The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Label-free DNA imaging in vivo with stimulated Raman scattering microscopy
Open accessAbstract
Significance: Microscopic imaging of DNA has to rely on the use of fluorescent staining, an exogenous labeling in biological and biomedical studies, which often leads to uncertainty with respect to the quality and homogeneity of the staining. Label-free imaging of DNA will enable noninvasive visualization of live cell nuclei in both human and animals. Spontaneous Raman microspectroscopy offers label-free chemical contrast for DNA imaging; however, its slow imaging speed hampers its wide application for in vivo and dynamic studies. Here we developed a novel and simple approach with multicolor stimulated Raman scattering microscopy to evaluate rapid DNA imaging, which can be applied to both in vivo DNA dynamic studies and instant label-free human skin cancer diagnosis.
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Cited by
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Self-citationVirtual histological staining of unlabelled tissue-autofluorescence images via deep learning
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Metadata
- Authors
- Lu, F.-K., Basu, S., Igras, V., Hoang, M. P., Ji, M., Fu, D., Holtom, G. R., Neel, V. A., Freudiger, C. W., Fisher, D. E., & Xie, X. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-08-31
- Volume
- 112
- Issue
- 37
- Pages
- 11624-11629
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1934742112
- Cited by
- 302
- References
- 51
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Lu, F.-K., Basu, S., Igras, V., Hoang, M. P., Ji, M., Fu, D., Holtom, G. R., Neel, V. A., Freudiger, C. W., Fisher, D. E., & Xie, X. S. (2015). Label-free DNA imaging in vivo with stimulated Raman scattering microscopy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1515121112
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