Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732

Principles of bioactive lipid signalling: lessons from sphingolipids

Hannun, Y. A., & Obeid, L. M. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2329 · Cited by 3,411

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876

A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen

Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T., Luo, B., Grenier, J. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.040 · Cited by 1,804

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631

Lentivirus-delivered stable gene silencing by RNAi in primary cells.

Stewart, S. A., Dykxhoorn, D. M., Palliser, D., Mizuno, H., Yu, E. Y., An, D., Sabatini, D., Chen, I. S. Y., Hahn, W., Sharp, P., et al. (2003) · RNA: A publication of the RNA Society · doi:10.1261/rna.2192803 · Cited by 1,619

Phospholipid dynamics in ex vivo lung cancer and normal lung explants

Lesko, J., Triebl, A., Stacher‐Priehse, E., Fink-Neuböck, N., Lindenmann, J., Smolle‐Jüttner, F., Köfeler, H. C., Hrzenjak, A., Olschewski, H., & Leithner, K. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00547-x · Cited by 41

Ferroptosis Regulation by Nutrient Signalling

Qi, Y., Zhang, X., Wu, Z., Tian, M., Chen, F., Guan, W., & Zhang, S. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000226 · Cited by 42

Ferroptosis plays an important role in promoting ionizing radiation-induced intestinal injuries

Wang, L., Wang, A., Fu, Q., Shi, Z., Chen, X., Wang, Y., Xu, W., Wang, T., Zhang, S., & Hu, S. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.01.068 · Cited by 42

Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment

de Souza, I., Ramalho, M. C. C., Guedes, C. B., Osawa, I. Y. A., Monteiro, L. K. S., Gomes, L. R., & Rocha, C. R. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136879 · Cited by 42

Lipid metabolism in ferroptosis and ferroptosis-based cancer therapy

Sun, Y., Xue, Z., Huang, T., Che, X., & Wu, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.941618 · Cited by 44

The role of ferroptosis in the development of acute and chronic kidney diseases

Zhou, Y., Zhang, J., Guan, Q., Tao, X., Wang, J., & Li, W. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30901 · Cited by 41

Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions

Tan, X., Huang, X., Niu, B., Guo, X., Lei, X., & Qu, B. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1102158 · Cited by 40

Emerging role of ferroptosis in glioblastoma: Therapeutic opportunities and challenges

Zhuo, S., He, G., Chen, T., Li, X., Liang, Y., Wu, W., Weng, L., Feng, J., Gao, Z., & Yang, K. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.974156 · Cited by 45

Ferroptosis: A New Development Trend in Periodontitis

Chen, K., Ma, S., Deng, J., Jiang, X., Ma, F., & Li, Z. (2022) · Cells · doi:10.3390/cells11213349 · Cited by 44

Ferroptosis, autophagy, tumor and immunity

Xie, Y., Zhou, Y., Wang, J., Lijuan, D., Ren, Y., & Liu, F. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19799 · Cited by 40

Ferroptosis: a promising candidate for exosome-mediated regulation in different diseases

Liu, L., Ye, Y., Lin, R., Liu, T., Wang, S., Feng, Z., Wang, X., Cao, H., Chen, X., Miao, J., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01369-w · Cited by 41

Cadmium exposure induced neuronal ferroptosis and cognitive deficits via the mtROS-ferritinophagy pathway

Wang, D., Wu, Y., Zhou, X., Chen, L., Ma, Y., Yuan, Q., Wu, Z., Hao, X., Zhu, X., Li, X., et al. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123958 · Cited by 41

Current Progress of Ferroptosis Study in Hepatocellular Carcinoma

Zhu, X., Sha, X., Zang, Y., Ren, Q., Zhang, S., Ma, D., Wang, L., Yao, J., Zhou, X. Y., Yu, L., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.96014 · Cited by 41

The potential roles of HIF-1α in epithelial-mesenchymal transition and ferroptosis in tumor cells

Shen, Z., Yu, N. H., Zhang, Y., Jia, M., Sun, Y., Li, Y., & Zhao, L. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111345 · Cited by 40

