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The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging

Lavarti, Rupa, Alvarez-Diaz, Tatiana, Marti, Kyarangelie, Kar, Parmita, Raju, Raghavan Pillai·2025·Ageing Research Reviews
DOI 10.1016/j.arr.2025.102760PMC PMC12145239
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  • Transient, targeted interventions may be safer and more effective than permanent, systemic elimination of senescent cells.

    “This duality highlights that transient, targeted interventions may be safer and more effective than permanent, systemic elimination of SnCs136.”

    From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [136]

    The wound-healing section (page unavailable) says transient senescence helps tissue repair, while the therapeutic section describes intermittent treatment and targeted approaches, including one with less platelet toxicity. These passages support the rationale for selective intervention, but the paper does not establish that transient, targeted interventions are generally safer and more effective than permanent, systemic elimination of senescent cells. (LLM, conf=0.84)

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Metadata

Authors
Lavarti, R., Alvarez-Diaz, T., Marti, K., Kar, P., & Raju, R. P.
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2025-07
Volume
109
Pages
102760
ISSN
1568-1637
DOI
10.1016/j.arr.2025.102760
PMC
PMC12145239
Cited by
21
References
120
Language
en
Licence
Funders
  • National Institute on Aging
  • NIH National Institute of General Medical Sciences
  • Augusta University
  • National Institutes of Health (I01BX006256)
  • US Department of Veterans Affairs

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