Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease
Open accessAbstract
Alzheimer's disease (AD) is a neurodegenerative disorder that prominently affects cerebral connectivity. Assessing the functional connectivity at rest, recent functional MRI (fMRI) studies reported on the existence of resting-state networks (RSNs). RSNs are characterized by spatially coherent, spontaneous fluctuations in the blood oxygen level-dependent signal and are made up of regional patterns commonly involved in functions such as sensory, attention, or default mode processing. In AD, the default mode network (DMN) is affected by reduced functional connectivity and atrophy. In this work, we analyzed functional and structural MRI data from healthy elderly (n = 16) and patients with amnestic mild cognitive impairment (aMCI) (n = 24), a syndrome of high risk for developing AD. Two questions were addressed: (i) Are any RSNs altered in aMCI? (ii) Do changes in functional connectivity relate to possible structural changes? Independent component analysis of resting-state fMRI data identified eight spatially consistent RSNs. Only selected areas of the DMN and the executive attention network demonstrated reduced network-related activity in the patient group. Voxel-based morphometry revealed atrophy in both medial temporal lobes (MTL) of the patients. The functional connectivity between both hippocampi in the MTLs and the posterior cingulate of the DMN was present in healthy controls but absent in patients. We conclude that in individuals at risk for AD, a specific subset of RSNs is altered, likely representing effects of ongoing early neurodegeneration. We interpret our finding as a proof of principle, demonstrating that functional brain disorders can be characterized by functional-disconnectivity profiles of RSNs.
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The default mode network shows reduced connectivity in early-stage Alzheimer's disease.
“a functional network showing reduced connectivity in early-stage Alzheimer’s disease (Sorg et al., 2007; Chhatwal et al., 2013)”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Sorg et al., 2007
The Abstract says the default mode network has reduced functional connectivity in AD, and the Results report diminished connectivity in patients with amnestic mild cognitive impairment. The study’s patients were at high risk for AD, however, rather than diagnosed with early-stage AD; its direct finding does not establish the claim for that population. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThe dynamics of functional connectivity alteration, both spatial and temporal, differ from patterns observed in Alzheimer's disease patients.
“The dynamics of alteration, both spatial and temporal, differ from patterns observed in AD patients, which is marked with early altered FC in the default mode network and aggravated FC in the transition from mild cognitive impairments to AD (Greicius et al., 2004;Rombouts et al., 2005;Sorg et al., 2007;Sheline et al., 2010a,b).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Sorg et al., 2007
The Abstract and Results report reduced default-mode-network functional connectivity in people with amnestic MCI, supporting the claim of early alteration. The study compares these patients with healthy controls, not with AD patients over time; the Results say a two-year follow-up was still underway. It therefore does not establish distinct spatial and temporal dynamics or worsening connectivity during the transition from MCI to AD. Page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredDefault mode network connectivity was reported affected in subjects at risk of developing Alzheimer's disease, including patients with mild cognitive impairment, cognitively healthy elders with amyloid deposits, and midlife carriers of the APOE4 risk allele.
