Cited by 376Cellular Mechanics and Interactions3D Printing in Biomedical ResearchCancer Cells and Metastasis

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Oriented collagen fibers direct tumor cell intravasation

Open access

Han, Weijing, Chen, Shaohua, Yuan, Wei, Fan, Qihui, Tian, Jianxiang, Wang, Xiaochen, Chen, Longqing, Zhang, Xixiang, Wei, Weili, Liu, Ruchuan, Qu, Junle, Jiao, Yang, Austin, Robert H., Liu, Liyu·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1610347113PMC PMC5056065

Open this paper in CoChat — free account

Abstract

In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

Integrity signals

Registry

Crossref · 10.1073/pnas.1610347113

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis
Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3963 · Cited by 296
Retracted
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Collagen reorganization at the tumor-stromal interface facilitates local invasion
Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-38 · Cited by 1,804
Collagen density promotes mammary tumor initiation and progression
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,394
Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma
Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,321
Mechanical properties of hydrogels and their experimental determination
Anseth, K. S., Bowman, C. N., & Brannon-Peppas, L. (1996) · Biomaterials · doi:10.1016/0142-9612(96)87644-7 · Cited by 1,156
Effects of radiation on normal tissue: consequences and mechanisms
Stone, H. B., Coleman, C. N., Anscher, M. S., & McBride, W. H. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01191-4 · Cited by 934
β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
Soto, C. A., Sigurdsson, E. M., Morelli, L., Kumar, R., Castaño, E. M., & Frangione, B. (1998) · Nature Medicine · doi:10.1038/nm0798-822 · Cited by 874
Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
Zervantonakis, I. K., Hughes-Alford, S. K., Charest, J. L., Condeelis, J. S., Gertler, F. B., & Kamm, R. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210182109 · Cited by 872

