The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species
Open accessAbstract
Significance: Mechanisms of competition are not well-studied in the mammalian gut microbiota, especially among abundant species of this ecosystem. Theoretical models predict that antagonistic mechanisms should profoundly affect member fitness, yet identification and experimental analyses of such factors are few. Here we show that the abundant gut species Bacteroides fragilis produce T6SSs that deploy previously undescribed toxins able to antagonize numerous species of human gut Bacteroidales. We show that these systems are synthesized in the mammalian gut and allow a producing strain to outcompete a sensitive isogenic strain. Our data support that GA3 T6SSs likely allow the producing B. fragilis strain to create a protected niche in the human colon.
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Cites
The Long-Term Stability of the Human Gut Microbiota
Faith, J. J., Guruge, J. L., Charbonneau, M., Subramanian, S., Seedorf, H., Goodman, A. L., Clemente, J. C., Knight, R., Heath, A. C., Leibel, R. L., et al. (2013) · Science · doi:10.1126/science.1237439 · Cited by 2,058
Immunochemical characterization of two surface polysaccharides of Bacteroides fragilis
Pantosti, A., Tzianabos, A. O., Onderdonk, A. B., & Kasper, D. L. (1991) · Infection and Immunity · doi:10.1128/iai.59.6.2075-2082.1991 · Cited by 110
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Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens
Kim, S., Covington, A., & Pamer, E. G. (2017) · Immunological Reviews · doi:10.1111/imr.12563 · Cited by 741
An insider's perspective: Bacteroides as a window into the microbiome
Wexler, A. G., & Goodman, A. L. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.26 · Cited by 641
Microbiota-mediated colonization resistance: mechanisms and regulation
Caballero-Flores, G., Pickard, J. M., & Núñez, G. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00833-7 · Cited by 474
Why does the microbiome affect behaviour?
Johnson, K. V.-A., & Foster, K. R. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0014-3 · Cited by 333
Metadata
- Authors
- Chatzidaki-Livanis, M., Geva-Zatorsky, N., & Comstock, L. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-03-07
- Volume
- 113
- Issue
- 13
- Pages
- 3627-3632
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2298135825
- Cited by
- 230
- References
- 2
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chatzidaki-Livanis, M., Geva-Zatorsky, N., & Comstock, L. E. (2016). Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1522510113
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