Cited by 679Autophagy in Disease and TherapyMitochondrial Function and PathologyCellular transport and secretion

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Transcellular degradation of axonal mitochondria

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Davis, Chung-ha O., Kim, Keun-Young, Bushong, Eric A., Mills, Elizabeth A., Boassa, Daniela, Shih, Tiffany, Kinebuchi, Mira, Phan, Sebastien, Zhou, Yi, Bihlmeyer, Nathan A., Nguyen, Judy V., Jin, Yunju, Ellisman, Mark H., Marsh-Armstrong, Nicholas·2014·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1404651111PMC PMC4084443

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Abstract

Significance: Mitochondria are organelles that perform many essential functions, including providing the energy to cells. Cells remove damaged mitochondria through a process called mitophagy. Mitophagy is considered a subset of a process called autophagy, by which damaged organelles are enwrapped and delivered to lysosomes for degradation. Implicit in the categorization of mitophagy as a subset of autophagy, which means “self-eating,” is the assumption that a cell degrades its own mitochondria. However, we show here that in a location called the optic nerve head, large numbers of mitochondria are shed from neurons to be degraded by the lysosomes of adjoining glial cells. This finding calls into question the assumption that a cell necessarily degrades its own organelles.

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Authors: Davis, C.-H. O., Kim, K.-Y., Bushong, E. A., Mills, E. A., Boassa, D., Shih, T., Kinebuchi, M., Phan, S., Zhou, Y., Bihlmeyer, N. A., Nguyen, J. V., Jin, Y., Ellisman, M. H., & Marsh-Armstrong, N.
Affiliations: Kennedy Krieger Institute (US)
University of California San Diego (US)
National Center for Microscopy and Imaging Research, Center for Research in Biological Systems, Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093
Johns Hopkins University (US)
The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;
ORCID: Davis, Chung-ha O.
Bushong, Eric A.
Mills, Elizabeth A.
Boassa, Daniela
Zhou, Yi
Bihlmeyer, Nathan A.
Ellisman, Mark H.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2014-06-16
Volume: 111
Issue: 26
Pages: 9633-9638
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1404651111
PMC: PMC4084443
OpenAlex: W2025060864
Cited by: 673
References: 29
Citations by year: 2026: 48 · 2025: 72 · 2024: 66 · 2023: 84 · 2022: 65 · 2021: 72 · 2020: 61 · 2019: 48 · 2018: 38 · 2017: 52 · 2016: 30 · 2015: 28 · 2014: 8
FWCI: 29.80
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Science Foundation (DGE-1,232,825, 1232825)
Glaucoma Research Foundation
Barr Foundation
National Institutes of Health (5r01ey022680-02)
National Institute on Drug Abuse (R01DA016602, DA016602)
National Eye Institute (R01 EY022680, R01EY019960)
National Institute of General Medical Sciences (R01GM082949, P41GM103412, T32GM007814, 5-T32-GM07814, 5R01GM82949)
National Institute of Neurological Disorders and Stroke (P30NS050274)
National Center for Research Resources (P41RR004050, DA016602)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: mitochondrial degradation, retinal ganglion cell axons, optic nerve head, astrocytes, axonal mitochondria, lysosomes, neuronal mitochondria
MeSH terms: Red Fluorescent Protein, Animals, Astrocytes, Axons, Exocytosis, Immunohistochemistry, Luminescent Proteins, Lysosomes, Optic Disk, Phagocytosis, Retinal Ganglion Cells, In Situ Hybridization, Fluorescence, In Situ Nick-End Labeling, Imaging, Three-Dimensional, Mice, Electron Microscope Tomography, Mitophagy

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