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Ferroptosis as a p53-mediated activity during tumour suppression

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The Role of Ferroptosis in Cancer Development and Treatment Response

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Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis

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Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

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The chemistry and biology of ferroptosis

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Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

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Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

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ROS induced lipid peroxidation and their role in ferroptosis

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Identification of essential sites of lipid peroxidation in ferroptosis

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The application of Ferroptosis in diseases

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Molecular mechanisms of ferroptosis and their involvement in brain diseases

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Organelle-specific regulation of ferroptosis

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Tumour fatty acid metabolism in the context of therapy resistance and obesity

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Regulatory Phenomena in the Glutathione Peroxidase Superfamily

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Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

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Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

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Ferroptosis and necroinflammation, a yet poorly explored link

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Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism

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Lipid Metabolism and Ferroptosis

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7-Dehydrocholesterol dictates ferroptosis sensitivity

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Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells

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Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

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Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration

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Ferroptosis in Cancer Cell Biology

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Repression of the antiporter SLC7A11/glutathione/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification

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Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure

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The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

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Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis

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Ferroptosis in health and disease

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The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

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Lipid Peroxidation and Antioxidant Protection

Valgimigli, L. (2023) · Biomolecules · doi:10.3390/biom13091291 · Cited by 393

Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications

Zheng, Y., Sun, J., Luo, Z., Li, Y., & Huang, Y. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07244-x · Cited by 378

Cell death pathways: intricate connections and disease implications

Kist, M., & Vucic, D. (2021) · The EMBO Journal · doi:10.15252/embj.2020106700 · Cited by 337

Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis

Mortensen, M. S., Ruiz, J., & Watts, J. L. (2023) · Cells · doi:10.3390/cells12050804 · Cited by 346

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

He, Y., Liu, X., Xing, L., Wan, X., Chang, X. Y., & Jiang, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119911 · Cited by 323

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

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Emerging mechanisms and targeted therapy of ferroptosis in cancer

Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J. X., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 326

Ferroptosis: bug or feature?

Dixon, S. J. (2017) · Immunological Reviews · doi:10.1111/imr.12533 · Cited by 314

Ferroptosis Detection: From Approaches to Applications

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Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer

Ghoochani, A., Hsu, E., Aslan, M., Rice, M. A., Nguyen, H. M., Brooks, J. D., Corey, E., Paulmurugan, R., & Stoyanova, T. I. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3477 · Cited by 324

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury*

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The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis

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Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

Ashraf, A., Jeandriens, J., Parkes, H. G., & So, P. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101494 · Cited by 306

Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO 3 nanoformulation triggers ferroptosis in target tumor cells

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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

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Ferroptosis: principles and significance in health and disease

Chen, F., Kang, R., Tang, D., & Liu, J. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01564-3 · Cited by 341

A guideline on the molecular ecosystem regulating ferroptosis

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Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease

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FSP1: a key regulator of ferroptosis

Li, W., Liang, L., Liu, S., Yi, H., & Zhou, Y. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.05.013 · Cited by 296

NUPR1 is a critical repressor of ferroptosis

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Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

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ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

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Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

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Ferroptosis in liver disease: new insights into disease mechanisms

Wu, J., Wang, Y., Jiang, R., Xue, R., Yin, X., Wu, M., & Meng, Q. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00660-4 · Cited by 291

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

Lane, D. J. R., Ayton, S., & Bush, A. I. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179944 · Cited by 287

Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke

Mao, R., Zong, N., Hu, Y., Chen, Y., & Xu, Y. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00859-0 · Cited by 296

Ferroptosis and Necroptosis in the Kidney

Belavgeni, A., Meyer, C., Stumpf, J., Hugo, C., & Linkermann, A. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.016 · Cited by 286

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

Lewerenz, J., Ates, G., Methner, A., Conrad, M., & Maher, P. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00214 · Cited by 276

Ferroptosis and Its Potential Role in Human Diseases

Han, C., Liu, Y., Dai, R., Ismail, N., Su, W., & Li, B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00239 · Cited by 283

Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1

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Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus

Sha, W., Hu, F., Yang, X., Chu, Y., & Bu, S. (2021) · Journal of Diabetes Research · doi:10.1155/2021/9999612 · Cited by 276

Heat stress induces ferroptosis-like cell death in plants

Distéfano, A. M., Martin, M. V., Córdoba, J. P., Bellido, A. M., D’Ippólito, S., Colman, S. L., Soto, D., Roldán, J. A., Bartoli, C. G., Zabaleta, E. J., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201605110 · Cited by 268

Molecular mechanisms of ferroptosis and relevance to inflammation

Deng, L., He, S., Guo, N., Tian, W., Zhang, W., & Luo, L. (2022) · Inflammation Research · doi:10.1007/s00011-022-01672-1 · Cited by 273

Ferroptosis: when metabolism meets cell death

Zheng, J., & Conrad, M. (2024) · Physiological Reviews · doi:10.1152/physrev.00031.2024 · Cited by 286

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

Beatty, A., Singh, T., Tyurina, Y. Y., Tyurin, V. A., Samovich, S., Nicolas, E., Maslar, K., Zhou, Y., Cai, K. Q., Tan, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22471-y · Cited by 268

The emerging role of ferroptosis in intestinal disease

Xu, S., He, Y., Lin, L., Chen, P., Chen, M., & Zhang, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03559-1 · Cited by 265

ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4

Wu, H., Liu, Q., Shan, X., Gao, W., & Chen, Q. (2023) · Autophagy · doi:10.1080/15548627.2023.2170960 · Cited by 267

Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis

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Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

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The pathological role of ferroptosis in ischemia/reperfusion-related injury

Yan, H.-F., Tuo, Q., Yin, Q., & Lei, P. (2020) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2020.042 · Cited by 251

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases

Johnson, J., Mercado‐Ayón, E., Mercado-Ayon, Y., Dong, Y., Halawani, S. M., Ngaba, L. V., & Lynch, D. R. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108698 · Cited by 254

Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2/HO-1 signaling pathway

Chen, Y., Zhang, P., Chen, W., & Chen, G. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.06.005 · Cited by 247

Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

Zhang, S., Xin, W., Anderson, G. J., Li, R., Gao, L., Chen, S., Zhao, J., & Liu, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04490-1 · Cited by 250

Transcription factors in ferroptotic cell death

Dai, C., Chen, X., Li, J., Comish, P. B., Kang, R., & Tang, D. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0170-2 · Cited by 244

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis

Cui, W., Liu, D., Gu, W. J., & Chu, B. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00769-0 · Cited by 242

AIFM2 blocks ferroptosis independent of ubiquinol metabolism

Dai, E., Zhang, W., Cong, D., Kang, R., Wang, J., & Tang, D. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.066 · Cited by 238

Adipocyte‐Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer

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Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells

Perez, M. A., Magtanong, L., Dixon, S. J., & Watts, J. L. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.019 · Cited by 226

Ironing out the role of ferroptosis in immunity

Bell, H. N., Stockwell, B. R., & Zou, W. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.019 · Cited by 238

An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis

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