo, M. T., Ihsan, A. U., Mikrani, R., Aquib, M., & Zhou, X. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01691-3 · Cited by 15
Nucleic acid delivery by ionizable nanocarriers for brain disease treatment
Xiong, R., Ling, G., Zhang, Y., Guan, J., & Zhang, P. (2023) · Brain‐X · doi:10.1002/brx2.7 · Cited by 13
Self-citationSelf-assembled aggregates based on cationic amphiphilic peptides: structural insight
Rosa, E., Diaferia, C., de Mello, L. R., Seitsonen, J. J. T., Hamley, I. W., & Accardo, A. (2023) · Soft Matter · doi:10.1039/d3sm00363a · Cited by 14
Wang, S., Guo, B., Wang, H., & Yang, F. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105547 · Cited by 14
Preclinical Advances in LNP-CRISPR Therapeutics for Solid Tumor Treatment
Wang, S., Zhu, Y., Du, S., & Zheng, Y. (2024) · Cells · doi:10.3390/cells13070568 · Cited by 16
Multiple tail ionizable lipids improve in vivo mRNA delivery efficiency with biosafety
Liu, C., Jiang, Y., Xue, W., Liu, J., Wang, Z., & Li, X. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124868 · Cited by 14
Non-viral nucleic acid therapeutics: Revolutionizing the landscape of atherosclerotic treatment
Qu, S., Liu, R., Zhang, N., Xu, Y., Yue, X., & Dai, Z. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101514 · Cited by 14
Advances in mRNA‐Lipid Nanoparticle Engineering for Immune Cell Targeting and Immune Modulation
Kim, C., Lee, Y., Lee, H., & Kim, B. (2025) · Small Methods · doi:10.1002/smtd.202501401 · Cited by 13
High-throughput, AI-assisted design and optimization of lipid nanoparticles for drug delivery
Zeng, J., Chen, R., He, S., Zhang, C., Liu, W.-C., Song, H., Liu, S., & Nan, K. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114573 · Cited by 15
Enzyme Induced Formation of Monodisperse Hydrogel Nanoparticles Tunable in Size
Bocharova, V., Sharp, D., Jones, A., Cheng, S., Griffin, P. J., Agapov, A. L., Voylov, D. N., Wang, Y., Kisliuk, A. M., Melman, A., et al. (2015) · Chemistry of Materials · doi:10.1021/acs.chemmater.5b00187 · Cited by 13
Solving Donor Organ Shortage with Insights from Freeze Tolerance in Nature
Luu, B. E., & Storey, K. B. (2018) · BioEssays · doi:10.1002/bies.201800092 · Cited by 12
Research progress of mRNA vaccines for infectious diseases
Zhang, Z., Du, J., Zhang, D., Han, R., Wu, X., & Liang, Y. (2025) · European journal of medical research · doi:10.1186/s40001-025-03060-x · Cited by 19
Man, Y., Posey, R. R., Bai, H., Jiang, A. R., Dosta, P., Ocampo-Alvarado, D., Plebani, R., Ji, J., Belgur, C., Artzi, N., et al. (2025) · Lab on a Chip · doi:10.1039/d5lc00156k · Cited by 11
Shaharyar, M. A., Bhowmik, R., Al-Abbasi, F. A., AlGhamdi, S. A., Alghamdi, A. M., Sarkar, A., Kazmi, I. A., & Karmakar, S. (2023) · Vaccines · doi:10.3390/vaccines11020241 · Cited by 12
Amphiphilic dynamic covalent polymer vectors of siRNA
Coll, J. G., Trousselier, P., Pawar, S. D., Bessin, Y., Lichon, L., Chain, J. L., Sachon, E., Bettache, N., & Ulrich, S. (2024) · Chemical Science · doi:10.1039/d4sc07668k · Cited by 11
Lipid Nanoparticles for mRNA Delivery in Cancer Immunotherapy
Alshehry, Y., Liu, X., Li, W., Wang, Q., Cole, J., & Zhu, G. (2025) · The AAPS Journal · doi:10.1208/s12248-025-01051-8 · Cited by 13
Lipid Nanoparticle: Beyond Delivery Vehicle—Unveiling Its Immunological Adjuvant Potential
Amor, N. P., Guo, K., Zhang, S., Xia, J., Yang, Y., & Lin, A. (2025) · The FASEB Journal · doi:10.1096/fj.202500622r · Cited by 12
