The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
Open accessAbstract
Significance: Cytotoxic T lymphocyte antigen-4 (CTLA-4), up-regulated by activated conventional T cells and constitutively expressed by Foxp3+regulatory T cells, is essential for immunological self-tolerance. Because of early fatality in germ-line CTLA-4–deficient mice, the role in adulthood remains unclear. We abrogated CTLA-4 expression in adult mice and compared their phenotype with congenitally CTLA-4–deleted mice. We found that the two modes of CTLA-4 deficiency differed in resulting autoimmune disease phenotype and severity. Additionally, although CTLA-4–deficient mice had more severe collagen-induced arthritis, they were protected against peptide-induced experimental autoimmune encephalomyelitis (EAE). However, onset of protein-induced EAE was only delayed. These results taken together indicate that CTLA-4 deficiency affects both central and peripheral tolerance and Treg cell-mediated suppression.
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Cites
Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar
Miller, G. L. (1959) · Analytical Chemistry · doi:10.1021/ac60147a030 · Cited by 28,963
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H., & Mak, T. W. (1995) · Science · doi:10.1126/science.270.5238.985 · Cited by 2,766
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
Qureshi, O. S., Zheng, Y., Nakamura, K., Attridge, K., Manzotti, C., Schmidt, E. M., Baker, J., Jeffery, L. E., Kaur, S., Briggs, Z., et al. (2011) · Science · doi:10.1126/science.1202947 · Cited by 1,860 · cited 1×
“This nonautonomous CTLA-4–mediated regulation is at least partly dependent on control of the antigen presenting capacity of the APCs by CD80 and CD86 modulation (29, 30) or by induction of the immune suppressive agent kynurenine (31).”
BackgroundCTLA-4 is a second receptor for the B cell activation antigen B7.
Linsley, P. S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.3.561 · Cited by 1,685 · cited 2×
“Autonomous mechanisms include among others internal signaling that leads to cell cycle arrest (21, 22), as well as competition with CD28 for interaction with CD80 and CD86 on antigen presenting cells (APCs) (23, 24).”
BackgroundCodarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191 · cited 1×
“Proinflammatory cytokines in general and GMCSF in particular are crucial for development of EAE (42).”
BackgroundHorvat, T. Z., Adel, N. G., Dang, T.-O., Momtaz, P., Postow, M. A., Callahan, M. K., Carvajal, R. D., Dickson, M. A., D'Angelo, S. P., Woo, K. M., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.60.8448 · Cited by 1,064
Molecular Basis of T Cell Inactivation by CTLA-4
Lee, K.-M., Chuang, E., Griffin, M., Khattri, R., Hong, D. K., Zhang, W., Straus, D., Samelson, L. E., Thompson, C. B., & Bluestone, J. A. (1998) · Science · doi:10.1126/science.282.5397.2263 · Cited by 684
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
van der Merwe, P. A., Bodian, D. L., Daenke, S., Linsley, P., & Davis, S. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.393 · Cited by 551 · cited 1×
“Autonomous mechanisms include among others internal signaling that leads to cell cycle arrest (21, 22), as well as competition with CD28 for interaction with CD80 and CD86 on antigen presenting cells (APCs) (23, 24).”
BackgroundBlockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
Read, S., Greenwald, R., Izcue, A., Robinson, N., Mandelbrot, D., Francisco, L., Sharpe, A. H., & Powrie, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4376 · Cited by 434
Cited by
CTLA-4: a moving target in immunotherapy
Rowshanravan, B., Halliday, N., & Sansom, D. M. (2018) · Blood · doi:10.1182/blood-2017-06-741033 · Cited by 1,233
Regulatory T Cells and Human Disease
Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,120
Self-citationHuman FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726
Self-citationNF-κB: At the Borders of Autoimmunity and Inflammation
Barnabei, L., Laplantine, E., Mbongo, W., Rieux-Laucat, F., & Weil, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.716469 · Cited by 630
Cardiovascular toxicities associated with immune checkpoint inhibitors
Hu, J.-R., Florido, R., Lipson, E. J., Naidoo, J., Ardehali, R., Tocchetti, C. G., Lyon, A. R., Padera, R. F., Johnson, D. B., & Moslehi, J. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz026 · Cited by 508
Metadata
- Authors
- Klocke, K., Sakaguchi, S., Holmdahl, R., & Wing, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-04-11
- Volume
- 113
- Issue
- 17
- Pages
- E2383-92
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2338484013
- Cited by
- 232
- References
- 9
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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