Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions
Open accessAbstract
Radiotherapy is applied in about 70% patients with tumors, yet radioresistance of tumor cells remains a challenge that limits the efficacy of radiotherapy. Ferroptosis, an iron-dependent lipid peroxidation regulated cell death, is involved in the development of a variety of tumors. Interestingly, there is evidence that ferroptosis inducers in tumor treatment can significantly improve radiotherapy sensitivity. In addition, related studies show that Glutathione S-transferase P1 (GSTP1) is closely related to the development of ferroptosis. The potential mechanism of targeting GSTP1 to inhibit tumor cells from evading ferroptosis leading to radioresistance has been proposed in this review, which implies that GSTP1 may play a key role in radiosensitization of lung cancer via ferroptosis pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some GST family members have been shown to inhibit ferroptosis in lung, pancreatic, and gastric cancers.
“Some GST family members have been shown to inhibit ferroptosis in lung, pancreatic, and gastric cancers (57–59).”
From The origin of hepatocellular carcinoma depends on metabolic zonation (2026) · cites this paper as [57]
The Perspective (page unavailable) reports that GSTM1 inhibits ferroptosis in brain metastases from lung cancer. It presents GSTP1’s role in lung cancer as a hypothesis, however, and the passages addressing pancreatic and gastric cancer do not establish GST-mediated inhibition of ferroptosis in either. Thus the source supports the lung-cancer portion, but not the full three-cancer claim. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Rehman, M. U., Rashid, S., Arafah, A. M., Qamar, W., Alsaffar, R. M., Ahmad, A., Almatroudi, N. M., Alqahtani, S. M. A., Rashid, S. M., & Ahmad, S. B. (2020) · Biology · doi:10.3390/biology9090302 · Cited by 52 · see citing works
RetractedSung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699 · see citing works
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works
Ferroptosis: mechanisms, biology and role in disease
Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,720 · see citing works
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695 · see citing works
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works
Ferroptosis: past, present and future
Li, J., Cao, F., Yin, H.-L., Huang, Z.-J., Lin, Z.-T., Mao, N., Sun, B., & Wang, G. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2298-2 · Cited by 4,171 · see citing works
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732 · see citing works
Hayes, J. D., & Pulford, D. J. (1995) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239509083491 · Cited by 3,471 · see citing works
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
Stockwell, B. R. (2022) · Cell · doi:10.1016/j.cell.2022.06.003 · Cited by 3,135 · see citing works
Cancer and Radiation Therapy: Current Advances and Future Directions
Baskar, R., Lee, K. A., Yeo, R., & Yeoh, K. (2012) · International Journal of Medical Sciences · doi:10.7150/ijms.3635 · Cited by 2,927 · see citing works
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
Yang, W. S., Kim, K. J., Gaschler, M. M., Patel, M., Shchepinov, M. S., & Stockwell, B. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603244113 · Cited by 2,329 · see citing works
Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
Azzam, E. I., Jay‐Gerin, J., & Pain, D. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.12.012 · Cited by 1,611 · see citing works
The Metabolic Underpinnings of Ferroptosis
Zheng, J., & Conrad, M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.011 · Cited by 1,340 · see citing works
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
Lei, G., Zhang, Y., Koppula, P., Liu, X., Zhang, J., Lin, S. H., Ajani, J. A., Xiao, Q., Liao, Z., Wang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-019-0263-3 · Cited by 1,318 · see citing works
Emerging Mechanisms and Disease Relevance of Ferroptosis
Stockwell, B. R., Jiang, X., & Gu, W. J. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.02.009 · Cited by 1,108 · see citing works
Lang, X., Green, M. D., Wang, W., Yu, J., Choi, J. E., Jiang, L., Liao, P., Zhou, J., Zhang, Q., Dow, A., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0338 · Cited by 1,066 · see citing works
Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
Zou, Y., Henry, W. S., Ricq, E. L., Graham, E. T., Phadnis, V. V., Maretich, P., Paradkar, S., Boehnke, N., Deik, A., Reinhardt, F., et al. (2020) · Nature · doi:10.1038/s41586-020-2732-8 · Cited by 849 · see citing works
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Feng, H., & Stockwell, B. R. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006203 · Cited by 759 · see citing works
Ionizing Radiation-Induced DNA Damage, Response, and Repair
Santivasi, W. L., & Xia, F. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5668 · Cited by 603 · see citing works
An enzyme from rat liver catalysing conjugations with glutathione
Booth, J., Boyland, E. J., & Sims, P. H. (1961) · Biochemical Journal · doi:10.1042/bj0790516 · Cited by 576 · see citing works
Ferroptosis Inhibition: Mechanisms and Opportunities
Angeli, J. P. F., Shah, R., Pratt, D. A., & Conrad, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.02.005 · Cited by 563 · see citing works
Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death
Tesfay, L., Paul, B. T., Konstorum, A., Deng, Z., Cox, A. O., Lee, J., Furdui, C. M., Hegde, P., Torti, F. M., & Torti, S. V. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0369 · Cited by 554 · see citing works
Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers
Ye, L. F., Chaudhary, K. R., Zandkarimi, F., Harken, A. D., Kinslow, C. J., Upadhyayula, P. S., Dovas, A., Higgins, D. M. O., Tan, H., Zhang, Y., et al. (2020) · ACS Chemical Biology · doi:10.1021/acschembio.9b00939 · Cited by 527 · see citing works
Ferroptosis, radiotherapy, and combination therapeutic strategies
Lei, G., Mao, C., Yan, Y., Zhuang, L., & Gan, B. (2021) · Protein & Cell · doi:10.1007/s13238-021-00841-y · Cited by 519 · see citing works
Koppula, P., Lei, G., Zhang, Y., Yan, Y., Mao, C., Kondiparthi, L., Shi, J., Liu, X., Horbath, A. D., Das, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29905-1 · Cited by 478 · see citing works
Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3
Shintoku, R., Takigawa, Y., Yamada, K., Kubota, C., Yoshimoto, Y., Takeuchi, T., Koshiishi, I., & Torii, S. (2017) · Cancer Science · doi:10.1111/cas.13380 · Cited by 453 · see citing works
Masaldan, S., Clatworthy, S. A. S., Gamell, C., Meggyesy, P. M., Rigopoulos, A.-T., Haupt, S., Haupt, Y., Denoyer, D., Adlard, P. A., Bush, A. I., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2017.08.015 · Cited by 452 · see citing works
Shah, Y. M., Matsubara, T., Ito, S., Yim, S.-H., & Gonzalez, F. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.012 · Cited by 431 · see citing works
Contemporary radiotherapy: present and future
Chandra, R. A., Keane, F. K., Voncken, F. E. M., & Thomas, C. R. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00233-6 · Cited by 389 · see citing works
Jeong, Y., Hoang, N. T., Lovejoy, A. F., Stehr, H., Newman, A. M., Gentles, A. J., Kong, W. W., Truong, D., Martin, S. A., Chaudhuri, A. A., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0127 · Cited by 348 · see citing works
Tang, L., Zhou, Y.-J., Xiong, X.-M., Li, N., Zhang, J.-J., Luo, X., & Peng, J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.307 · Cited by 301 · see citing works
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
Zhang, W., Sun, Y., Bai, L., Zhi, L., Yang, Y., Zhao, Q., Chen, C., Qi, Y., Gao, W., He, W., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci152067 · Cited by 293 · see citing works
Feng, L., Zhao, K., Sun, L., Yin, X., Zhang, J., Liu, C., & Li, B. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03042-7 · Cited by 277 · see citing works
Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers
Buckley, A. M., Lynam‐Lennon, N., O’Neill, H., & O'Sullivan, J. N. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0247-2 · Cited by 255 · see citing works
Zhou, H., Zhou, Y., Mao, J.-A., Tang, L., Xu, J., Wang, Z., He, Y., & Li, M. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102413 · Cited by 234 · see citing works
The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer
Tew, K. D., Manevich, Y., Grek, C. L., Xiong, Y., Uys, J. D. K., & Townsend, D. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.013 · Cited by 233 · see citing works
HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
Singhal, R., Mitta, S. R., Das, N. K., Kerk, S. A., Sajjakulnukit, P., Solanki, S., Andren, A., Kumar, R., Olive, K. P., Banerjee, R., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143691 · Cited by 215 · see citing works
The multifaceted role of glutathione S-transferases in cancer
Chatterjee, A., & Gupta, S. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.06.028 · Cited by 215 · see citing works
Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish
Umamaheswari, S., Priyadarshinee, S., Kadirvelu, K., & Ramesh, M. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109550 · Cited by 210 · see citing works
Radioprotective agents to prevent cellular damage due to ionizing radiation
Smith, T. A., Kirkpatrick, D. R., Smith, S., Smith, T. K., Pearson, T., Kailasam, A., Herrmann, K. Z., Schubert, J., & Agrawal, D. K. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1338-x · Cited by 209 · see citing works
Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11
Dong, H., Xia, Y., Jin, S., Xue, C., Wang, Y., Hu, R., & Jiang, H. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04307-1 · Cited by 196 · see citing works
Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer
Zhang, Z., Lu, M., Chen, C., Tong, X., Li, Y., Yang, K., Lv, H., Xu, J., & Qin, L. (2021) · Theranostics · doi:10.7150/thno.52028 · Cited by 194 · see citing works
Mukha, A., Kahya, U., Linge, A., Chen, O., Löck, S., Lukiyanchuk, V., Richter, S., Alves, T. C., Peitzsch, M., Telychko, V., et al. (2021) · Theranostics · doi:10.7150/thno.58655 · Cited by 183 · see citing works
Pouget, J., Georgakilas, A. G., & Ravanat, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7267 · Cited by 160 · see citing works
Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin
Tang, Z., Jiang, W., Mao, M., Zhao, J., Chen, J., & Cheng, N. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.390 · Cited by 160 · see citing works
Shibata, Y., Yasui, H., Higashikawa, K., Miyamoto, N., & Kuge, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225931 · Cited by 145 · see citing works
The structure of the human glutathione S-transferase π gene
Cowell, I. G., DIXON, K. H., Pemble, S. E., KETTERER, B., & Taylor, J. B. (1988) · Biochemical Journal · doi:10.1042/bj2550079 · Cited by 129 · see citing works
Ali‐Osman, F., Brunner, J. M., Kutluk, T. M., & Hess, K. (1997) · PubMed · Cited by 123 · see citing works
GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review)
Cui, J., Li, G., Yin, J., Li, L., Tan, Y., Wei, H., Liu, B., Deng, L., Tang, J., Chen, Y., et al. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.4979 · Cited by 122 · see citing works
Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer
Lee, J., You, J. H., & Roh, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102276 · Cited by 118 · see citing works
Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4‑mediated ferroptosis
Pan, X., Lin, Z., Jiang, D., Yu, Y., Yang, D., Zhou, H., Zhan, D., Liu, S., Peng, G., Chen, Z., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.9888 · Cited by 115 · see citing works
Glutathione S-transferases in kidney and urinary bladder tumors
Simic, T. P., Savic-Radojevic, A. R., Pljesa-Ercegovac, M. S., Matic, M. G., & Mimić-Oka, J. (2009) · Nature Reviews Urology · doi:10.1038/nrurol.2009.49 · Cited by 112 · see citing works
Sitthideatphaiboon, P., Galán‐Cobo, A., Negrao, M. V., Qu, X. H., Poteete, A., Zhang, F., Liu, D. D., Lewis, W. E., Kemp, H. N., Lewis, J., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-2859 · Cited by 112 · see citing works
Takashi, Y., Tomita, K., Kuwahara, Y., Roudkenar, M. H., Roushandeh, A. M., Igarashi, K., Nagasawa, T., Nishitani, Y., & Sato, T. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.09.027 · Cited by 104 · see citing works
Liu, J., Huang, C., Liu, J., Meng, C., Gu, Q., Du, X., Yan, M., Yu, Y., Liu, F., & Xia, C. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106563 · Cited by 104 · see citing works
Liu, W., Zhou, Y., Duan, W., Song, J., Wei, S., Xia, S., Wang, Y., Du, X., Li, E., Ren, C., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.517 · Cited by 96 · see citing works
