The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
CXCL13 is a plasma biomarker of germinal center activity
Open accessAbstract
Significance: A major challenge for vaccine science is that there is no way to measure germinal center activity in humans. This challenge is particularly acute for human clinical trials of candidate vaccines (and most nonhuman primate studies of candidate vaccines), because germinal centers are the engines of Ab affinity maturation, and generation of highly affinity-matured Ab responses is the goal of all Ab-eliciting vaccines. Here, we report that we have identified the chemokine CXCL13 [chemokine (C-X-C motif) ligand 13] as a biomarker of germinal center activity. We show explicit relationships between plasma CXCL13 concentrations and germinal center frequencies in lymph nodes in a series of different conditions, including licensed and experimental vaccines, and in humans, nonhuman primates, and mice.
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Cites
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T follicular helper cell differentiation, function, and roles in disease
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Self-citationA chemokine-driven positive feedback loop organizes lymphoid follicles
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Germinal-Center Organization and Cellular Dynamics
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Programming the magnitude and persistence of antibody responses with innate immunity
Kasturi, S. P., Skountzou, I., Albrecht, R. A., Koutsonanos, D., Hua, T., Nakaya, H. I., Ravindran, R., Stewart, S., Alam, M., Kwissa, M., et al. (2011) · Nature · doi:10.1038/nature09737 · Cited by 975
Self-citationLocci, M., Havenar-Daughton, C., Landais, E., Wu, J., Kroenke, M. A., Arlehamn, C. L., Su, L. F., Cubas, R., Davis, M. M., Sette, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.031 · Cited by 868
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Bentebibel, S.-E., Lopez, S., Obermoser, G., Schmitt, N., Mueller, C., Harrod, C., Flano, E., Mejias, A., Albrecht, R. A., Blankenship, D., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005191 · Cited by 597
Cited by
T follicular helper cell biology: a decade of discovery and diseases
Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591
Self-citationInflammation and immunity in IPF pathogenesis and treatment
Heukels, P., Moor, C. C., von der Thüsen, J. H., Wijsenbeek, M. S., & Kool, M. (2019) · Respiratory Medicine · doi:10.1016/j.rmed.2018.12.015 · Cited by 517
Early B cell changes predict autoimmunity following combination immune checkpoint blockade
Das, R., Bar, N., Ferreira, M., Newman, A. M., Zhang, L., Bailur, J. K., Bacchiocchi, A., Kluger, H., Wei, W., Halaban, R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96798 · Cited by 423
CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer
Gu-Trantien, C., Migliori, E., Buisseret, L., de Wind, A., Brohée, S., Garaud, S., Noël, G., Dang Chi, V. L., Lodewyckx, J.-N., Naveaux, C., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.91487 · Cited by 368
Reiss, S., Baxter, A. E., Cirelli, K. M., Dan, J. M., Morou, A., Daigneault, A., Brassard, N., Silvestri, G., Routy, J.-P., Havenar-Daughton, C., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186998 · Cited by 343
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Metadata
- Authors
- Havenar-Daughton, C., Lindqvist, M., Heit, A., Wu, J. E., Reiss, S. M., Kendric, K., Bélanger, S., Kasturi, S. P., Landais, E., Akondy, R. S., McGuire, H. M., Bothwell, M., Vagefi, P. A., Scully, E., IAVI Protocol C Principal Investigators, Tomaras, G. D., Davis, M. M., Poignard, P., Ahmed, R., Walker, B. D., Pulendran, B., McElrath, M. J., Kaufmann, D. E., Crotty, S., Price, M. A., Gilmour, J., Fast, P., Kamali, A., Sanders, E. J., Onzala, O., Allen, S., Hunter, E., Karita, E., Kilembe, W., Lakhi, S., & Inambao, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-02-23
- Volume
- 113
- Issue
- 10
- Pages
- 2702-2707
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2286883753
- Cited by
- 353
- References
- 48
- FWCI
- 20.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: CXCL13 is a plasma biomarker of germinal center activity. https://app.cochat.ai/papers/10.1073/pnas.1520112113
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- Havenar-Daughton, C., Lindqvist, M., Heit, A., Wu, J. E., Reiss, S. M., Kendric, K., Bélanger, S., Kasturi, S. P., Landais, E., Akondy, R. S., McGuire, H. M., Bothwell, M., Vagefi, P. A., Scully, E., IAVI Protocol C Principal Investigators, Tomaras, G. D., Davis, M. M., Poignard, P., Ahmed, R., . . . Inambao, M. (2016). CXCL13 is a plasma biomarker of germinal center activity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1520112113
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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