Proteostasis and the Aging Proteome in Health and Disease

Autophagy fights disease through cellular self-digestion

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Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

Lecker, S. H., Goldberg, A. L., & Mitch, W. E. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010083 · Cited by 1,234 · see citing works

Endoplasmic reticulum stress in liver disease

Malhi, H., & Kaufman, R. J. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.11.005 · Cited by 1,178 · see citing works

The impact of the unfolded protein response on human disease

Wang, S., & Kaufman, R. J. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201110131 · Cited by 983 · see citing works

Autophagy gone awry in neurodegenerative diseases

Wong, E. S. P., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 883 · see citing works

Endoplasmic Reticulum Stress and Type 2 Diabetes

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Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527 · see citing works

Cellular Strategies of Protein Quality ControlPreprint

Chen, B., Retzlaff, M., Roos, T. R., & Frydman, J. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004374 · Cited by 499 · see citing works

Protein Homeostasis and Aging: the importance of exquisite quality control

Koga, H., Kaushik, S., & Cuervo, A. M. (2011) · Ageing research reviews · doi:10.1016/j.arr.2010.02.001 · Cited by 476 · see citing works

Pharmacological approaches to restore mitochondrial function

Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383 · see citing works

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets

Spiess, C., Meyer, A. S., Reißmann, S., & Frydman, J. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.09.015 · Cited by 377 · see citing works

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

Goldberg, A. L. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350012 · Cited by 370 · see citing works

Signaling the mitochondrial unfolded protein response

Pellegrino, M. W., Nargund, A. M., & Haynes, C. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.02.019 · Cited by 359 · see citing works

The Ribosome as a Hub for Protein Quality Control

Pechmann, S., Willmund, F., & Frydman, J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.020 · Cited by 269 · see citing works

Quality Control of Mitochondrial ProteostasisPreprint

Baker, M. J., Tatsuta, T., & Langer, T. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007559 · Cited by 260 · see citing works

The Stress of Protein Misfolding: From Single Cells to Multicellular OrganismsPreprint

Gidalevitz, T., Prahlad, V., & Morimoto, R. I. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009704 · Cited by 254 · see citing works

Autophagy in health and disease. 5. Mitophagy as a way of life

Gottlieb, R. A., & Carreira, R. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00097.2010 · Cited by 228 · see citing works

Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling

van Oosten‐Hawle, P., Porter, R. S., & Morimoto, R. I. (2013) · Cell · doi:10.1016/j.cell.2013.05.015 · Cited by 197 · see citing works

Autophagy in Health and Disease

Gözüaçık, D. (2013) · Elsevier eBooks · doi:10.1016/c2010-0-66523-0 · Cited by 194 · see citing works

Protein Homeostasis in Models of Aging and Age-Related Conformational Disease

Kikis, E. A., Gidalevitz, T., & Morimoto, R. I. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7002-2_11 · Cited by 187 · see citing works

Chaperone networks: Tipping the balance in protein folding diseases

Voisine, C., Pedersen, J. S., & Morimoto, R. I. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.05.007 · Cited by 163 · see citing works

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

del Álamo, M., Hogan, D. J., Pechmann, S., Albanèse, V., Brown, P. O., & Frydman, J. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001100 · Cited by 158 · see citing works

Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave

Morimoto, R. I., & Cuervo, A. M. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln071 · Cited by 151 · see citing works

Targeting endoplasmic reticulum stress in metabolic disease

Cao, S. S., & Kaufman, R. J. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.756471 · Cited by 149 · see citing works

Mitochondrial turnover in the heart

Gottlieb, R. A., & Gustafsson, Å. B. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.11.017 · Cited by 135 · see citing works

Selective Autophagy: Talking with the UPS

Park, C., & Cuervo, A. M. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9623-7 · Cited by 111 · see citing works

Protein Homeostasis as a Therapeutic Target for Diseases of Protein Conformation

Calamini, B., & Morimoto, R. I. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026611212220014 · Cited by 91 · see citing works

Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases

Ryno, L. M., Wiseman, R. L., & Kelly, J. W. (2013) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2013.04.009 · Cited by 75 · see citing works

XIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancer

Li, M., Song, T., Yin, Z.-F., & Na, Y.-Q. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200703020-00007 · Cited by 59 · see citing works

Mitochondrial Therapeutics for Cardioprotection

Carreira, R., Lee, P. P. W., & Gottlieb, R. A. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211796904777 · Cited by 47 · see citing works

Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses

van Oosten‐Hawle, P., & Morimoto, R. I. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.091249 · Cited by 47 · see citing works

New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis.