“Additionally, DMN connectivity was reported affected in subjects at risk of developing AD including patients with mild cognitive impairment (Rombouts et al., 2005;Sorg et al., 2007), in cognitively healthy elders with amyloid deposits (Hedden et al., 2009;Sperling et al., 2009;Sheline et al., 2010b), and in midlife carriers of APO 4 risk allele (Sheline et al., 2010a;Canuet et al., 2012).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Sorg et al., 2007
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Control of goal-directed and stimulus-driven attention in the brain
Corbetta, M., & Shulman, G. L. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn755 · Cited by 12,881 · see citing works
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812 · see citing works
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700 · see citing works
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576 · see citing works
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works
Consistent resting-state networks across healthy subjects
Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., & Beckmann, C. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601417103 · Cited by 4,326 · see citing works
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130 · see citing works
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684 · see citing works
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371 · see citing works
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works
A method for making group inferences from functional MRI data using independent component analysis
Calhoun, V. D., Adali, T., Pearlson, G. D., & Pekar, J. J. (2001) · Human Brain Mapping · doi:10.1002/hbm.1048 · Cited by 2,994 · see citing works
Self-citationProbabilistic Independent Component Analysis for Functional Magnetic Resonance Imaging
Beckmann, C. F., & Smith, S. M. (2004) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2003.822821 · Cited by 2,707 · see citing works
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
A default mode of brain function: a brief history of an evolving idea
Raichle, M. E., & Snyder, A. Z. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.041 · Cited by 2,173 · see citing works
Buckner, R. L., Snyder, A. Z., Shannon, B. J., LaRossa, G., Sachs, R., Fotenos, A. F., Sheline, Y. I., Klunk, W. E., Mathis, C. A., Morris, J. C., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2177-05.2005 · Cited by 2,140 · see citing works
Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems
Fox, M. D., Corbetta, M., Snyder, A. Z., Vincent, J. L., & Raichle, M. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604187103 · Cited by 2,101 · see citing works
Addis, D. R., Wong, A. T., & Schacter, D. L. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.10.016 · Cited by 1,949 · see citing works
Electrophysiological signatures of resting state networks in the human brain
Mantini, D., Perrucci, M. G., Del Gratta, C., Romani, G. L., & Corbetta, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700668104 · Cited by 1,938 · see citing works
Intrinsic functional architecture in the anaesthetized monkey brain
Vincent, J. L., Patel, G. H., Fox, M. D., Snyder, A. Z., Baker, J. T., Van Essen, D. C., Zempel, J. M., Snyder, L. H., Corbetta, M., & Raichle, M. E. (2007) · Nature · doi:10.1038/nature05758 · Cited by 1,786 · see citing works
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630 · see citing works
Fransson, P. (2005) · Human Brain Mapping · doi:10.1002/hbm.20113 · Cited by 1,388 · see citing works
fMRI resting state networks define distinct modes of long-distance interactions in the human brain
De Luca, M., Beckmann, C. F., De Stefano, N., Matthews, P. M., & Smith, S. M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.035 · Cited by 1,241 · see citing works
Aberrant “Default Mode” Functional Connectivity in Schizophrenia
Garrity, A. G., Pearlson, G. D., McKiernan, K., Lloyd, D., Kiehl, K. A., & Calhoun, V. D. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.450 · Cited by 1,114 · see citing works
Self-citationEEG-correlated fMRI of human alpha activity
Laufs, H., Kleinschmidt, A., Beyerle, A., Eger, E., Salek-Haddadi, A., Preibisch, C., & Krakow, K. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00286-6 · Cited by 1,025 · see citing works
Coherent spontaneous activity identifies a hippocampal-parietal memory network
Vincent, J. L., Snyder, A. Z., Fox, M. D., Shannon, B. J., Andrews, J. R., Raichle, M. E., & Buckner, R. L. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00048.2006 · Cited by 959 · see citing works
Estimating the number of independent components for functional magnetic resonance imaging data
Li, Y., Adalı, T., & Calhoun, V. D. (2007) · Human Brain Mapping · doi:10.1002/hbm.20359 · Cited by 912 · see citing works
Self-citationIncreased hippocampal activation in mild cognitive impairment compared to normal aging and AD
Dickerson, B. C., Salat, D. H., Greve, D. N., Chua, E. F., Rand-Giovannetti, E., Rentz, D. M., Bertram, L., Mullin, K., Tanzi, R. E., Blacker, D., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000171450.97464.49 · Cited by 910 · see citing works
Wang, L. Y., Zang, Y., Yong He, A., Liang, M., Zhang, X., Tian, L., Wu, T., Jiang, T., & Li, K. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.033 · Cited by 845 · see citing works
REVIEW: The functional organization of the intraparietal sulcus in humans and monkeys
Grefkes, C., & Fink, G. R. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00426.x · Cited by 753 · see citing works
Tensorial extensions of independent component analysis for multisubject FMRI analysis
Beckmann, C. F., & Smith, S. M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.043 · Cited by 748 · see citing works
Rombouts, S. A. R. B., Barkhof, F., Goekoop, R., Stam, C. J., & Scheltens, P. (2005) · Human Brain Mapping · doi:10.1002/hbm.20160 · Cited by 734 · see citing works
Celone, K., Calhoun, V. D., Dickerson, B. C., Atri, A., Chua, E. F., Miller, S. L., DePeau, K. M., Rentz, D., Selkoe, D. J., Blacker, D., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2250-06.2006 · Cited by 733 · see citing works
Self-citationAltered functional connectivity in early Alzheimer's disease: A resting‐state fMRI study
Wang, K., Liang, M., Wang, L. Y., Tian, L., Zhang, X., Li, K., & Jiang, T. (2006) · Human Brain Mapping · doi:10.1002/hbm.20324 · Cited by 727 · see citing works
Detection of functional connectivity using temporal correlations in MR images
Hampson, M., Peterson, B. S., Skudlarski, P., Gatenby, J. C., & Gore, J. C. (2002) · Human Brain Mapping · doi:10.1002/hbm.10022 · Cited by 699 · see citing works
Alzheimer' Disease as a Disconnection Syndrome?