Ikeda, H., Serria, M. S., Kakizaki, I., Hatayama, I., Satoh, K., Tsuchida, S., Muramatsu, M., Nishi, S., & Sakai, M. (2002) · Biochemical Journal · doi:10.1042/bj20011756 · Cited by 93 · see citing works
Holley, S. L., Fryer, A. A., Haycock, J. W., Grubb, S. E. W., Strange, R. C., & Hoban, P. R. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm135 · Cited by 88 · see citing works
Tomita, K., Fukumoto, M., Itoh, K., Kuwahara, Y., Igarashi, K., Nagasawa, T., Suzuki, M., Kurimasa, A., & Sato, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.117 · Cited by 86 · see citing works
Bartolini, D., Commodi, J., Piroddi, M., Incipini, L., Sancineto, L., Santi, C., & Galli, F. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.039 · Cited by 85 · see citing works
Broken hearts: Iron overload, ferroptosis and cardiomyopathy
Conrad, M., & Proneth, B. (2019) · Cell Research · doi:10.1038/s41422-019-0150-y · Cited by 84 · see citing works
Zhao, Y., Lü, J., Mao, A., Zhang, R., & Guan, S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c03751 · Cited by 81 · see citing works
S‐Glutathionylation of Keap1: a new role for glutathioneS‐transferase pi in neuronal protection
Carvalho, A. N., Marques, C., Guedes, R. C., Castro‐Caldas, M., Rodrigues, E., van Horssen, J., & Gama, M. J. (2016) · FEBS Letters · doi:10.1002/1873-3468.12177 · Cited by 80 · see citing works
Ritchie, K. J., Henderson, C. J., Wang, X. J., Vassieva, O., Carrie, D., Farmer, P. B., Gaskell, M., Park, K., & Wolf, C. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1764 · Cited by 78 · see citing works
Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis
Fang, Y., Ye, J., Zhao, B., Sun, J., Na, G., Chen, X., Ren, L., Chen, J., Cai, X., Zhang, W., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101677 · Cited by 78 · see citing works
Iron, oxidative stress and the example of solar ultraviolet a radiation.
Aroun, A., Zhong, J. L., Tyrrell, R. M., & Pourzand, C. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05204g · Cited by 74 · see citing works
xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction
Cobler, L., Zhang, H., Suri, P., Park, C., & Timmerman, L. (2018) · Oncotarget · doi:10.18632/oncotarget.25794 · Cited by 72 · see citing works
Busato, F., Khouzai, B. E., & Mognato, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810211 · Cited by 72 · see citing works
Awasthi, S., Ramana, K. V., Chaudhary, P., Sk, S., & Awasthi, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.493 · Cited by 66 · see citing works
Mian, O. Y., Khattab, M. H., Hedayati, M. A., Coulter, J. B., Abubaker‐Sharif, B., Schwaninger, J. M., Veeraswamy, R. K., Brooks, J. D., Hopkins, L., Shinohara, D. B., et al. (2015) · The Prostate · doi:10.1002/pros.23111 · Cited by 62 · see citing works
Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence
Sukiennicki, G., Marciniak, W., Muszyńska, M., Baszuk, P., Gupta, S., Białkowska, K., Jaworska–Bieniek, K., Durda, K., Lener, M. R., Pietrzak, S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0208610 · Cited by 62 · see citing works
Thermozier, S., Hou, W., Zhang, X., Shields, D. S., Fisher, R., Bayır, H., Kagan, V. E., Yu, J., Liu, B., Bahar, İ., et al. (2020) · Radiation Research · doi:10.1667/rr15486.1 · Cited by 61 · see citing works
van de Wetering, C., Elko, E. A., Berg, M., Schiffers, C., Stylianidis, V., van den Berge, M., Nawijn, M. C., Wouters, E. F. �., Janssen-Heininger, Y. M. W., & Reynaert, N. L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101995 · Cited by 59 · see citing works
Peng, J., Pan, J., Mo, J., & Peng, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8217663 · Cited by 58 · see citing works
Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma
Lei, K., Gu, X., Alvarado, A. G., Du, Y., Luo, S., Ahn, E. H., Kang, S. S., Ji, B., Liu, X., Mao, H. Z., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00979-y · Cited by 58 · see citing works
Targeting lipid metabolism for ferroptotic cancer therapy
Luo, M., Yan, J., Hu, X., Li, H., Li, H., Liu, Q., Chen, Y., & Zou, Z. (2022) · APOPTOSIS · doi:10.1007/s10495-022-01795-0 · Cited by 57 · see citing works
Morceau, F., Duvoix, A., Delhalle, S., Schnekenburger, M., Dicato, M. A., & Diederich, M. F. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.10.036 · Cited by 50 · see citing works
Role of HGF/MET axis in resistance of lung cancer to contemporary management.