Liu, C., Goldberg, A. L., & Qiu, X. (2007) · PubMed · Cited by 38 · see citing works

Unfolded protein responses in bacteria and mitochondria: A central role for the ClpXP machine

Truscott, K. N., Bezawork‐Geleta, A., & Dougan, D. A. (2011) · IUBMB Life · doi:10.1002/iub.526 · Cited by 38 · see citing works

The life of proteins: the good, the mostly good and the ugly

Morimoto, R., Driessen, A., Hegde, R., & Langer, T. (2011) · Nature Structural &Molecular Biology · doi:10.1038/nsmb0111-1 · Cited by 28 · see citing works

Treating the Periphery to Ameliorate Neurodegenerative Diseases

Reinhart, P. H., & Kelly, J. W. (2011) · Cell · doi:10.1016/j.cell.2011.05.031 · Cited by 13 · see citing works

Tau in physiology and pathology

Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

Proteostasis and aging

Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899 · see citing works

Measuring biological aging in humans: a quest

Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781 · see citing works

The aging lung: Physiology, disease, and immunity

Schneider, J. L., Rowe, J. H., Garcia-de-Alba, C., Kim, C. F., Sharpe, A. H., & Haigis, M. C. (2021) · Cell · doi:10.1016/j.cell.2021.03.005 · Cited by 500 · see citing works

Atrial fibrillation

Brundel, B. J. J. M., Ai, X., Hills, M. T., Kuipers, M. F., Lip, G. Y. H., & de Groot, N. M. S. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00347-9 · Cited by 528 · see citing works

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

Bourdenx, M., Martín-Segura, A., Scrivo, A., Rodriguez-Navarro, J. A., Kaushik, S., Tasset, I., Diaz, A., Storm, N. J., Xin, Q., Juste, Y. R., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.048 · Cited by 337 · see citing works

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276 · see citing works

Interplay of pathogenic forms of human tau with different autophagic pathways

Caballero, B., Wang, Y., Diaz, A., Tasset, I., Juste, Y. R., Stiller, B., Mandelkow, E., Mandelkow, E., & Cuervo, A. M. (2018) · Aging Cell · doi:10.1111/acel.12692 · Cited by 213 · see citing works

The Ubiquitin–Proteasome System in Immune Cells

Çetin, G., Klafack, S., Studencka‐Turski, M., Krüger, E., & Ebstein, F. (2021) · Biomolecules · doi:10.3390/biom11010060 · Cited by 210 · see citing works

ER stress and impaired autophagy flux in neuronal degeneration and brain injury

Yin, Y., Sun, G., Li, E., Kiselyov, K. I., & Sun, D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.008 · Cited by 212 · see citing works

The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life SpanPreprint

Sierra, F. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025163 · Cited by 213 · see citing works

The relationship of autophagy defects to cartilage damage during joint aging in a mouse model

Caramés, B., Olmer, M., Kiosses, W. B., & Lotz, M. K. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39073 · Cited by 204 · see citing works

Proteostasis in cardiac health and disease

Henning, R. H., & Brundel, B. J. J. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.89 · Cited by 193 · see citing works

Inflammaging and Cancer: A Challenge for the Mediterranean Diet

Ostan, R., Lanzarini, C., Pini, E., Scurti, M., Vianello, D., Bertarelli, C., Fabbri, C., Izzi, M., Palmas, M. G., Biondi, F., et al. (2015) · Nutrients · doi:10.3390/nu7042589 · Cited by 194 · see citing works

Sirtuins at the crossroads of stemness, aging, and cancer

O'Callaghan, C., & Vassilopoulos, A. (2017) · Aging Cell · doi:10.1111/acel.12685 · Cited by 187 · see citing works

Age-related macular degeneration: A two-level model hypothesis

Rozing, M. P., Durhuus, J. A., Nielsen, M. K., Subhi, Y., Kirkwood, T. B. L., Westendorp, R. G., & Sørensen, T. L. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.100825 · Cited by 183 · see citing works

Heat shock proteins in neurodegenerative disorders and aging

Leak, R. K. (2014) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-014-0243-9 · Cited by 170 · see citing works

Blue Journal Conference. Aging and Susceptibility to Lung Disease

Thannickal, V. J., Murthy, M., Balch, W. E., Chandel, N. S., Meiners, S., Eickelberg, O., Selman, M., Pardo, A., White, E. S., Levy, B. D., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201410-1876pp · Cited by 164 · see citing works

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

Yang, L., Licastro, D., Cava, E., Veronese, N., Spelta, F., Rizza, W., Bertozzi, B., Villareal, D. T., Hotamışlıgil, G. S., Holloszy, J. O., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.042 · Cited by 167 · see citing works

Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons

Nekrasov, E. D., Vigont, V. A., Klyushnikov, S. A., Lebedeva, O. S., Vassina, E. M., Bogomazova, A. N., Chestkov, I. V., Semashko, T. A., Владимировна, К. Е., Suldina, L. A., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0092-5 · Cited by 156 · see citing works

Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease

Martinez, B., Petersen, D., Gaeta, A. L., Stanley, S. P., Caldwell, G. A., & Caldwell, K. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1294-17.2017 · Cited by 146 · see citing works

Circulating Proteomic Signatures of Chronological Age

Menni, C., Kiddle, S. J., Mangino, M., Viñuela, A., Psatha, M., Steves, C., Sattlecker, M., Buil, A., Newhouse, S., Nelson, S., et al. (2015) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glu121 · Cited by 144 · see citing works

Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases

Dattilo, S., Mancuso, C., Koverech, G., Mauro, P. D., Ontario, M. L., Petralia, C. C. T., Petralia, A., Maiolino, L., Serra, A., Calabrese, E. J., et al. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0046-8 · Cited by 140 · see citing works

Impaired proteostasis during skeletal muscle aging

Fernando, R., Drescher, C., Nowotny, K., Grune, T., & Castro, J. P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.037 · Cited by 134 · see citing works

Sirtuins and FoxOs in osteoporosis and osteoarthritis

Almeida, M., & Porter, R. M. (2019) · Bone · doi:10.1016/j.bone.2019.01.018 · Cited by 129 · see citing works

Multifaceted deregulation of gene expression and protein synthesis with age

Anisimova, A. S., Meerson, M., Gerashchenko, M. V., Kulakovskiy, I. V., Dmitriev, S. E., & Gladyshev, V. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2001788117 · Cited by 131 · see citing works

Restricted access: spatial sequestration of damaged proteins during stress and aging

Hill, S. M., Hanzén, S., & Nyström, T. (2017) · EMBO Reports · doi:10.15252/embr.201643458 · Cited by 115 · see citing works

Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

Bobkova, N. V., Evgen’ev, M., Garbuz, D. G., Kulikov, A. M., Morozov, A., Samokhin, A., Velmeshev, D., Medvinskaya, N., Nesterova, I., Pollock, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516131112 · Cited by 118 · see citing works

Editorial: The HSP70 Molecular Chaperone Machines

Goloubinoff, P. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00001 · Cited by 104 · see citing works

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Stacchiotti, A., & Corsetti, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.555409 · Cited by 105 · see citing works

Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease

Bustamante, H. A., González, A., Cerda‐Troncoso, C., Shaughnessy, R., Carola Otth, L., Soza, A., & Burgos, P. V. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00126 · Cited by 98 · see citing works

Frailty biomarkers in humans and rodents: Current approaches and future advances

Kane, A. E., & Sinclair, D. A. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.03.007 · Cited by 101 · see citing works

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging

Cabral-Miranda, F., Tamburini, G., Martínez, G., Ardiles, Á. O., Medinas, D. B., Gerakis, Y., Hung, M., Vidal, R. L., Fuentealba, M., Miedema, T., et al. (2022) · EMBO Journal · doi:10.15252/embj.2022111952 · Cited by 80 · see citing works

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

Hernández, I., Luna, G., Rauch, J. N., Reis, S. A., Giroux, M., Karch, C. M. M., Boctor, D., Sibih, Y., Storm, N. J., Díaz, A., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat3005 · Cited by 95 · see citing works

Translation elongation rate varies among organs and decreases with age

Gerashchenko, M. V., Péterfi, Z., Yim, S. H., & Gladyshev, V. N. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1103 · Cited by 95 · see citing works

Extensive accumulation of misfolded protein aggregates during natural aging and senescence

Cuanalo-Contreras, K., Schulz, J., Mukherjee, A., Park, K.-W., Armijo, E., & Soto, C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1090109 · Cited by 92 · see citing works

Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species

Pride, H., Yu, Z., Sunchu, B., Mochnick, J., Coles, A., Zhang, Y., Buffenstein, R., Hornsby, P. J., Austad, S. N., & Pérez, V. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.046 · Cited by 91 · see citing works

Proteomics and metabolomics in ageing research: from biomarkers to systems biology

Hoffman, J. M., Lyu, Y., Pletcher, S. D., & Promislow, D. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160083 · Cited by 90 · see citing works

Interventions for age-related diseases: Shifting the paradigm

Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 87 · see citing works

ER Stress Response in Human Cellular Models of Senescence

Matos, L., Gouveia, A., & Almeida, H. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu129 · Cited by 88 · see citing works