Ferroptosis in Osteoarthritis: Current Understanding

Liu, Y., Zhang, Z., Yuan, F., Liu, C., & Zhang, H. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s493001 · Cited by 41

Ferroptosis meets inflammation: A new frontier in cancer therapy

Liu, H., Xue, H., Guo, Q., Xue, X., Yang, L., Zhao, K., & Liu, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217696 · Cited by 44

Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis

Vučetić, M., Daher, B., Cassim, S., Meira, W., & Pouysségur, J. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02994-w · Cited by 40

Ferroptosis by Lipid Peroxidation: The Tip of the Iceberg?

Chen, X., Kang, R., & Tang, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.646890 · Cited by 40

The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future

Lin, H., Ho, H.-W., Chang, Y., Wei, C.-J., & Chu, P. (2021) · Cancers · doi:10.3390/cancers13184576 · Cited by 41

Ferroptosis—A Novel Mechanism With Multifaceted Actions on Stroke

Fang, X., Ding, S.-Y., Du, X., Wang, J.-H., & Li, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.881809 · Cited by 42

Differential effects of saturated and unsaturated free fatty acids on ferroptosis in rat β-cells

Krümmel, B., von Hanstein, A., Plötz, T., Lenzen, S., & Mehmeti, I. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109013 · Cited by 40

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids

Cui, S., Simmons, G., do Vale, G. D., Deng, Y., Kim, J., Kim, H., Zhang, R., McDonald, J. G., & Ye, J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107189119 · Cited by 42

Redox Dyshomeostasis with Dual Stimuli‐Activatable Dihydroartemisinin Nanoparticles to Potentiate Ferroptotic Therapy of Pancreatic Cancer

Wang, Y., Chen, F., Zhou, H., Huang, L., Ye, J., Liu, X., Sheng, W., Gao, W., Yu, H., & Wang, F. (2022) · Small Methods · doi:10.1002/smtd.202200888 · Cited by 41

The Hemagglutinin of Influenza A Virus Induces Ferroptosis to Facilitate Viral Replication

Ouyang, A., Chen, T., Feng, Y., Zou, J., Tu, S., Jiang, M., Sun, H., & Zhou, H. (2024) · Advanced Science · doi:10.1002/advs.202404365 · Cited by 39

Targeting ferroptosis in autoimmune diseases: Mechanisms and therapeutic prospects

Zheng, Y., Yan, F., He, S., & Luo, L. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103640 · Cited by 42

Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies

Guo, D., Cai, S., Deng, L., Xu, W., Fu, S., Lin, Y., Jiang, T., Li, X., Shen, Z., Zhang, J., et al. (2025) · MedComm · doi:10.1002/mco2.70116 · Cited by 44

A minireview: Role of AMP-activated protein kinase (AMPK) signaling in obesity-related renal injury

Zhuo, L., Li, J. X., Miao, X., Cui, W., Miao, L., & Cai, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118828 · Cited by 40

Ferroptosis-Related Genes in Neurodevelopment and Central Nervous System

Kim, S.-W., Kim, S.-W., Kim, Y.-J., & An, J. (2021) · Biology · doi:10.3390/biology10010035 · Cited by 40

Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer

Tang, W., Xu, F., Zhao, M. L., & Zhang, S. (2021) · BMC Cancer · doi:10.1186/s12885-021-08892-4 · Cited by 39

Contribution of Lipid Oxidation and Ferroptosis to Radiotherapy Efficacy

Pearson, A. N., Carmicheal, J., Jiang, L., Lei, Y. L., & Green, M. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212603 · Cited by 41

Non-coding RNAs in ferroptotic cancer cell death pathway: meet the new masters

Valashedi, M. R., Bamshad, C., Najafi-Ghalehlou, N., Nikoo, A., Tomita, K., Kuwahara, Y., Sato, T., Roushandeh, A. M., & Roudkenar, M. H. (2022) · Human Cell · doi:10.1007/s13577-022-00699-0 · Cited by 39

mTORC1 beyond anabolic metabolism: Regulation of cell death

Zhu, J., Wang, H., & Jiang, X. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202208103 · Cited by 42

