The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer
Open accessAbstract
Significance: Aberrant microRNA (miRNA) expression is involved in tumorigenesis, and miR-224 was observed to be up-regulated in certain tumor types. However, the role of miR-224 in the pathogenesis of lung cancer remains poorly understood. Here, we comprehensively analyzed and revealed mechanisms of miR-224 up-regulation and its oncogenic role in nonsmall cell lung cancer (NSCLC). We showed that miR-224 promotes cellular migratory, invasive, and proliferative capacity and tumor growth both in vitro and in vivo. Furthermore, we identified TNFα-induced protein 1 and SMAD4 as targets of miR-224 . In addition, up-regulated miR-224 expression in NSCLC is partially controlled by its promoter region’s hypomethylation and activated ERK signaling. Our finding suggests that targeting miR-224 might be a promising therapeutic strategy in the treatment of NSCLC.
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MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053
Self-citationTargeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Roberts, P. J., & Der, C. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210422 · Cited by 2,788
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., et al. (1996) · Science · doi:10.1126/science.271.5247.350 · Cited by 2,337
A Comprehensive Survey of Ras Mutations in Cancer
Prior, I. A., Lewis, P. D., & Mattos, C. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2612 · Cited by 2,063 · cited 1×
“KRAS mutation is frequently seen in lung ADC (42).”
Background
Cited by
Lung cancer epigenetics: From knowledge to applications
Duruisseaux, M., & Esteller, M. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.09.005 · Cited by 283
Interplay between miRNAs and host genes and their role in cancer
Liu, B., Shyr, Y., Cai, J., & Liu, Q. (2019) · Briefings in Functional Genomics · doi:10.1093/bfgp/elz002 · Cited by 137
KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders
Teng, X., Aouacheria, A., Lionnard, L., Metz, K. A., Soane, L., Kamiya, A., & Hardwick, J. M. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13156 · Cited by 124
Bai, J., Na, H., Hua, X., Wei, Y., Ye, T., Zhang, Y., Jian, G., Zeng, W., Yan, L., & Tang, Q. (2017) · Oncotarget · doi:10.18632/oncotarget.14322 · Cited by 41
Metadata
- Authors
- Cui, R., Meng, W., Sun, H.-L., Kim, T., Ye, Z., Fassan, M., Jeon, Y.-J., Li, B., Vicentini, C., Peng, Y., Lee, T. J., Luo, Z., Liu, L., Xu, D., Tili, E., Jin, V., Middleton, J., Chakravarti, A., Lautenschlaeger, T., & Croce, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-07-17
- Volume
- 112
- Issue
- 31
- Pages
- E4288-97
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1840972770
- Cited by
- 158
- References
- 4
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Cui, R., Meng, W., Sun, H.-L., Kim, T., Ye, Z., Fassan, M., Jeon, Y.-J., Li, B., Vicentini, C., Peng, Y., Lee, T. J., Luo, Z., Liu, L., Xu, D., Tili, E., Jin, V., Middleton, J., Chakravarti, A., Lautenschlaeger, T., & Croce, C. M. (2015). MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1502068112
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