Metabolic resting-state brain networks in health and disease
Open accessAbstract
The delineation of resting state networks (RSNs) in the human brain relies on the analysis of temporal fluctuations in functional MRI signal, representing a small fraction of total neuronal activity. Here, we used metabolic PET, which maps nonfluctuating signals related to total activity, to identify and validate reproducible RSN topographies in healthy and disease populations. In healthy subjects, the dominant (first component) metabolic RSN was topographically similar to the default mode network (DMN). In contrast, in Parkinson's disease (PD), this RSN was subordinated to an independent disease-related pattern. Network functionality was assessed by quantifying metabolic RSN expression in cerebral blood flow PET scans acquired at rest and during task performance. Consistent task-related deactivation of the "DMN-like" dominant metabolic RSN was observed in healthy subjects and early PD patients; in contrast, the subordinate RSNs were activated during task performance. Network deactivation was reduced in advanced PD; this abnormality was partially corrected by dopaminergic therapy. Time-course comparisons of DMN loss in longitudinal resting metabolic scans from PD and Alzheimer's disease subjects illustrated that significant reductions appeared later for PD, in parallel with the development of cognitive dysfunction. In contrast, in Alzheimer's disease significant reductions in network expression were already present at diagnosis, progressing over time. Metabolic imaging can directly provide useful information regarding the resting organization of the brain in health and disease.
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Aerobic glycolysis and lactate might reflect cortical information processing and, in turn, intracortical communication.
“In particular, aerobic glycolysis and lactate might reflect cortical information processing and, in turn, intracortical communication”
From Perception is associated with the brain’s metabolic response to sensory stimulation (2022) · cites this paper as Spetsieris et al., 2015
The introductory passage says that resting glucose consumption supports synaptic activity, and the Discussion says metabolic imaging may reflect resting neural activity. Neither passage addresses whether aerobic glycolysis or lactate reflects cortical information processing or intracortical communication. Searches for those terms found only a reference to a paper on aerobic glycolysis, not a discussion of the claimed relationship. (LLM, conf=0.74)
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Cited by
Sorted by citations
Perception is associated with the brain’s metabolic response to sensory stimulation
DiNuzzo, M., Mangia, S., Moraschi, M., Mascali, D., Hagberg, G. E., & Giove, F. (2022) · eLife · doi:10.7554/elife.71016 · Cited by 25 · see citing works
“In particular, aerobic glycolysis and lactate might reflect cortical information processing and, in turn, intracortical communication, in agreement with the relation between regional metabolic rates of glucose utilization and resting- state network dynamics in the cerebral cortex (Jamadar et al., 2020; Noack et al., 2…”
Background
- Authors
- Spetsieris, P. G., Ko, J. H., Tang, C. C., Nazem, A., Sako, W., Peng, S., Ma, Y., Dhawan, V., & Eidelberg, D.
- Affiliations
- Feinstein Institute for Medical Research (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-02-09
- Volume
- 112
- Issue
- 8
- Pages
- 2563-2568
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4345616
- OpenAlex
- W2015203806
- Cited by
- 100
- References
- 44
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 15 · 2017: 12 · 2016: 13 · 2015: 2
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Neurological Disorders and Stroke (P50 NS071675)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- resting-state brain networks, resting metabolic rate, default mode network, Parkinson's disease, Alzheimer's disease, cerebral blood flow, dopaminergic therapy, cognitive impairment
- MeSH terms
- Alzheimer Disease, Brain, Brain Mapping, Disease, Female, Health, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motor Activity, Nerve Net, Parkinson Disease, Rest, Task Performance and Analysis, Principal Component Analysis, Positron-Emission Tomography
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