The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Small RNA combination therapy for lung cancer
Open accessAbstract
Significance: Small RNAs can potently and precisely regulate gene expression; as a result, they have tremendous clinical potential. However, effective delivery of small RNAs to solid tumors has remained challenging. Here we report that a lipid/polymer nanoparticle can deliver small RNAs to treat autochthonous tumors in the so-called “KP” mouse model of lung cancer. Nanoparticles formulated with mimics of the p53-regulated miRNA miR-34a downregulated target genes and delayed tumor progression, while nanoparticles formulated with siRNA targeting Kirsten rat sarcoma viral oncogene homolog (siKras) slowed tumor growth and increased apoptosis. Notably, concurrent delivery of miR-34a and siKras increased anti-tumor effects, and led to tumor regression. These results demonstrate that small RNA therapies can impact solid lung tumor growth, and that targeted RNA combination therapies may be used to improve therapeutic response.
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Self-citationA microRNA component of the p53 tumour suppressor network
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Background
Cited by
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639
RAS isoforms and mutations in cancer at a glance
Hobbs, G. A., Der, C. J., & Rossman, K. L. (2016) · Journal of Cell Science · doi:10.1242/jcs.182873 · Cited by 973
The delivery of therapeutic oligonucleotides
Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 854
Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
Buscail, L., Bournet, B., & Cordelier, P. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0245-4 · Cited by 721
Strategies, design, and chemistry in siRNA delivery systems
Dong, Y., Siegwart, D. J., & Anderson, D. G. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.05.004 · Cited by 572
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Metadata
- Authors
- Xue, W., Dahlman, J. E., Tammela, T., Khan, O. F., Sood, S., Dave, A., Cai, W., Chirino, L. M., Yang, G. R., Bronson, R., Crowley, D. G., Sahay, G., Schroeder, A., Langer, R., Anderson, D. G., & Jacks, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-08-11
- Volume
- 111
- Issue
- 34
- Pages
- E3553-61
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2106641840
- Cited by
- 242
- References
- 16
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xue, W., Dahlman, J. E., Tammela, T., Khan, O. F., Sood, S., Dave, A., Cai, W., Chirino, L. M., Yang, G. R., Bronson, R., Crowley, D. G., Sahay, G., Schroeder, A., Langer, R., Anderson, D. G., & Jacks, T. (2014). Small RNA combination therapy for lung cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1412686111
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