Raghav, K. P. S., Gonzalez-Angulo, A. M., & Blumenschein, G. R. (2012) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2012.09.04 · Cited by 49 · see citing works
Bănescu, C. V., Trifa, A. P., Voidăzan, S. T., Moldovan, V. G., Macarie, I., Lázár, E., Dima, D. M., Duicu, C., & Dobreanu, M. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/875861 · Cited by 48 · see citing works
Savic-Radojevic, A. R., Mimić-Oka, J., Pljesa-Ercegovac, M. S., Opacic, M., Dragicevic, D. P., Kravic‐Stevovic, T., Djokic, M., Mičić, S., & Simic, T. P. (2007) · European Urology · doi:10.1016/j.eururo.2007.01.046 · Cited by 44 · see citing works
Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment
Wu, M., Ling, W., Wei, J., Liao, R., Sun, H., Li, D., Zhao, Y., & Zhao, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.026 · Cited by 43 · see citing works
FBX8 degrades GSTP1 through ubiquitination to suppress colorectal cancer progression
FeiFei, W., Xu, H., YongRong, Y., Wu, P., Wu, J., XiaoHui, Z., Li, J., Sun, J., Kun, Z., Xiao-li, R., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1588-z · Cited by 37 · see citing works
Bader, S., Wilmers, J., Pelzer, M., Jendrossek, V., & Rudner, J. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.024 · Cited by 35 · see citing works
Duvoix, A., Schnekenburger, M., Delhalle, S., Blasius, R., Borde-Chiché, P., Morceau, F., Dicato, M. A., & Diederich, M. F. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.05.004 · Cited by 35 · see citing works
Gao, Y., Chen, B., Wang, R., Xu, A., Wu, L., Lü, H., & Zhao, G. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01140-z · Cited by 33 · see citing works
GSTP1 as a novel target in radiation induced lung injury
Lei, X., Du, L., Wei, Y., Wang, Y., Ma, N., & Qu, B. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02978-0 · Cited by 32 · see citing works
Self-citationИванов, С. Д., Семенов, А. Л., Eg, K., & Yamshanov, V. A. (2015) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-015-2865-1 · Cited by 30 · see citing works
Ward, H. A., Whitman, J., Muller, D. C., Johansson, M., Jakszyn, P. G., Weiderpass, E., Palli, D., Fanidi, A., Vermeulen, R. C. H., Tjønneland, A. M., et al. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0271-2 · Cited by 28 · see citing works
Pljesa-Ercegovac, M. S., Savic-Radojevic, A. R., Dragicevic, D. P., Mimić-Oka, J., Matic, M. G., Sašić, T., Pekmezovic, T. D., Vuksanović, A., & Simic, T. P. (2009) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2008.10.019 · Cited by 28 · see citing works
Fujikawa, Y., Nampo, T., Mori, M., Kikkawa, M., & Inoue, H. (2017) · Talanta · doi:10.1016/j.talanta.2017.12.010 · Cited by 26 · see citing works
Re, A., Aiello, A., Nanni, S., Grasselli, A., Benvenuti, V., Pantisano, V., Strigari, L., Colussi, C., Ciccone, S., Mazzetti, A. P., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-1024 · Cited by 23 · see citing works
Pajaud, J., Ribault, C., Mosbah, I. B., Rauch, C., Henderson, C. J., Bellaud, P., Aninat, C., Loyer, P., Morel, F., & Corlu, A. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.562 · Cited by 21 · see citing works
Эффекты дополнительного введения ионов железа при лучевой терапии животных-опухоленосителей
Иванов, С. Д., Семёнов, А. Л., Mikhelson, V. M., Eg, K., & Ямшанов, В. А. (2013) · Радиационная биология Радиоэкология · doi:10.7868/s0869803113030065 · Cited by 12 · see citing works
Yang, M., Wu, D., Sun, H., Wang, L., & Chen, X. (2022) · Brain Sciences · doi:10.3390/brainsci12091138 · Cited by 9 · see citing works
Chemoprevention of pancreatic cancer by inhibition of glutathione-S transferase P1
Kogawa, T., Sato, Y., Shimoyama, R., Kurata, W., Tashiro, Y., & Niitsu, Y. (2021) · Investigational New Drugs · doi:10.1007/s10637-021-01129-y · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zinc and its binding proteins: essential roles and therapeutic potential