Delbeuck, X., der Linden, M. V., & Collette, F. (2003) · Neuropsychology Review · doi:10.1023/a:1023832305702 · Cited by 681 · see citing works
Functional connectivity in a baseline resting-state network in autism
Cherkassky, V. L., Kana, R. K., Keller, T. A., & Just, M. A. (2006) · NeuroReport · doi:10.1097/01.wnr.0000239956.45448.4c · Cited by 622 · see citing works
Unrest at rest: Default activity and spontaneous network correlations
Buckner, R. L., & Vincent, J. L. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.010 · Cited by 523 · see citing works
Liang, M., Zhou, Y., Jiang, T., Liu, Z., Tian, L., Liu, H., & Hao, Y. (2006) · Neuroreport · doi:10.1097/01.wnr.0000198434.06518.b8 · Cited by 402 · see citing works
Applications of fMRI in translational medicine and clinical practice
Matthews, P. M., Honey, G. D., & Bullmore, E. T. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1929 · Cited by 323 · see citing works
Perirhinal and parahippocampal cortices of the macaque monkey: Projections to the neocortex
Lavenex, P., SUZUKI, W. A., & Amaral, D. G. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10243 · Cited by 317 · see citing works
Unmixing fMRI with independent component analysis
Calhoun, V. D., & Adalı, T. (2006) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/memb.2006.1607672 · Cited by 309 · see citing works
Self-citationShannon, B. J., & Buckner, R. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2625-04.2004 · Cited by 263 · see citing works
Patterns of Atrophy Differ Among Specific Subtypes of Mild Cognitive Impairment
Whitwell, J. L., Petersen, R. C., Negash, S., Weigand, S. D., Kantarci, K., Ivnik, R. J., Knopman, D. S., Boeve, B. F., Smith, G. E., & Jack, C. R. (2007) · Archives of Neurology · doi:10.1001/archneur.64.8.1130 · Cited by 224 · see citing works
Stoub, T. R., deToledo‐Morrell, L., Stebbins, G. T., Leurgans, S. E., Bennett, D. A., & Shah, R. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603414103 · Cited by 200 · see citing works
Schmithorst, V. J., & Holland, S. K. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20009 · Cited by 169 · see citing works
Alescio‐Lautier, B., Michel, B. F., Herrera, C. G., Ahmadi, A. E., Chambon, C., Touzet, C. F., & Paban, V. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.04.033 · Cited by 139 · see citing works
Meguro, K. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.3.315 · Cited by 119 · see citing works
The functional anatomy of divided attention in amnestic mild cognitive impairment
Dannhauser, T. M., Walker, Z., Stevens, T., Lee, L., Seal, M., & Shergill, S. S. (2005) · Brain · doi:10.1093/brain/awh413 · Cited by 106 · see citing works
Analysis of electrocardiograms during atrial fibrillation
Jacquemet, V., van Oosterom, A., Vesin, J.-M., et al. (2006) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/emb-m.2006.250511 · Cited by 57 · see citing works
Ventromedial temporal lobe anatomy, with comments on Alzheimer's disease and temporal injury
Hoesen, G. W. V. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.331 · Cited by 55 · see citing works
Manjaly, Z. M., Marshall, J. C., Stephan, K. E., et al. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00095-8 · Cited by 46 · see citing works
Blaizot, X., Meguro, K., Millien, I., Baron, J., & Chavoix, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09166.2002 · Cited by 26 · see citing works
Xiong (1999) · doi:10.1002/(sici)1097-0193(1999)8:2/3
Flagged first, then by citations
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<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
Dynamic functional connectivity: Promise, issues, and interpretations