Flagged first, then by citations

Show all 48 references

Sorted by citations

Items 101–200 of 375

Collagen Fiber Array of Peritumoral Stroma Influences Epithelial-to-Mesenchymal Transition and Invasive Potential of Mammary Cancer Cells
Franchi, M., Masola, V., Bellin, G., Onisto, M., Karamanos, K., & Piperigkou, Z. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020213 · Cited by 37
Understanding wound inflammation.
Collier, M. A. (2003) · PubMed · Cited by 35
Geometric Dependence of 3D Collective Cancer Invasion
Kim, J., Zheng, Y., Alobaidi, A. A., Nan, H., Tian, J., Jiao, Y., & Sun, B. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.01.008 · Cited by 34
Self-citation
Extracellular Vesicles in Breast Cancer: From Biology and Function to Clinical Diagnosis and Therapeutic Management
Loric, S., Denis, J. A., Desbène, C., Sabbah, M., & Conti, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087208 · Cited by 42
Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches
Kang, S., Ughetta, M. E., Zhang, J. Y., Marallano, V. J., Sattiraju, A., Hannah, T., Wahane, S., Ramakrishnan, A., Estill, M. S., Tsankova, N. M., et al. (2025) · Nature Cancer · doi:10.1038/s43018-025-00985-4 · Cited by 34
Distinct phenotypes of cancer cells on tissue matrix gel
Ruud, K. F., Hiscox, W. C., Yu, I., Chen, R. K., & Li, W. (2020) · Breast Cancer Research · doi:10.1186/s13058-020-01321-7 · Cited by 33
Label-Free Histology and Evaluation of Human Pancreatic Cancer with Coherent Nonlinear Optical Microscopy
Zhang, L., Zou, X., Huang, J., Fan, J., Sun, X., Zhang, B., Zheng, B., Guo, C., Fu, D., Yao, L., et al. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03861 · Cited by 33
Molecular aspects of brain metastases in breast cancer
Tomasik, B., Bieńkowski, M., Górska, Z., Gutowska, K., Kumięga, P., Jassem, J., & Duchnowska, R. (2023) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2023.102521 · Cited by 31
The extracellular matrix in inflammation and cancer
Zhang, W., Xiang, Y., Lu, C., Wang, F., Ren, H., Wu, H., & Yan, M. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00415-6 · Cited by 34
Realizations of highly heterogeneous collagen networks via stochastic reconstruction for micromechanical analysis of tumor cell invasion
Nan, H., Liang, L., Chen, G., Liu, L., Liu, R., & Jiao, Y. (2018) · Physical review. E · doi:10.1103/physreve.97.033311 · Cited by 30
Self-citation
Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination
Fujimoto, H., Yoshihara, M., Rodgers, R. J., Iyoshi, S., Mogi, K., Miyamoto, E., Hayakawa, S., Hayashi, M., Nomura, S., Kitami, K., et al. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10169-8 · Cited by 29
Microengineered 3D collagen gels with independently tunable fiber anisotropy and directionality
Ahmed, A., Joshi, I. M., Larson, S., Mansouri, M., Gholizadeh, S., Allahyari, Z., Forouzandeh, F., Borkholder, D. A., Gaborski, T. R., & Abhyankar, V. V. (2021) · Advanced Materials Technologies · doi:10.1002/admt.202001186 · Cited by 27
Collective Cell Migration in a Fibrous Environment: A Hybrid Multiscale Modelling Approach
Suveges, S., Chamseddine, I. M., Rejniak, K. A., Eftimie, R., & Trucu, D. (2021) · Frontiers in Applied Mathematics and Statistics · doi:10.3389/fams.2021.680029 · Cited by 27
Application of Microfluidic Systems for Breast Cancer Research
Frankman, Z. D., Jiang, L., Schroeder, J. A., & Zohar, Y. (2022) · Micromachines · doi:10.3390/mi13020152 · Cited by 28
Electrospun polyurethane fibrous membranes of mimicked extracellular matrix for periodontal ligament: Molecular behavior, mechanical properties, morphology, and osseointegration
Watcharajittanont, N., Putson, C., Pripatnanont, P., & Meesane, J. (2019) · Journal of Biomaterials Applications · doi:10.1177/0885328219874601 · Cited by 26
Collagen remodeling-mediated signaling pathways and their impact on tumor therapy
Yuan, Z., Lin, B., Wang, C., Yan, Z., Yang, F., & Su, H. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108330 · Cited by 26
Breast cancer brain metastasis: from etiology to state-of-the-art modeling
Kamalabadi‐Farahani, M., Gharibshahian, M., Rezvani, A., & Vaez, A. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00352-w · Cited by 26
Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility
Böhringer, D., Bauer, A., Moravec, I., Bischof, L., Kah, D., Mark, C., Grundy, T. J., Görlach, E., O’Neill, G. M., Budday, S., et al. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.11.004 · Cited by 26
Overcoming the Tumor Collagen Barriers: A Multistage Drug Delivery Strategy for DDR1‐Mediated Resistant Colorectal Cancer Therapy
Cui, G., Deng, S., Zhang, B., Wang, M., Lin, Z., Lan, X., Li, Z., Yao, G., Yu, M., & Yan, J. (2024) · Advanced Science · doi:10.1002/advs.202402107 · Cited by 25
Microfluidic vascular models of tumor cell extravasation
