The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury
Abstract
Significance: In this study, we used gene expression analyses to unveil mechanisms underlying NT3-chitosan–induced spinal cord regeneration. Using a powerful bioinformatics tool known as weighted gene coexpression network analysis, we have established gene modules and programs representing various events at different times after spinal cord injury (SCI) and also demonstrated that enhanced new neurogenesis and vascularization, as well as reduced inflammatory responses, are keys to conferring the effect of NT3-chitosan on regeneration. The objectivity of this approach and the use of big data processing have opened a new pathway in SCI research. Such quantitative, objective, and sensitive measures could provide a standardized approach in the future to reveal mechanistic insight into various potential interventions for SCI repair.
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“Our in silico analyses identified CASP-3, CASP-7, and BAK as potential or validated miR-138-5p targets among the pro-apoptotic genes becoming upregulated after SCI [7,9,35,53,54,72].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [35]
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Cites
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Self-citationFunctional organization of the transcriptome in human brain
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“, various pathological events) in the “soup” of an injured spinal cord via transcriptome analyses (14).”
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Cited by
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Hartmann, K., Sepulveda-Falla, D., Rose, I. V. L., Madore, C., Muth, C., Matschke, J., Butovsky, O., Liddelow, S., Glatzel, M., & Krasemann, S. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0735-1 · Cited by 141
Zhang, B., Yan, W., Zhu, Y., Yang, W., Le, W., Chen, B., Zhu, R., & Cheng, L. (2018) · Advanced Materials · doi:10.1002/adma.201705694 · Cited by 113
Self-citationMa, C., Zhang, P., & Shen, Y. (2019) · Journal of Neurorestoratology · doi:10.26599/jnr.2019.9040024 · Cited by 19
Maza, R. M., Barreda-Manso, M. A., Reigada, D., Silván, Á., Muñoz-Galdeano, T., Soto, A., del Águila, Á., & Nieto-Díaz, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071559 · Cited by 12
Metadata
- Authors
- Duan, H., Ge, W., Zhang, A., Xi, Y., Chen, Z., Luo, D., Cheng, Y., Fan, K. S., Horvath, S., Sofroniew, M. V., Cheng, L., Yang, Z., Sun, Y. E., & Li, X.
- Affiliations
- Department of Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China;
- Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095;
- Beijing Friendship Hospital, Capital Medical University, Beijing 100068, China;
- Department of Biochemistry and Molecular Biology, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China;
- Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;
- Department of Computer Engineering, University of California Santa Barbara, Santa Barbara, CA 93106;
- Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095;
- Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095;
- Department of Spine Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-10-12
- Volume
- 112
- Issue
- 43
- Pages
- 13360-13365
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 115
- References
- 4
- Language
- en
- Funders
- The State Key Program of National Science Foundation of China (31130022)
- The National 863 Project (2012AA020506)
- The National Ministry of Education Special Fund for Excellent Doctoral Dissertation (201356)
- The National and Technology Pillar Program of China (2012BAI17BO4)
- The international Cooperation in Science and Technology Projects of Ministry of Science and Technology of China (2014DFA30640)
- The Special Funds for Excellent Doctoral Dissertation of Beijing,China (20111000601)
- The Key Project of Department of Science and Technology of Beijing,China (D090800046609004)
- The National Nature Foundation of China (31320103903)
- the trranscriptome and epigenetics core of centre for study of opioid receptors and drugs of abuse (NIH-P50DA005010)
- Intellectual and Developmental Disabilities Research Centre (NIH-P30HD004612)
- National Nature Science Foundation of China (313101021, 31271037)
- The National Nature Science Foundation of China (31271371)
- The National Nature Science of Foundation of China (81330030, 9139309)
- 973 Project (2012CB966303)
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- Duan, H., Ge, W., Zhang, A., Xi, Y., Chen, Z., Luo, D., Cheng, Y., Fan, K. S., Horvath, S., Sofroniew, M. V., Cheng, L., Yang, Z., Sun, Y. E., & Li, X. (2015). Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1510176112
