The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The myokine irisin increases cortical bone mass
Open accessAbstract
Significance: Although exercise is a well known and potent stimulus for new bone formation, and weightlessness or muscle loss characteristically cause bone loss, it has remained unclear how muscle talks to bone, despite their close proximity. Here, we show that a molecule irisin derived from skeletal muscle in response to exercise has profound effects in enhancing mass and improving the geometry and strength specifically of cortical bone, the key function of which is to resist bending and torsion. Trabecular bone, which is a reservoir for bodily calcium, is remarkably spared. Irisin may therefore not only be the molecule responsible for muscle–bone connectivity, but could also become a therapy for sarcopenia and osteoporosis, which occur in tandem in the elderly.
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Citations
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Self-citationWhat we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · cited 2×
“We therefore used a 35-fold lower cumulative weekly dose of r-irisin than that used previously to induce browning (19).”
BackgroundMethodFNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · cited 1×
“5A); this is in line with previous studies (21).”
ResultMultilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593
Self-citationTransdifferentiation properties of adipocytes in the adipose organ
Cinti, S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00183.2009 · Cited by 379
Self-citationReduction in proximal femoral strength due to long-duration spaceflight
Keyak, J. H., Koyama, A. K., LeBlanc, A., Lu, Y., & Lang, T. F. (2009) · Bone · doi:10.1016/j.bone.2008.11.014 · Cited by 236
Johannesdottir, F., Aspelund, T., Siggeirsdottir, K., Jonsson, B. Y., Mogensen, B., Sigurdsson, S., Harris, T. B., Gudnason, V. G., Lang, T. F., & Sigurdsson, G. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9585-6 · Cited by 52
Cited by
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Kim, H., Wrann, C. D., Jedrychowski, M., Vidoni, S., Kitase, Y., Nagano, K., Zhou, C., Chou, J., Parkman, V.-J. A., Novick, S. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.025 · Cited by 638
“These data and previous results from others (Colaianni et al., 2015; Colaianni et al., 2017) suggest that irisin could be a useful target for the treatment of osteoporosis.”
InfluentialRobling, A. G., & Bonewald, L. F. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034332 · Cited by 539
Muscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines
Kirk, B., Feehan, J., Lombardi, G., & Duque, G. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00599-y · Cited by 510
Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs
Scheffer, D. D. L., & Latini, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165823 · Cited by 489
Metadata
- Authors
- Colaianni, G., Cuscito, C., Mongelli, T., Pignataro, P., Buccoliero, C., Liu, P., Lu, P., Sartini, L., Di Comite, M., Mori, G., Di Benedetto, A., Brunetti, G., Yuen, T., Sun, L., Reseland, J. E., Colucci, S., New, M. I., Zaidi, M., Cinti, S., & Grano, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-09-15
- Volume
- 112
- Issue
- 39
- Pages
- 12157-12162
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2179357850
- Cited by
- 515
- References
- 9
- FWCI
- 11.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The myokine irisin increases cortical bone mass. https://app.cochat.ai/papers/10.1073/pnas.1516622112
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- Colaianni, G., Cuscito, C., Mongelli, T., Pignataro, P., Buccoliero, C., Liu, P., Lu, P., Sartini, L., Di Comite, M., Mori, G., Di Benedetto, A., Brunetti, G., Yuen, T., Sun, L., Reseland, J. E., Colucci, S., New, M. I., Zaidi, M., Cinti, S., & Grano, M. (2015). The myokine irisin increases cortical bone mass. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1516622112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
