Microsatellite instability: a review of what the oncologist should know
Open accessAbstract
The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can benefit from immunotherapy, and MSI can be used as a genetic instability of a tumor detection index. However, many studies have shown that there are many heterogeneous phenomena in patients with MSI tumors in terms of immunotherapy, prognosis and chemotherapy sensitivity. Here we mainly review the research results of MSI detection methods, the mechanisms of MSI occurrence and its relationship with related tumors, aiming to make a brief analysis of the current research status of MSI and provide comparable reference and guidance value for further research in this field.
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A line of work has focused on developing and validating AI for predicting microsatellite instability, a feature associated with clinical outcomes and a biomarker for immunotherapy.
“a line of work (97-99) has focused on developing and validating AI for predicting microsatellite instability (MSI), a feature associated with clinical outcomes and a biomarker for immunotherapy (100).”
From Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions (2024) · cites this paper as [100]
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Self-citationHause, R. J., Pritchard, C. C., Shendure, J., et al. (2018) · Nature Medicine · doi:10.1038/nm0418-525a · Cited by 20 · see citing works
No evidence for microsatellite instability in acute myeloid leukemia
Walker, C. J., Eisfeld, A.-K., Genutis, L. K., et al. (2017) · Leukemia · doi:10.1038/leu.2017.97 · Cited by 15 · see citing works
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Microsatellite instability & survival in patients with stage II/III colorectal carcinoma
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Microsatellite instability profiling in Egyptian bladder cancer patients: A pilot study
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Nivolumab plus Ipilimumab Achieves Responses in dMMR/MSI-H Tumors
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Integrating Immunotherapy Into Colorectal Cancer Care.
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Assessment of microsatellite instability for screening bladder cancer in high-risk population
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First Comprehensive Companion Diagnostic OK'd
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Flagged first, then by citations
Cited by
Sorted by citations
Immune Checkpoint Inhibitors in Cancer Therapy
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Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions
Lotter, W., Hassett, M. J., Schultz, N., Kehl, K. L., Van Allen, E. M., & Cerami, E. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1199 · Cited by 196 · see citing works
Autophagy: A Versatile Player in the Progression of Colorectal Cancer and Drug Resistance
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FOXP3 recognizes microsatellites and bridges DNA through multimerization
Zhang, W., Leng, F., Wang, X., Ramirez, R. N., Park, J., Benoist, C., & Hur, S. (2023) · Nature · doi:10.1038/s41586-023-06793-z · Cited by 42 · see citing works
“While widely used as genetic tracing markers due to their high degrees of polymorphism, reports of the biological functions of microsatellites 30,31 , besides their well-known pathogenic roles 32–35 , remain sparse 36,37 .”
BackgroundRefining patient selection for breast cancer immunotherapy: beyond PD-L1
Kossai, M., Radosevic-Robin, N., & Penault-Llorca, F. (2021) · ESMO Open · doi:10.1016/j.esmoop.2021.100257 · Cited by 36 · see citing works
- Authors
- Li, K., Luo, H., Huang, L., Luo, H., & Zhu, X.
- Affiliations
- Guangdong Medical College (CN)
- Corresponding author
- Luo, Haiqing
- Luo, Hui
- Zhu, Xiao
- Venue
- Cancer Cell International
- Published
- 2020-01-13
- Volume
- 20
- Issue
- 1
- Pages
- 16-16
- ISSN
- 1475-2867 (ISSN-L)
- PMC
- PMC6958913
- OpenAlex
- W3005521521
- Cited by
- 509
- References
- 101
- Citations by year
- 2026: 28 · 2025: 97 · 2024: 94 · 2023: 115 · 2022: 87 · 2021: 61 · 2020: 26 · 2013: 1
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer Cell International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81541153)
- Southern Science and Engineering Guangdong Laboratory Zhanjiang (ZJW-2019-07)
- The Public Service Platform of South China for R&D Biomedicine Resources (GDMUK201808)
- Guangdong Provincial Science and Technology Programs (2016A050503046, 2015A050502048, 2016B030309002)
- Zhanjiang Science and Technology Plan (2017A06012)
- “Group-type” Special Supporting Project for Educational Talents in Universities (4SG19057G)
- Natural Science Foundation of Guangdong Province (2018A030310155)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- microsatellite instability, mismatch repair deficiency, immunotherapy response, prognosis, chemosensitivity, cancer types
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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