The role of ferroptosis in fish inflammation

Gao, F., Shi, X., Pei, C., Zhao, X., Zhu, L., Zhang, J., Li, L., Li, C., & Kong, X. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12719 · Cited by 38

Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs

Zhang, Q., Fan, X., Zhang, X., & Ju, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04370-6 · Cited by 39

Apoptotic signaling: Beyond cell death

Nano, M., & Montell, D. J. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.11.002 · Cited by 40

Ferroptosis resistance in cancer: recent advances and future perspectives

Zhang, X., Li, X., Ran, X., & Zhang, H. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115933 · Cited by 38

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Ge, A., He, Q., Da, Z., Li, Y., Chen, J., Deng, Y., Xiang, W., Fan, H., Wu, S., Li, Y., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18044 · Cited by 40

The role of ferroptosis as a regulator of oxidative stress in the pathogenesis of ischemic stroke

Delgado‐Martín, S., & Martı́nez-Ruiz, A. (2024) · FEBS Letters · doi:10.1002/1873-3468.14894 · Cited by 42

Regulation of FSP1 myristoylation by NADPH: A novel mechanism for ferroptosis inhibition

Liu, N., Wu, W.-L., Wan, X., Wang, J., Huang, J., Jiang, Y., Sheng, Y.-C., Wu, J., Liang, Z., Qin, Z., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103176 · Cited by 38

Neuronal regulated cell death in aging-related neurodegenerative diseases: key pathways and therapeutic potentials

Song, R., Yin, S., Wu, J., & Yan, J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00025 · Cited by 41

Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates

Liu, L., Zheng, Z., You, W., Yang, P., Wen, Y., Qiao, Y., Ma, S., Zhang, H., Zhang, S., Xu, G., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.02.010 · Cited by 41

Vitamin E deficiency during embryogenesis in zebrafish causes lasting metabolic and cognitive impairments despite refeeding adequate diets

McDougall, M. Q., Choi, J., Truong, L., Tanguay, R. L., & Traber, M. G. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.012 · Cited by 37

“Only a Life Lived for Others Is Worth Living”: Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions

Tyurina, Y. Y., Shrivastava, I. H., Tyurin, V. A., Mao, G., Dar, H. H., Watkins, S. C., Epperly, M. W., Bahar, İ., Shvedova, A. A., Pitt, B. R., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7124 · Cited by 38

Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update

Nguyen, T. H. P., Mahalakshmi, B., & Velmurugan, B. K. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108930 · Cited by 37

Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation

Kagan, V. E., Tyurina, Y. Y., Vlasova, I. I., Kapralov, A. A., Amoscato, A. A., Anthonymuthu, T. S., Tyurin, V. A., Shrivastava, I. H., Cinemre, F. B. S., Lamade, A. M., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.628079 · Cited by 39

Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis

Ficiarà, E., Munir, Z., Boschi, S., Caligiuri, M. E., & Guiot, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094479 · Cited by 40

Ferroptosis: A new insight for treatment of acute kidney injury

Li, S., Wang, R., Wang, Y., Liu, Y., Qiao, Y., Li, P., Chen, J., Pan, S., Feng, Q., Liu, Z., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1065867 · Cited by 40

Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

Akiyama, H., Carter, B. Z., Andreeff, M., & Ishizawa, J. (2023) · Cells · doi:10.3390/cells12081128 · Cited by 38

Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA

Labrecque, C. L., & Fuglestad, B. (2021) · Biochemistry · doi:10.1021/acs.biochem.1c00492 · Cited by 35

Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis‐Associated Mechanisms

Ma, T., Zhou, Y., Wang, C., Wang, L., Chen, J., Yang, H., Zhang, C.-Y., Zhou, Y., & Guan, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1098970 · Cited by 62

The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead

Nguyen, K.-A., Conilh, L., Falson, P., Dumontet, C., & Boumendjel, A. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114863 · Cited by 38

