The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Spatially patterned matrix elasticity directs stem cell fate
Open accessAbstract
Significance: The expansion and differentiation of human mesenchymal stem cells (hMSCs), an important cell type that is frequently used in stem-cell–based therapies, are regulated by interactions with their local extracellular microenvironment. Matrix stiffness is one of the key regulators, but often varies in space at a range of length scales in the local niche. To better understand and harness cell–matrix interactions, we used an innovative phototunable hydrogel platform to provide compelling evidence that the magnitude and spatial organization of matrix mechanics influence hMSCs through systematic regulation of cytoskeletal tension and transcriptional activation. These findings may have important implications in deepening our fundamental understanding of the role of extracellular matrix organization on disease, aging, and regenerative processes.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Remodelling the extracellular matrix in development and disease
Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748
Self-citationSubstrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P., & Blau, H. M. (2010) · Science · doi:10.1126/science.1191035 · Cited by 1,587
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014) · Nature Materials · doi:10.1038/nmat3980 · Cited by 1,082
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985
Cited by
Mechanical forces direct stem cell behaviour in development and regeneration
Vining, K. H., & Mooney, D. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.108 · Cited by 1,656
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Design and Applications of Photoresponsive Hydrogels
Li, L., Scheiger, J. M., & Levkin, P. A. (2019) · Advanced Materials · doi:10.1002/adma.201807333 · Cited by 733
Spatiotemporal hydrogel biomaterials for regenerative medicine
Brown, T. E., & Anseth, K. S. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00445a · Cited by 428
Self-citationJanmey, P. A., Fletcher, D. A., & Reinhart-King, C. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 422
Metadata
- Authors
- Yang, C., DelRio, F. W., Ma, H., Killaars, A. R., Basta, L. P., Kyburz, K. A., & Anseth, K. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-07-19
- Volume
- 113
- Issue
- 31
- Pages
- E4439-45
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2503067859
- Cited by
- 217
- References
- 8
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, C., DelRio, F. W., Ma, H., Killaars, A. R., Basta, L. P., Kyburz, K. A., & Anseth, K. S. (2016). Spatially patterned matrix elasticity directs stem cell fate. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1609731113
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