Hutchison, R. M., Womelsdorf, T., Allen, E. A., Bandettini, P. A., Calhoun, V. D., Corbetta, M., Della Penna, S., Duyn, J. H., Glover, G. H., Gonzalez-Castillo, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.079 · Cited by 2,962 · see citing works
Self-citationNeurodegenerative Diseases Target Large-Scale Human Brain Networks
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.024 · Cited by 2,350 · see citing works
Amyloid Precursor Protein Processing and Alzheimer's Disease
O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works
Preclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
Van Dijk, K. R. A., Hedden, T., Venkataraman, A., Evans, K. C., Lazar, S. W., & Buckner, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00783.2009 · Cited by 1,844 · see citing works
Fransson, P., & Marrelec, G. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.059 · Cited by 1,213 · see citing works
Resting-state functional connectivity in neuropsychiatric disorders
Greicius, M. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328306f2c5 · Cited by 1,180 · see citing works
Sperling, R. A., LaViolette, P. S., O'Keefe, K., O'Brien, J., Rentz, D. M., Pihlajamaki, M., Marshall, G., Hyman, B. T., Selkoe, D. J., Hedden, T., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.003 · Cited by 1,027 · see citing works
Zhou, J., Greicius, M. D., Gennatas, E. D., Growdon, M. E., Jang, J. Y., Rabinovici, G. D., Kramer, J. H., Weiner, M., Miller, B. L., & Seeley, W. W. (2010) · Brain · doi:10.1093/brain/awq075 · Cited by 1,016 · see citing works
Brain Imaging in Alzheimer Disease
Johnson, K. A., Fox, N. C., Sperling, R. A., & Klunk, W. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006213 · Cited by 875 · see citing works
The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725 · see citing works
Can structure predict function in the human brain?
Honey, C. J., Thivierge, J.-P., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.071 · Cited by 629 · see citing works
Brain networks and cognitive architectures
Petersen, S. E., & Sporns, O. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.027 · Cited by 553 · see citing works
Abnormalities of intrinsic functional connectivity in autism spectrum disorders
Monk, C. S., Peltier, S. J., Wiggins, J. L., Weng, S.-J., Carrasco, M., Risi, S., & Lord, C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.069 · Cited by 578 · see citing works
Synaptic degeneration in Alzheimer's disease
Arendt, T. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0536-x · Cited by 517 · see citing works
Functional network disruption in the degenerative dementias
Pievani, M., de Haan, W., Wu, T., Seeley, W. W., & Frisoni, G. B. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70158-2 · Cited by 481 · see citing works
Witte, A. V., Kerti, L., Margulies, D. S., & Floel, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0385-14.2014 · Cited by 455 · see citing works
Polanía, R., Paulus, W., & Nitsche, M. A. (2012) · Human Brain Mapping · doi:10.1002/hbm.21380 · Cited by 423 · see citing works
Development of the Brain's Default Mode Network from Wakefulness to Slow Wave Sleep
Sämann, P. G., Wehrle, R., Hoehn, D., Spoormaker, V. I., Peters, H., Tully, C., Holsboer, F., & Czisch, M. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq295 · Cited by 399 · see citing works
Impairments of neural circuit function in Alzheimer's disease
Busche, M. A., & Konnerth, A. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0429 · Cited by 360 · see citing works
Age-related changes in the default mode network are more advanced in Alzheimer disease
Jones, D. T., Machulda, M. M., Vemuri, P., McDade, E. M., Zeng, G., Senjem, M. L., Gunter, J. L., Przybelski, S. A., Avula, R. T., Knopman, D. S., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318233b33d · Cited by 370 · see citing works