Iron as a therapeutic target in chronic liver disease

Kouroumalis, E., Tsomidis, I., & Voumvouraki, A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i4.616 · Cited by 42

Research progress on the mechanism of ferroptosis and its role in diabetic retinopathy

He, W., Lu, C., Li, X., & Mei, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1155296 · Cited by 37

Ferroptosis: a new regulatory mechanism in neuropathic pain

Li, L., Guo, L., Gao, R. C., Yao, M., Qu, X., Sun, G., Fu, Q., Hu, C., & Han, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1206851 · Cited by 38

Radiotherapy-Triggered In Situ Tumor Vaccination Boosts Checkpoint Blockaded Immune Response via Antigen-Capturing Nanoadjuvants

Xu, P., Ma, J., Zhou, Y. C., Gu, Y., Cheng, X., Wang, Y., Wang, Y., & Gao, M. (2023) · ACS Nano · doi:10.1021/acsnano.3c10225 · Cited by 37

Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis

Liu, X., Chen, Z., Yan, Y., Zandkarimi, F., Nie, L., Li, Q., Horbath, A. D., Olszewski, K. L., Kondiparthi, L., Mao, C., et al. (2024) · Protein & Cell · doi:10.1093/procel/pwae004 · Cited by 38

SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation

He, G., Zhang, Y., Feng, Y., Chen, T., Liu, M., Zeng, Y., Yin, X., Qu, S., Huang, L., Ke, Y., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18212 · Cited by 37

Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies

Luan, X., Chen, P., Miao, L., Yuan, X., Yu, C., & Di, G.-H. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04978-2 · Cited by 36

The role of ferroptosis in osteoarthritis: Progress and prospects

Sheng, W., Liao, S., Wang, D., Liu, P., & Zeng, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150683 · Cited by 37

NFE2L2 and ferroptosis resistance in cancer therapy

Tang, D., & Kang, R. (2024) · Cancer Drug Resistance · doi:10.20517/cdr.2024.123 · Cited by 41

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

Shen, G., Liu, J., Wang, Y., Deng, Z., & Deng, F. (2025) · MedComm · doi:10.1002/mco2.70349 · Cited by 47

A new role of glutathione peroxidase 4 during human erythroblast enucleation

Ouled‐Haddou, H., Messaoudi, K., Demont, Y., Santos, R. L. D., Carola, C., Caulier, A., Vong, P., Jankovsky, N., Lebon, D., Willaume, A., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020003100 · Cited by 40

Ferroptosis is Involved in Hyperoxic Lung Injury in Neonatal Rats

Jia, D., Zheng, J., Zhou, Y., Jia, J., Ye, X., Zhou, B., Chen, X., Mo, Y., & Wang, J. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s335061 · Cited by 37

SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway

Wu, F., Xiong, G., Chen, Z., Lei, C., Liu, Q., & Bai, Y. (2022) · Hereditas · doi:10.1186/s41065-022-00225-0 · Cited by 37

Therapeutic Implications of Ferroptosis in Renal Fibrosis

Zhang, Y., Mou, Y., Zhang, J., Suo, C., Zhou, H., Gu, M. J., Wang, Z., & Tan, R. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.890766 · Cited by 38

The interplay of miRNAs and ferroptosis in diseases related to iron overload

Jin, S., Liu, P.-S., Zheng, D., & Xie, X. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01890-w · Cited by 37

Ferroptosis and central nervous system demyelinating diseases

Qin, D., Li, D., Wang, C., & Guo, S. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15831 · Cited by 36

GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

Tu, L., Zhang, T.-Z., Zhou, Y.-F., Zhou, Q., Gong, H., Liang, L., Hai, L.-N., You, N.-X., Su, Y., Chen, Y., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.02.016 · Cited by 38

Striking a NRF2: The Rusty and Rancid Vulnerabilities Toward Ferroptosis in Alzheimer's Disease

