Cited by 172Oral microbiology and periodontitis researchAntimicrobial Peptides and ActivitiesGut microbiota and health

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Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology

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Guo, Lihong, McLean, Jeffrey S., Yang, Youngik, Eckert, Randal, Kaplan, Christopher W., Kyme, Pierre, Sheikh, Omid, Varnum, Brian, Lux, Renate, Shi, Wenyuan, He, Xuesong·2015·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1506207112PMC PMC4475959

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Abstract

One major challenge to studying human microbiome and its associated diseases is the lack of effective tools to achieve targeted modulation of individual species and study its ecological function within multispecies communities. Here, we show that C16G2, a specifically targeted antimicrobial peptide, was able to selectively kill cariogenic pathogen Streptococcus mutans with high efficacy within a human saliva-derived in vitro oral multispecies community. Importantly, a significant shift in the overall microbial structure of the C16G2-treated community was revealed after a 24-h recovery period: several bacterial species with metabolic dependency or physical interactions with S. mutans suffered drastic reduction in their abundance, whereas S. mutans' natural competitors, including health-associated Streptococci, became dominant. This study demonstrates the use of targeted antimicrobials to modulate the microbiome structure allowing insights into the key community role of specific bacterial species and also indicates the therapeutic potential of C16G2 to achieve a healthy oral microbiome.

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Authors: Guo, L., McLean, J. S., Yang, Y., Eckert, R., Kaplan, C. W., Kyme, P., Sheikh, O., Varnum, B., Lux, R., Shi, W., & He, X.
Affiliations: University of California, Los Angeles (US)
J. Craig Venter Institute (US)
C3J Therapeutics (United States) (US)
ORCID: Guo, Lihong
McLean, Jeffrey S.
Yang, Youngik
Lux, Renate
Shi, Wenyuan
He, Xuesong
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2015-06
Volume: 112
Issue: 24
Pages: 7569-7574
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1506207112
PMC: PMC4475959
OpenAlex: W1885633068
Cited by: 172
References: 41
Citations by year: 2026: 12 · 2025: 12 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 13 · 2020: 16 · 2019: 23 · 2018: 13 · 2017: 19 · 2016: 12 · 2015: 4
FWCI: 21.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: HHS | NIH | National Institute of Dental and Craniofacial Research (1-R01-DE020102, 1-R01-DE023810-01)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: antimicrobial peptides, targeted antimicrobial therapy, Streptococcus mutans, oral microbiota, multispecies microbial communities, cariogenic bacteria, microbial ecology, oral health
MeSH terms: Adult, Anti-Bacterial Agents, Dental Caries, Humans, Microbial Sensitivity Tests, Mouth, Saliva, Streptococcus mutans, Biofilms, Antimicrobial Cationic Peptides, Microbiota

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