The role of the medial prefrontal cortex in cognition, ageing and dementia
Jobson, D. D., Hase, Y., Clarkson, A. N., & Kalaria, R. N. (2021) · Brain Communications · doi:10.1093/braincomms/fcab125 · Cited by 338 · see citing works
Lehmann, M., Ghosh, P. M., Madison, C., Laforce, R., Corbetta-Rastelli, C., Weiner, M. W., Greicius, M. D., Seeley, W. W., Gorno-Tempini, M. L., Rosen, H. J., et al. (2013) · Brain · doi:10.1093/brain/aws327 · Cited by 325 · see citing works
Resting Brain Connectivity: Changes during the Progress of Alzheimer Disease
Zhang, H.-Y., Wang, S.-J., Liu, B., Ma, Z.-L., Yang, M., Zhang, Z.-J., & Teng, G.-J. (2010) · Radiology · doi:10.1148/radiol.10091701 · Cited by 320 · see citing works
Bluhm, R., Williamson, P., Lanius, R., Théberge, J., Densmore, M., Bartha, R., Neufeld, R., & Osuch, E. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2009.02030.x · Cited by 294 · see citing works
Selective aberrant functional connectivity of resting state networks in social anxiety disorder
Liao, W., Chen, H., Feng, Y., Mantini, D., Gentili, C., Pan, Z., Ding, J., Duan, X., Qiu, C., Lui, S., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.010 · Cited by 304 · see citing works
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Mevel, K., Chételat, G., Eustache, F., & Desgranges, B. (2011) · International Journal of Alzheimer’s Disease · doi:10.4061/2011/535816 · Cited by 302 · see citing works
Kelly, C., de Zubicaray, G., Di Martino, A., Copland, D. A., Reiss, P. T., Klein, D. F., Castellanos, F. X., Milham, M. P., & McMahon, K. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0810-09.2009 · Cited by 292 · see citing works
Jacobs, H. I. L., Van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.009 · Cited by 293 · see citing works
Hohenfeld, C., Werner, C. J., & Reetz, K. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.03.013 · Cited by 232 · see citing works
Villain, N., Fouquet, M., Baron, J.-C., Mezenge, F., Landeau, B., de La Sayette, V., Viader, F., Eustache, F., Desgranges, B., & Chetelat, G. (2010) · Brain · doi:10.1093/brain/awq203 · Cited by 237 · see citing works
Ungar, L., Altmann, A., & Greicius, M. D. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-013-9272-x · Cited by 246 · see citing works
Identifying patients with Alzheimer’s disease using resting-state fMRI and graph theory
Khazaee, A., Ebrahimzadeh, A., & Babajani-Feremi, A. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.02.060 · Cited by 234 · see citing works
Test-retest reproducibility of the default-mode network in healthy individuals
Meindl, T., Teipel, S., Elmouden, R., Mueller, S., Koch, W., Dietrich, O., Coates, U., Reiser, M., & Glaser, C. (2010) · Human Brain Mapping · doi:10.1002/hbm.20860 · Cited by 220 · see citing works
Fleisher, A. S., Sherzai, A., Taylor, C., Langbaum, J. B. S., Chen, K., & Buxton, R. B. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.021 · Cited by 217 · see citing works
Suo, C., Singh, M. F., Gates, N., Wen, W., Sachdev, P., Brodaty, H., Saigal, N., Wilson, G. C., Meiklejohn, J., Singh, N., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.19 · Cited by 212 · see citing works
Default mode network dissociation in depressive and anxiety states
Coutinho, J. F., Fernandesl, S. V., Soares, J. M., Maia, L., Gonçalves, Ó. F., & Sampaio, A. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9375-7 · Cited by 203 · see citing works
Specific basal forebrain-cortical cholinergic circuits coordinate cognitive operations
Záborszky, L., Gombkoto, P., Varsanyi, P., Gielow, M. R., Poe, G., Role, L. W., Ananth, M., Rajebhosale, P., Talmage, D. A., Hasselmo, M. E., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1676-18.2018 · Cited by 202 · see citing works
