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Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology
Open accessAbstract
One major challenge to studying human microbiome and its associated diseases is the lack of effective tools to achieve targeted modulation of individual species and study its ecological function within multispecies communities. Here, we show that C16G2, a specifically targeted antimicrobial peptide, was able to selectively kill cariogenic pathogen Streptococcus mutans with high efficacy within a human saliva-derived in vitro oral multispecies community. Importantly, a significant shift in the overall microbial structure of the C16G2-treated community was revealed after a 24-h recovery period: several bacterial species with metabolic dependency or physical interactions with S. mutans suffered drastic reduction in their abundance, whereas S. mutans' natural competitors, including health-associated Streptococci, became dominant. This study demonstrates the use of targeted antimicrobials to modulate the microbiome structure allowing insights into the key community role of specific bacterial species and also indicates the therapeutic potential of C16G2 to achieve a healthy oral microbiome.
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“Recently, a Streptococcus mutans-specific peptide was developed and tested in a model of human saliva, where selective depletion of S. mutans triggered community-wide shifts in major nitrate-reducing and non-nitrate-reducing populations[439].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [439]
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Metadata
- Authors
- Guo, L., McLean, J. S., Yang, Y., Eckert, R., Kaplan, C. W., Kyme, P., Sheikh, O., Varnum, B., Lux, R., Shi, W., & He, X.
- Affiliations
- University of California, Los Angeles (US)
- J. Craig Venter Institute (US)
- C3J Therapeutics (United States) (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-06
- Volume
- 112
- Issue
- 24
- Pages
- 7569-7574
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4475959
- OpenAlex
- W1885633068
- Cited by
- 172
- References
- 41
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 13 · 2020: 16 · 2019: 23 · 2018: 13 · 2017: 19 · 2016: 12 · 2015: 4
- FWCI
- 21.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- HHS | NIH | National Institute of Dental and Craniofacial Research (1-R01-DE020102, 1-R01-DE023810-01)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- antimicrobial peptides, targeted antimicrobial therapy, Streptococcus mutans, oral microbiota, multispecies microbial communities, cariogenic bacteria, microbial ecology, oral health
- MeSH terms
- Adult, Anti-Bacterial Agents, Dental Caries, Humans, Microbial Sensitivity Tests, Mouth, Saliva, Streptococcus mutans, Biofilms, Antimicrobial Cationic Peptides, Microbiota
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