Lane, D. J. R., Alves, F. M., Ayton, S., & Bush, A. I. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0318 · Cited by 36

Ferroptosis as a promising therapeutic strategy for melanoma

Ta, N., Jiang, X., Zhang, Y., & Wang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1252567 · Cited by 38

Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications

Zhou, D., Lu, P., Mo, X., Yang, B., Chen, T., Yao, Y., Xiong, T., Lin, Y., & Yang, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1248934 · Cited by 38

Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling

Li, X., Xu, H., Zhao, X., Li, Y., Lv, S., Zhou, W. J., Wang, J., Sun, Z., Li, Y., & Guo, C. (2024) · Particle and Fibre Toxicology · doi:10.1186/s12989-024-00579-5 · Cited by 36

Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology

Ashoub, M. H., Razavi, R., Heydaryan, K., Salavati‐Niasari, M., & Amiri, M. (2024) · European journal of medical research · doi:10.1186/s40001-024-01822-7 · Cited by 37

Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers

Cao, P. H. A., Dominic, A., Lujan, F. E., Senthilkumar, S., Bhattacharya, P. K., Frigo, D. E., & Subramani, E. (2024) · Nature Reviews Urology · doi:10.1038/s41585-024-00869-9 · Cited by 43

The involvement of ROS-regulated programmed cell death in hepatocellular carcinoma

Cai, H., Meng, Z., & Yu, F. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104361 · Cited by 37

An update on the role of ferroptosis in the pathogenesis of osteoporosis

Wu, X., Fang, X., Lu, F., Chen, Q., Liu, J., & Zheng, L. (2024) · EFORT Open Reviews · doi:10.1530/eor-23-0148 · Cited by 37

Peroxisomal homeostasis in metabolic diseases and its implication in ferroptosis

Han, J., Zheng, D., Liu, P.-S., Wang, S., & Xie, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01862-w · Cited by 37

Novel insights into the role of ferroptosis in temporomandibular joint osteoarthritis and knee osteoarthritis

Zhang, Y., Zhang, D., Liao, X., Xu, Q., Bu, L., Zheng, J., Shen, P., & Yang, C. (2025) · International Journal of Medical Sciences · doi:10.7150/ijms.107057 · Cited by 40

AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy

Hong, J. W., Xu, H., Yu, L., Zhuang, Y., Chen, X., Meng, Z., Zhu, J., Li, J., & Zhu, M. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01587-4 · Cited by 36

DUSP1 Blocks autophagy-dependent ferroptosis in pancreatic cancer

Xie, Y., Kuang, F., Liu, J., Tang, D., & Kang, R. (2020) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000054 · Cited by 36

Ferroptosis Is a Potential Novel Diagnostic and Therapeutic Target for Patients With Cardiomyopathy

Zhai, Z., Zou, P., Liu, F., Xia, Z., & Li, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.649045 · Cited by 38

The potential application of nanomaterials for ferroptosis-based cancer therapy

Li, Y., Wei, X., Feng, T., Deng, C., Lv, C., Chen, C., & Cheng, Y. (2021) · Biomedical Materials · doi:10.1088/1748-605x/ac058a · Cited by 36

Emerging roles of ferroptosis in infectious diseases

Bagayoko, S., & Meunier, É. (2021) · FEBS Journal · doi:10.1111/febs.16244 · Cited by 36

PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ

Wang, F., Graham, E. T., Naowarojna, N., Shi, Z., Wang, Y., Xie, G., Zhou, L., Salmon, W. C., Jia, J., Wang, X., et al. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.11.001 · Cited by 35

Ferroptosis Involvement in Glioblastoma Treatment

Mitre, A. O., Florian, I. A., Buruiană, A., Boer, A., Moldovan, I. M., Şoriţău, O., Florian, I. Ş., & Șușman, S. (2022) · Medicina · doi:10.3390/medicina58020319 · Cited by 39

Ferroptosis in hematological malignancies and its potential network with abnormal tumor metabolism

Zhang, J., Liu, Y., Li, Q., Xu, A., Hu, Y., & Sun, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112747 · Cited by 36