Kiouri, D. P., Chasapis, C. T., Mavromoustakos, T., Spiliopoulou, C., & Stefanidou, M. E. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03891-3 · Cited by 56 · see citing works
The Regulation of Ferroptosis by Noncoding RNAs
Zheng, X., & Zhang, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713336 · Cited by 42 · see citing works
Shu, G., Chen, K., Li, J., Liu, B. Y., Chen, X., Wang, J., Hu, X., Lu, W., Huang, H., & Zhang, S. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155989 · Cited by 40 · see citing works
Research progress and insights on the role of ferroptosis in wound healing
Bi, M., Li, D., & Zhang, J. (2023) · International Wound Journal · doi:10.1111/iwj.14102 · Cited by 34 · see citing works
Cuproptosis: a novel therapeutic mechanism in lung cancer
Luo, C., Wu, X., Zhang, S., Tan, J., Huo, Y., Zhang, X., Ning, B., Ye, Y., & Wang, F. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03864-1 · Cited by 27 · see citing works
Duan, W.-L., Ma, Y., Wang, X.-J., Ma, C., Han, B., Sheng, Z.-M., Dong, H., Zhang, L., Li, P. A., Zhang, B., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176553 · Cited by 25 · see citing works
The origin of hepatocellular carcinoma depends on metabolic zonation
Guo, J., Liang, R., Chung, A., Li, Z., Li, B., Chen, E., Li, L., Wang, J., Hsieh, M.-H., Fang, I. X., et al. (2026) · Science · doi:10.1126/science.adv7129 · Cited by 24 · see citing works
MMP9 drives ferroptosis by regulating GPX4 and iron signaling
Gawargi, F. I., & Mishra, P. K. (2024) · iScience · doi:10.1016/j.isci.2024.110622 · Cited by 23 · see citing works
Ye, C., Xu, J., Shi, L., Zong, C., Ji, W., Lu, Y., Tao, R., Han, F., & Ma, H. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123532 · Cited by 20 · see citing works
Zhou, S. M., Ou, H., Wu, Y., Qi, D., Pei, X., Yu, X., Hu, X., & Wu, E. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108434 · Cited by 20 · see citing works
Iron and energy metabolic interactions in Treg-mediated immune regulation
Savagner, F., Farge, T., Karim, Z., & Aloulou, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1554028 · Cited by 10 · see citing works
Nanomaterial-mediated ferroptosis as a promising strategy for cancer therapy
Tang, Y., Zhou, Q., Fan, Y., Liu, T., Zhu, L., & Liu, M. (2025) · Nanoscale · doi:10.1039/d5nr03627e · Cited by 10 · see citing works
Zhu, Y., Chen, Y., Wang, Y., Zhu, Y., Wang, H., Zuo, M., Wang, J., Li, Y., & Chen, X.-L. (2024) · The FASEB Journal · doi:10.1096/fj.202400373rr · Cited by 11 · see citing works
Unraveling the Molecular Regulation of Ferroptosis in Respiratory Diseases
Zhu, L., Zhou, J., Yu, C., Gu, L., Wang, Q., Xu, H., Zhu, Y., Guo, M., Hu, M., Peng, W., et al. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s457092 · Cited by 9 · see citing works
GSTP1 inhibits angiotensin II-induced atrial fibrillation by regulating ferroptosis
Han, L., Feng, Z., Benke, L., Bai, J., Lin, Q., Yu, X., Zhang, N., Xie, Y., & Yang, X. (2025) · EP Europace · doi:10.1093/europace/euaf083 · Cited by 8 · see citing works
Relationship between hepatic lipid accumulation and type 2 diabetes mellitus
Wang, Z., Zan, W., Fan, Z., & Wang, S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118723 · Cited by 8 · see citing works
Wang, H., Yang, F., Wu, Y., Zhang, Z., & Zhang, C. (2025) · Genes & Genomics · doi:10.1007/s13258-025-01669-0 · Cited by 6 · see citing works
Involvement of GSTP1 in low dose radiation-induced apoptosis in GM12878 cells
Cui, J., Li, L., Wei, S., Wei, Y., Gong, Y., Yan, H., Yu, Y., Lin, X., Qin, H., Li, G., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116128 · Cited by 6 · see citing works
