Neural circuits of interoception
Open accessAbstract
The present paper considers recent progress in our understanding of the afferent/ascending neural pathways and neural circuits of interoception. Of particular note is the extensive role of rostral neural systems, including cortical systems, in the recognition of internal body states, and the reciprocal role of efferent/descending systems in the regulation of those states. Together these reciprocal interacting networks entail interoceptive circuits that play an important role in a broad range of functions beyond the homeostatic maintenance of physiological steady-states. These include the regulation of behavioral, cognitive, and affective processes across conscious and nonconscious levels of processing. We highlight recent advances and knowledge gaps that are important for accelerating progress in the study of interoception.
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Precision signals tune the different incoming predictions and prediction errors through engagement of the salience network.
“Therefore, precision signals (the third principle) tune the different incoming predictions and prediction errors through engagement of the salience network.[113][114][115]”
From A new science of emotion: implications for functional neurological disorder (2022) · cites this paper as [114]
The Autonomic Efferent Pathways section says mice can modify interoceptive predictions in response to contextual changes, and the Integration section discusses feedback, feedforward, and incoming signals. Neither passage says that precision signals tune predictions or prediction errors through the salience network; searches for those terms found no such account in our copy. Page numbers were not available. (LLM, conf=0.78)
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Self-citation
- Authors
- Berntson, G. G., & Khalsa, S. S.
- Affiliations
- The Ohio State University (US)
- Laureate Institute for Brain Research (US)
- Corresponding author
- Berntson, Gary G.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 44
- Issue
- 1
- Pages
- 17-28
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC8054704
- OpenAlex
- W3116371286
- Cited by
- 419
- References
- 120
- Citations by year
- 2026: 73 · 2025: 120 · 2024: 94 · 2023: 55 · 2022: 45 · 2021: 26 · 2020: 6
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ohio State University Emeritus Academy
- National Institute of Mental Health (K23MH112949)
- National Institute of General Medical Sciences (P20GM121312)
- the William K. Warren Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- interoception, neural circuits, homeostasis, emotional processing, cognitive processes, behavioral regulation
- MeSH terms
- Awareness, Homeostasis, Humans, Neural Pathways, Interoception
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