Delamillieure, P., Doucet, G., Mazoyer, B., Turbelin, M.-R., Delcroix, N., Mellet, E., Zago, L., Crivello, F., Petit, L., Tzourio-Mazoyer, N., et al. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.11.014 · Cited by 190 · see citing works
Jordan, D., Ilg, R., Riedl, V., Schorer, A., Grimberg, S., Neufang, S., Omerovic, A., Berger, S., Untergehrer, G., Preibisch, C., et al. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182a7ca92 · Cited by 180 · see citing works
Self-citationFunctional network connectivity in the behavioral variant of frontotemporal dementia
Filippi, M., Agosta, F., Scola, E., Canu, E., Magnani, G., Marcone, A., Valsasina, P., Caso, F., Copetti, M., Comi, G., et al. (2013) · Cortex · doi:10.1016/j.cortex.2012.09.017 · Cited by 177 · see citing works
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease
Araque Caballero, M. Á., Suárez-Calvet, M., Duering, M., Franzmeier, N., Benzinger, T., Fagan, A. M., Bateman, R. J., Jack, C. R., Levin, J., Dichgans, M., et al. (2018) · Brain · doi:10.1093/brain/awy229 · Cited by 179 · see citing works
The potential of functional MRI as a biomarker in early Alzheimer's disease
Sperling, R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.009 · Cited by 187 · see citing works
Influence of meditation on anti-correlated networks in the brain
Josipovic, Z., Dinstein, I., Weber, J., & Heeger, D. J. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00183 · Cited by 160 · see citing works
Increased sleep pressure reduces resting state functional connectivity
Sämann, P. G., Tully, C., Spoormaker, V. I., Wetter, T. C., Holsboer, F., Wehrle, R., & Czisch, M. (2010) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-010-0213-z · Cited by 157 · see citing works
Grothe, M. J., Teipel, S. J., & Initiative, F. T. A. D. N. (2016) · Human Brain Mapping · doi:10.1002/hbm.23018 · Cited by 150 · see citing works
Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer’s disease
Myers, N., Pasquini, L., Göttler, J., Grimmer, T., Koch, K., Ortner, M., Neitzel, J., Mühlau, M., Förster, S., Kurz, A., et al. (2014) · Brain · doi:10.1093/brain/awu103 · Cited by 132 · see citing works
Self-citation<scp>EFNS</scp> task force: the use of neuroimaging in the diagnosis of dementia
Filippi, M., Agosta, F., Barkhof, F., Dubois, B., Fox, N. C., Frisoni, G. B., Jack, C. R., Johannsen, P., Miller, B. L., Nestor, P. J., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03859.x · Cited by 141 · see citing works
Impairments in Cognitive Function and Brain Connectivity in Severe Asymptomatic Carotid Stenosis
Cheng, H.-L., Lin, C.-J., Soong, B.-W., Wang, P.-N., Chang, F.-C., Wu, Y.-T., Chou, K.-H., Lin, C.-P., Tu, P.-C., & Lee, I.-H. (2012) · Stroke · doi:10.1161/strokeaha.111.645614 · Cited by 128 · see citing works
Froeliger, B., Garland, E. L., Kozink, R. V., Modlin, L. A., Chen, N.-K., McClernon, F. J., Greeson, J. M., & Sobin, P. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/680407 · Cited by 116 · see citing works
Bozzali, M., Giulietti, G., Basile, B., Serra, L., Spanò, B., Perri, R., Giubilei, F., Marra, C., Caltagirone, C., & Cercignani, M. (2012) · Human Brain Mapping · doi:10.1002/hbm.21287 · Cited by 107 · see citing works
Koch, K., Myers, N. E., Göttler, J., Pasquini, L., Grimmer, T., Förster, S., Manoliu, A., Neitzel, J., Kurz, A., Förstl, H., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu151 · Cited by 97 · see citing works
Self-citationMetabolic resting-state brain networks in health and disease
Spetsieris, P. G., Ko, J. H., Tang, C. C., Nazem, A., Sako, W., Peng, S., Ma, Y., Dhawan, V., & Eidelberg, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411011112 · Cited by 100 · see citing works
