Cited by 188Stress Responses and CortisolMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla

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Dum, Richard P., Levinthal, David J., Strick, Peter L.·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1605044113PMC PMC5024624

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Abstract

Significance: How does the “mind” (brain) influence the “body” (internal organs)? We identified key areas in the primate cerebral cortex that are linked through multisynaptic connections to the adrenal medulla. The most substantial influence originates from a broad network of motor areas that are involved in all aspects of skeletomotor control from response selection to motor preparation and movement execution. A smaller influence originates from a network in medial prefrontal cortex that is involved in the regulation of cognition and emotion. Thus, cortical areas involved in the control of movement, cognition, and affect are potential sources of central commands to influence sympathetic arousal. These results provide an anatomical basis for psychosomatic illness where mental states can alter organ function.

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Authors: Dum, R. P., Levinthal, D. J., & Strick, P. L.
Affiliations: University of Pittsburgh (US)
Corresponding author: Strick, Peter L.
ORCID: Levinthal, David J.
Strick, Peter L.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2016-08-15
Volume: 113
Issue: 35
Pages: 9922-9927
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1605044113
PMC: PMC5024624
OpenAlex: W2512266290
Cited by: 188
References: 84
Citations by year: 2026: 12 · 2025: 14 · 2024: 8 · 2023: 12 · 2022: 16 · 2021: 28 · 2020: 18 · 2019: 34 · 2018: 20 · 2017: 22 · 2016: 4
FWCI: 17.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/preview_site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | NIH | National Institute of Neurological Disorders and Stroke (R01 NS24328, P40 OD010996, P30 NS076405)
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK063922, K08 DK101756)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: adrenal medulla, cerebral cortex, supplementary motor area, anterior cingulate cortex, medial prefrontal cortex, motor cortex, somatosensory cortex, sympathetic nervous system, autonomic regulation, psychosomatic disorders, chronic stress, depression, neural circuits
MeSH terms: Adrenal Medulla, Animals, Biological Transport, Cebus, Cerebral Cortex, Cognition, Female, Gyrus Cinguli, Humans, Male, Motor Cortex, Movement, Nerve Net, Neural Pathways, Rabies, Rabies virus, Prefrontal Cortex

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Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla

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