Lau, Y. M. A., Pang, J., Tilstra, G., Couture‐Senécal, J., & Khan, O. F. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2144827 · Cited by 11
Applications and challenges of biomaterial mediated mRNA delivery
Fang, H., & Chen, Q. (2022) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2022.00093 · Cited by 12
Design and development of effective siRNA delivery vehicles
Putnam, D. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401746111 · Cited by 10
RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver
Yin, H., Bogorad, R. L., Barnes, C., Walsh, S. C., Zhuang, I., Nonaka, H., Ruda, V. M., Kuchimanchi, S., Nechev, L. V., Akinc, A., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.028 · Cited by 10
Self-citationDelivery strategies: RNA interference in agriculture and human health
Heidebrecht, R. W. (2016) · Pest Management Science · doi:10.1002/ps.4341 · Cited by 10
Cérda, S. L., Molinaro, G., Tello, R. P., Correia, A., Waris, E., Hirvonen, J. J., Barreto, G., & Santos, H. A. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c02996 · Cited by 9
Application of PPAR Ligands and Nanoparticle Technology in Metabolic Steatohepatitis Treatment
Vu, H. T., Nguyen, V. D., Ikenaga, H., & Matsubara, T. (2024) · Biomedicines · doi:10.3390/biomedicines12081876 · Cited by 9
siRNA as potential therapeutic strategy for hypertension
Tanna, S., Doshi, G., & Godad, A. P. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176467 · Cited by 9
Chimeric peptide-mediated siRNA transduction to inhibit HIV-1 infection
Bivalkar-Mehla, S., Mehla, R., & Chauhan, A. (2016) · Journal of drug targeting · doi:10.1080/1061186x.2016.1245311 · Cited by 9
Delivering CRISPR to the HIV-1 reservoirs
Gurrola, T. E., Effah, S. N., Sariyer, I. K., Dampier, W., Nonnemacher, M. R., & Wigdahl, B. L. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1393974 · Cited by 11
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Alqahtani, M. S., Syed, R., Alqahtani, A. S., Almarfadi, O. M., Roni, M. A., & Sadhu, S. S. (2024) · Nanoscale Advances · doi:10.1039/d4na00404c · Cited by 8
Nanoparticle-mediated delivery of siRNA: Targeting gene silencing in cancer therapy
Udappusamy, V., Thangam, S. N., Ramasamy, N. K., Ganeshan, S., Rajan, D. K., & Moovendhan, M. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106973 · Cited by 9
Guzman, E. B., Kowalski, P. S., Langer, R., & Anderson, D. G. (2025) · Science Advances · doi:10.1126/sciadv.ady2738 · Cited by 8
Self-citationmRNA-LNP vaccines: rational design, delivery optimization, and clinical translation
Jiang, S., & Lu, Z. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01972a · Cited by 10
Gong, F., Xu, Y., Chen, J., Zhang, S., Dong, S., Healy, L., Seto, B. Y., Zhou, M., Lu, R. X. Z., Li, G., et al. (2026) · Nature Materials · doi:10.1038/s41563-026-02555-0 · Cited by 8
Self-citationBassit, A. C. F. (2015) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000257 · Cited by 8
Jang, B., Jang, H.-J., Kim, H., Kim, M., Jeong, M., Lee, G. S., Lee, K., & Lee, H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.009 · Cited by 7
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Kimura, S., & Harashima, H. (2024) · BioDrugs · doi:10.1007/s40259-024-00647-4 · Cited by 8
Kolhatkar, V., Khambati, H., Lote, A. R., Shanine, P., Insley, T., Sen, S., Munirathinam, G., Král, P., & Kolhatkar, R. B. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1455-7 · Cited by 7
