Cited by 238Cancer Cells and MetastasisTGF-β signaling in diseasesAngiogenesis and VEGF in Cancer

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Tumor-associated fibroblasts predominantly come from local and not circulating precursors

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Arina, Ainhoa, Idel, Christian, Hyjek, Elizabeth M., Alegre, Maria-Luisa, Wang, Ying, Bindokas, Vytautas P., Weichselbaum, Ralph R., Schreiber, Hans·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1600363113PMC PMC4941507

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Abstract

Significance: Fibroblasts constitute an important element of tumors and have received considerable attention in recent years due to their tumor-promoting and immunosuppressive properties. As a consequence, tumor-associated fibroblasts (TAFs) are considered an attractive target for cancer therapies. However, their origin remains controversial, with some evidence pointing at a local origin, whereas many publications suggest a significant contribution of progenitors from bone marrow. We found that TAFs derive almost exclusively from local sources. Therefore, therapeutic strategies to target fibroblasts must exploit local recruitment and the unique transcriptional and response patterns of fibroblasts from different sites.

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Authors: Arina, A., Idel, C., Hyjek, E. M., Alegre, M.-L., Wang, Y., Bindokas, V. P., Weichselbaum, R. R., & Schreiber, H.
Affiliations: University of Chicago (US)
Corresponding author: Arina, Ainhoa
ORCID: Arina, Ainhoa
Hyjek, Elizabeth M.
Alegre, Maria-Luisa
Wang, Ying
Bindokas, Vytautas P.
Weichselbaum, Ralph R.
Schreiber, Hans
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2016-06-17
Volume: 113
Issue: 27
Pages: 7551-7556
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1600363113
PMC: PMC4941507
OpenAlex: W2442704894
Cited by: 238
References: 69
Citations by year: 2026: 20 · 2025: 38 · 2024: 35 · 2023: 37 · 2022: 26 · 2021: 29 · 2020: 21 · 2019: 12 · 2018: 12 · 2017: 7 · 2016: 1
FWCI: 5.75
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/preview_site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | National Institutes of Health (P01-CA97296, R01-CA22677, R01-CA37516)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: cancer-associated fibroblasts, tumor stroma, fibroblast origin, type I collagen, parabiosis, bone marrow chimeras, skin grafting, tumor microenvironment, collagen deposition
MeSH terms: Cancer-Associated Fibroblasts, Actins, Animals, Mice, Inbred C57BL, Neoplasms, Experimental, Mice, Knockout, Collagen Type I, Cell Line, Tumor, Green Fluorescent Proteins

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Tumor-associated fibroblasts predominantly come from local and not circulating precursors

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