Bai, F., Watson, D. R., Shi, Y., Wang, Y., Yue, C., YuhuanTeng, Wu, D., Yuan, Y., & Zhang, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024271 · Cited by 85 · see citing works
Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis
Shah, D., Jonckers, E., Praet, J., Vanhoutte, G., Delgado y Palacios, R., Bigot, C., D’Souza, D. V., Verhoye, M., & Van der Linden, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084241 · Cited by 82 · see citing works
Pihlajamäki, M., & Sperling, R. A. (2009) · Behavioural Neurology · doi:10.1155/2009/276384 · Cited by 102 · see citing works
Rudrauf, D. (2014) · Advances in Neuroscience · doi:10.1155/2014/462765 · Cited by 74 · see citing works
Grandjean, J., Schroeter, A., He, P., Tanadini, M., Keist, R., Krstic, D., Konietzko, U., Klohs, J., Nitsch, R. M., & Rudin, M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4762-13.2014 · Cited by 70 · see citing works
“Additionally, DMN connectivity was reported affected in subjects at risk of developing AD including patients with mild cognitive impairment (Rombouts et al., 2005; Sorg et al., 2007), in cognitively healthy elders with amyloid deposits (Hedden et al.”
BackgroundTahmasian, M., Shao, J., Meng, C., Grimmer, T., Diehl-Schmid, J., Yousefi, B. H., Förster, S., Riedl, V., Drzezga, A., & Sorg, C. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.165464 · Cited by 66 · see citing works
Self-citationWisner, K. M., Atluri, G., Lim, K. O., & MacDonald, A. W. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.066 · Cited by 66 · see citing works
Cluster-based statistics for brain connectivity in correlation with behavioral measures.
Han, C. E., Yoo, S. W., Seo, S. W., Na, D. L., & Seong, J.-K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072332 · Cited by 49 · see citing works
Vanneste, S., Joos, K., Ost, J., & De Ridder, D. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.11.003 · Cited by 45 · see citing works
Wang, Z., Williams, V. J., Stephens, K. A., Kim, C., Bai, L., Zhang, M., & Salat, D. H. (2020) · Human Brain Mapping · doi:10.1002/hbm.24871 · Cited by 28 · see citing works
Alzheimer's disease biomarkers: correspondence between human studies and animal models
Sabbagh, J. J., Kinney, J. W., & Cummings, J. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.010 · Cited by 27 · see citing works
- Authors
- Sorg, C., Riedl, V., Mühlau, M., Calhoun, V. D., Eichele, T., Läer, L., Drzezga, A., Förstl, H., Kurz, A., Zimmer, C., & Wohlschläger, A. M.
- Affiliations
- Departments of *Psychiatry,
- Munich Center for Neurosciences – Brain and Mind (DE)
- Neurology,
- University of New Mexico (US)
- University of Bergen (NO)
- Technical University of Munich (DE)
- TUM Klinikum (DE)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-11-20
- Volume
- 104
- Issue
- 47
- Pages
- 18760-18765
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2141850
- OpenAlex
- W2007572953
- Cited by
- 1,036
- References
- 58
- Citations by year
- 2026: 22 · 2025: 30 · 2024: 20 · 2023: 34 · 2022: 35 · 2021: 57 · 2020: 46 · 2019: 69 · 2018: 56 · 2017: 61 · 2016: 65 · 2015: 63 · 2014: 86 · 2013: 85 · 2012: 100
- FWCI
- 20.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- Alzheimer's disease, resting-state networks, amnestic mild cognitive impairment, default mode network, functional connectivity, structural connectivity, medial temporal lobe atrophy, hippocampal connectivity, posterior cingulate cortex, early neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Female, Health, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Risk Factors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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