Li, S., Yang, L., & Li, J. (2024) · Medicine · doi:10.1097/md.0000000000038606 · Cited by 4 · see citing works
Non-coding RNAs as master regulators of ferroptosis in cancer: mechanisms and clinical implications
Mo, H., Xie, Y., Zhang, H. Z. H., Liu, Y., Wu, W., Xia, Z., Luo, P., Liu, Z., & Cheng, Q. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02666-x · Cited by 3 · see citing works
Wang, G., Cao, Y., Hu, T., Cai, Z., Chen, C., Geng, Q., Luo, X., Yang, L., Wang, W., Jin, J., et al. (2025) · Cancer Science · doi:10.1111/cas.70019 · Cited by 3 · see citing works
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Genes and Environment · doi:10.1186/s41021-024-00310-y · Cited by 2 · see citing works
Duttenhefner, J. N., Singh, R. R., Schmidt, K., & Reindl, K. M. (2025) · Biology Open · doi:10.1242/bio.061986 · Cited by 2 · see citing works
Li, Q., Shen, L., Yang, Y., Tai, G., Zhu, Q., Liu, C., Ge, Q., & Yi, Q. (2025) · Journal of Cancer · doi:10.7150/jca.113046 · Cited by 1 · see citing works
The intersection of ferroptosis and non-coding RNAs: a novel approach to lung cancer
Ding, J. (2025) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-025-04099-9 · Cited by 1 · see citing works
GSTM3 alleviates FLASH X-ray-induced testicular injury by modulating the ferroptosis pathway
Zhi, X., Du, L., Huang, X., Liu, F., Ma, N., Guo, X., Wang, Y., He, Q., Yu, W., Dai, X., et al. (2026) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2026.111667 · Cited by 1 · see citing works
Self-citationEnhancement of Breast Cancer Chemotherapy and Radiotherapy Responses by Modulation of Ferroptosis
Al-Zufairi, A. A. M. (2024) · Sheffield Hallam University · doi:10.7190/shu-thesis-00623
Jovanović, M., & Šeklić, D. (2025) · doi:10.3390/proceedings2025119003
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746928
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746913
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746919
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746910
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746934
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746925
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746916
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746931
Abu-Bakar, A., Ismail, M., Zulkifli, M. Z. I., Zaini, N. A. S., Shukor, N. I. A., Harun, S., & Inayat‐Hussain, S. H. (2024) · Figshare · doi:10.6084/m9.figshare.26746922
The expanding functional landscape of GSTP1 in cancer beyond detoxification
Chen, W., Jiang, Y., & Xiao, Z.-J. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105568
Dai, L., Tan, J., Zhou, Z., Chen, C., Hu, G., & Guo, L. (2026) · PLoS ONE · doi:10.1371/journal.pone.0356638
Sang, S., Lv, G., Feng, S., Zhao, H., Ren, Y., Jin, D., & Wang, K. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1886712
- Authors
- Tan, X., Huang, X., Niu, B., Guo, X., Lei, X., & Qu, B.
- Affiliations
- Chinese PLA General Hospital (CN)
- Corresponding author
- Lei, Xiao
- Qu, Baolin
- Venue
- Frontiers in Molecular Biosciences
- Publisher
- Frontiers Media SA
- Published
- 2022-12-16
- Volume
- 9
- Pages
- 1102158-1102158
- ISSN
- 2296-889X (ISSN-L)
- PMC
- PMC9800622
- OpenAlex
- W4313271750
- Cited by
- 40
- References
- 97
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 19 · 2023: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Molecular Biosciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (20BJZ40 82003387)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- ferroptosis, GSTP1, glutathione S-transferase pi, lung cancer, radiotherapy, radioresistance (biology), radiosensitization, lipid peroxidation, iron-dependent cell death, ferroptosis inducers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