Role of Ferroptosis in Fibrotic Diseases

Zhou, J., Tan, Y., Wang, R., & Li, X. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s358470 · Cited by 36

Targeting the Macrophage-Ferroptosis Crosstalk: A Novel Insight into Tumor Immunotherapy

Zhou, Z., Xu, B., Hu, N., Guo, Z., Bao, W., Shao, B., & Yang, W. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2707203 · Cited by 37

The Relationship Between Ferroptosis and Diseases

Lv, J., Hou, B., Song, J., Xu, Y., & Xie, S. (2022) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s382643 · Cited by 36

Ferroptosis in aquaculture research

Xia, X., Cheng, Z., He, B., Liu, H., Liu, M., Hu, J., Lei, L., Wang, L., & Bai, Y. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736760 · Cited by 35

The Interplay Between Autophagy and Regulated Necrosis

Zhang, L., Cui, T., & Wang, X. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0110 · Cited by 39

Mechanisms of Ferritinophagy and Ferroptosis in Diseases

Li, S., Huang, P., Lai, F., Zhang, T., Guan, J., Wan, H., & He, Y. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03640-0 · Cited by 36

Cell Membrane‐Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis‐Enhanced Photodynamic Immunotherapy

Chen, J., Duan, Z., Deng, L., Li, L., Li, Q., Qu, J., Li, X., & Liu, R. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304436 · Cited by 35

Emerging regulatory mechanisms in cardiovascular disease: Ferroptosis

Jin, S., Wang, H., Zhang, X., Song, M., Liu, B., & Sun, W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116457 · Cited by 35

Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila

Davidson, A. J., Heron, R., Das, J., Overholtzer, M., & Wood, W. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01450-7 · Cited by 41

The role of cGAS-STING signaling pathway in ferroptosis

Ding, L., Zhang, R., Du, W., Wang, Q., & Pei, D. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.12.028 · Cited by 39

Reaction-Based Color-Convertible Fluorescent Probe for Ferroptosis Identification

Shi, L., Guan, Q., Gao, X., Jin, X., Xu, L., Shen, J., Wu, C., Zhu, X., & Zhang, C. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b01721 · Cited by 36

Global Characteristics and Trends in Research on Ferroptosis: A Data‐Driven Bibliometric Study

Dong, X., Tan, Y., Zhuang, D., Hu, T., & Zhao, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8661864 · Cited by 35

Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases

Lan, T., Sun, T., Wei, C., Cheng, T., Yang, F., Zhang, J.-N., & Li, Q. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03267-1 · Cited by 35

Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome

Wang, G., Yin, W., Shin, H., Tian, Q., Lü, W., & Hou, X. S. (2021) · Nature Aging · doi:10.1038/s43587-021-00130-7 · Cited by 40

GPX4 at the crossroads of lipid homeostasis and ferroptosis

Forcina, G. C., & Dixon, S. J. (2019) · PROTEOMICS · doi:10.1002/pmic.201800311 · Cited by 1,025

Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death

Самович, С. Н., Mikulska‐Ruminska, K., Dar, H. H., Tyurina, Y. Y., Tyurin, V. A., Souryavong, A. B., Kapralov, A. A., Amoscato, A. A., Beharier, O., Karumanchi, S. A., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202314710 · Cited by 1

Tocopherols and tocotrienols prevent lipoxygenase‐driven phospholipid oxidation in ferroptosis

Mao, G., Qu, F., Angeli, J. P. F., Croix, C. M. S., Dar, H. H., Tyurin, V. A., Ritov, V. B., Kapralov, A. A., Amoscato, A. A., Anthonymuthu, T. S., et al. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.946.3

PKCβII–ACSL4 pathway mediating ferroptosis execution and anti‐tumor immunity

Lei, G., Horbath, A. D., Zhuang, L., & Gan, B. (2022) · 癌症：英文版 · doi:10.1002/cac2.12319 · Cited by 40

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

Ursini, F., & Maiorino, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.027 · Cited by 1,954