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

Silva, M. C., & Haggarty, S. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238948 · Cited by 87 · see citing works

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

Vonk, W. I. M., Rainbolt, T. K., Dolan, P. T., Webb, A. E., Brunet, A., & Frydman, J. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.009 · Cited by 84 · see citing works

A distinct astrocyte subtype in the aging mouse brain characterized by impaired protein homeostasis

Lee, E., Jung, Y., Park, Y. R., Lim, S., Choi, Y.-J., Lee, S. Y., Kim, C. H., Mun, J. Y., & Chung, W. (2022) · Nature Aging · doi:10.1038/s43587-022-00257-1 · Cited by 85 · see citing works

Influence of the Mediterranean Diet on Healthy Aging

Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 86 · see citing works

The Amazing Ubiquitin-Proteasome System: Structural Components and Implication in Aging

Tsakiri, E. N., & Trougakos, I. P. (2014) · International review of cytology · doi:10.1016/bs.ircmb.2014.09.002 · Cited by 78 · see citing works

Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease

Bobela, W., Aebischer, P., & Schneider, B. L. (2015) · Biomolecules · doi:10.3390/biom5042675 · Cited by 75 · see citing works

Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls

Ayyadevara, S., Balasubramaniam, M., Parcon, P. A., Barger, S. W., Griffin, W. S. T., Alla, R., Tackett, A. J., Mackintosh, S. G., Petricoin, E. F., Zhou, W., et al. (2016) · Aging Cell · doi:10.1111/acel.12501 · Cited by 76 · see citing works

UVB-Induced Senescence of Human Dermal Fibroblasts Involves Impairment of Proteasome and Enhanced Autophagic Activity

Cavinato, M. S., Kozieł, R., Romani, N., Weinmüllner, R., Jenewein, B., Hermann, M., Dubrac, S., Ratzinger, G., Grillari, J., Schmuth, M., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw150 · Cited by 76 · see citing works

Coping with Protein Quality Control Failure

Pilla, E., Schneider, K., & Bertolotti, A. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125334 · Cited by 72 · see citing works

The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective

Franceschi, C., Ostan, R., Mariotti, S., Monti, D., & Vitale, G. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00170 · Cited by 72 · see citing works

Aging Fits the Disease Criteria of the International Classification of Diseases

Khaltourina, D. A., Matveyev, Y., Alekseev, A., Cortese, F., & Ioviţă, A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111230 · Cited by 71 · see citing works

The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging

Farr, J. N., & Almeida, M. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3564 · Cited by 69 · see citing works

Small heat-shock proteins and their role in mechanical stress

Collier, M. P., & Benesch, J. L. P. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01095-z · Cited by 65 · see citing works

Unraveling the Role of Heme in Neurodegeneration

Chiabrando, D., Fiorito, V., Petrillo, S., & Tolosano, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00712 · Cited by 65 · see citing works

Too sweet: Problems of protein glycation in the eye

Bejarano, E., & Taylor, A. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.08.017 · Cited by 64 · see citing works

Global and tissue-specific aging effects on murine proteomes

Keele, G. R., Zhang, J., Szpyt, J., Korstanje, R., Gygi, S. P., Churchill, G. A., & Schweppe, D. K. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112715 · Cited by 63 · see citing works

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

Raz, Y., Guerrero‐Ros, I., Maier, A. B., Slagboom, P. E., Atzmon, G., Barzilai, N., & Macián, F. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx020 · Cited by 63 · see citing works

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?

Faustini, G., Bono, F., Valerio, A., Pizzi, M., Spano, P., & Bellucci, A. (2017) · Genes · doi:10.3390/genes8120377 · Cited by 63 · see citing works

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals

Hark, T. J., Rao, N. R., Castillon, C., Basta, T., Smukowski, S. N., Bao, H., Upadhyay, A., Bomba-Warczak, E. K., Nomura, T., O'Toole, E. T., et al. (2020) · Cell Systems · doi:10.1016/j.cels.2020.11.007 · Cited by 59 · see citing works

6-bromo-indirubin-3′-oxime (6BIO), a Glycogen synthase kinase-3β inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence-mediated biomolecular damage in human fibroblasts

Sklirou, A. D., Gaboriaud‐Kolar, N., Papassideri, I. S., Skaltsounis, A., & Trougakos, I. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-11662-7 · Cited by 61 · see citing works

Aging, Metabolism, and Cancer Development: from Peto’s Paradox to the Warburg Effect

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Surviving protein quality control catastrophes – from cells to organisms

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