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Jin, S., & Sung, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147612 · Cited by 9
Mo, Y., Liu, H., Keszei, A. F. A., Dai, D. L., Makky, A., Ding, L., Pan, A., Bu, J., Mazhab‐Jafari, M. T., Chen, J., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c16025 · Cited by 6
Pawar, S., Pingale, P., Garkal, A., Osmani, R. A. M., Gajbhiye, K. R., Kulkarni, M., Pardeshi, K., Mehta, T. A., & Rajput, A. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131139 · Cited by 6
Beckert, N., Dietrich, A., & Hubbuch, J. J. (2024) · Pharmaceuticals · doi:10.3390/ph17091217 · Cited by 6
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Su, L.-J., Ji, Z.-H., Xu, M.-X., Zhu, J.-Q., Chen, Y., Qiao, J.-F., Wang, Y., & Lin, Y. (2023) · Nano Research · doi:10.1007/s12274-023-6238-5 · Cited by 7
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Shiekh, F. A., Farooq, O., Mian, S. H., Bautista, R. L., Arja, S. B., & Andrabi, K. I. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0043 · Cited by 6
Metadata
- Authors
- Dong, Y., Love, K. T., Dorkin, J. R., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R. L., Yin, H., Chen, Y., Vegas, A. J., Alabi, C. A., Sahay, G., Olejnik, K. T., Wang, W., Schroeder, A., Lytton-Jean, A. K. R., Siegwart, D. J., Akinc, A., Barnes, C., Barros, S. A., Carioto, M., Fitzgerald, K., Hettinger, J., Kumar, V., Novobrantseva, T. I., Qin, J., Querbes, W., Koteliansky, V., Langer, R., & Anderson, D. G.
- Affiliations
- Boston Children's Hospital (US)
- Massachusetts Institute of Technology (US)
- Koch Institute for Integrative Cancer Research At MIT (US)
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;
- Alnylam Pharmaceuticals (United States) (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-02-10
- Volume
- 111
- Issue
- 11
- Pages
- 3955-3960
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3964096
- OpenAlex
- W2071030419
- Cited by
- 488
- References
- 35
- Citations by year
- 2026: 29 · 2025: 45 · 2024: 53 · 2023: 51 · 2022: 40 · 2021: 42 · 2020: 35 · 2019: 30 · 2018: 29 · 2017: 39 · 2016: 41 · 2015: 36 · 2014: 17
- FWCI
- 18.19
- Type
- journal article
- Language
- en
- Update notices
- correction (2014-03-26)
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- Alnylam Pharmaceuticals
- National Institutes of Health (5r01de016516-10, 4r37eb000244-34, 5-R01-, 1f32eb017625-01, 5r01ca132091-04, CA151884, DE-016516, U54-CA151884, EB-000244, R01-EB000244-27, DE016516-03)
- National Heart, Lung, and Blood Institute (HHSN268201000045C)
- National Cancer Institute (5-R01-CA132091–04, U54CA151884, CA151884, R01-CA132091)
- National Institute of Biomedical Imaging and Bioengineering (R01-EB000244-27, EB-000244, R01EB000244, R37-EB000244, 1F32EB017625, F32 EB017625)
- National Institute of Dental and Craniofacial Research (R01DE016516-03)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- siRNA delivery, apolipoprotein E, hepatocyte targeting, liver parenchymal cells, siRNA therapeutics, toxicity, rodents, non-human primates, lipoproteins
- MeSH terms
- Animals, Apolipoproteins E, Macaca fascicularis, Drug Delivery Systems, Cryoelectron Microscopy, Gene Silencing, Hepatocytes, RNA, Small Interfering, Mice, Rats, Nanoparticles, Lipopeptides
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