Kim, S., Wan, Z., Jeon, J. S., & Kamm, R. D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1052192 · Cited by 25
Periostin+ Stromal Cells Guide Lymphovascular Invasion by Cancer Cells
Null, J. L., Kim, D. J., McCann, J. V., Pramoonjago, P., Fox, J. W., Zeng, J., Kumar, P., Edatt, L., Pecot, C. V., & Dudley, A. C. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-2412 · Cited by 25
Oncogenic Linear Collagen VI of Invasive Breast Cancer Is Induced by CCL5
Brett, E. A., Sauter, M. A., Timmins, É. M., Azimzadeh, O., Rosemann, M., Merl‐Pham, J., Hauck, S. M., Nelson, P. J., Becker, K., Schunn, I., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040991 · Cited by 24
Microengineering 3D Collagen Matrices with Tumor‐Mimetic Gradients in Fiber Alignment
Joshi, I. M., Mansouri, M., Ahmed, A., Silva, D. D., Simon, R. A., Esmaili, P., Desa, D. E., Elias, T. M., Brown, E. B., & Abhyankar, V. V. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202308071 · Cited by 24
In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types
Matossian, M. D., Chang, T. C., Wright, M. K., Burks, H. E., Elliott, S., Sabol, R. A., Wathieu, H., Windsor, G. O., Alzoubi, M. S., King, C. T., et al. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02677-8 · Cited by 24
Collagen I dysregulation is pivotal for ovarian cancer progression
Sarwar, M., Sykes, P. H., Chitcholtan, K., & Evans, J. J. (2021) · Tissue and Cell · doi:10.1016/j.tice.2021.101704 · Cited by 26
Regulation of migration of chemotactic tumor cells by the spatial distribution of collagen fiber orientation
Azimzade, Y., Saberi, A. A., & Sahimi, M. (2019) · Physical review. E · doi:10.1103/physreve.99.062414 · Cited by 23
Quantifying Breast Cancer-Driven Fiber Alignment and Collagen Deposition in Primary Human Breast Tissue
Gurrala, R., Byrne, C. E., Brown, L. M., Tiongco, R. F. P., Matossian, M. D., Savoie, J. J., Collins‐Burow, B. M., Burow, M. E., Martin, E. C., & Lau, F. H. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.618448 · Cited by 23
Mechanoimmunology in the solid tumor microenvironment
Golo, M., Newman, P. L. H., Kempe, D., & Biro, M. (2024) · Biochemical Society Transactions · doi:10.1042/bst20231427 · Cited by 23
In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
Luthria, G., Li, R., Wang, S., Prytyskach, M., Köhler, R. H., Lauffenburger, D. A., Mitchison, T. J., Weissleder, R., & Miller, M. A. (2020) · Nature Communications · doi:10.1038/s41467-020-17147-y · Cited by 23
The Matrix Reloaded—The Role of the Extracellular Matrix in Cancer
Raskov, H., Gaggar, S., Tajik, A., Orhan, A., & Gögenür, I. (2023) · Cancers · doi:10.3390/cancers15072057 · Cited by 23
Landscape of Genetic Mutations in Appendiceal Cancers
Constantin, M., Mătanie, C., Petrescu, L., Bolocan, A., Andronic, O., Bleoţu, C., Mitache, M. M., Tudorache, S. I., & Vrâncianu, C. O. (2023) · Cancers · doi:10.3390/cancers15143591 · Cited by 22
Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology
Millet, M., Messaoud, R. B., Luthold, C., & Bordeleau, F. (2019) · Micromachines · doi:10.3390/mi10060418 · Cited by 24
Super resolution measurement of collagen fibers in biological samples: Validation of a commercial solution for multiphoton microscopy
Barlow, A. M., Mostaço-Guidolin, L. B., Osei, E. T., Booth, S., & Hackett, T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229278 · Cited by 23
Accuracy of diffusion-weighted imaging-magnetic resonance in differentiating functional from non-functional pituitary macro-adenoma and classification of tumor consistency
Taheri, M. S., Kimia, F., Mehrnahad, M., Rad, H. S., Haghighatkhah, H., Moradi, A., Kazerooni, A. F., Alviri, M., & Absalan, A. (2018) · The Neuroradiology Journal · doi:10.1177/1971400918809825 · Cited by 22
Polarized Micro-Raman Spectroscopy and 2D Convolutional Neural Network Applied to Structural Analysis and Discrimination of Breast Cancer
Shang, L., Tang, J., Wu, J., Shang, H., Huang, X., Bao, Y., Xu, Z., Wang, H., & Yin, J. (2022) · Biosensors · doi:10.3390/bios13010065 · Cited by 21
Label-Free Imaging of Blood Vessels in Human Normal Breast and Breast Tumor Tissue Using Multiphoton Microscopy
Xi, G., Cao, N., Guo, W., Kang, D., Chen, Z., He, J., Ren, W., Shen, T., Wang, C., & Chen, J. (2019) · Scanning · doi:10.1155/2019/5192875 · Cited by 22
Association of Tumor-Associated Collagen Signature With Prognosis and Adjuvant Chemotherapy Benefits in Patients With Gastric Cancer
Chen, D., Chen, H., Chi, L., Fu, M., Wang, G., Wu, Z., Xu, S., Sun, C., Xu, X., Lin, L., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.36388 · Cited by 21
An Intrinsically Nontrimerizing Peptide Probe for Specifically Targeting Pathological Collagen in Connective Tissues
Cai, X., Wei, W., Bi, Y., Liu, Z., Bai, Z., Lei, J., & Xiao, J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202004532 · Cited by 20
Self-citation
Multiphoton Microscopy for Identifying Collagen Signatures Associated with Biochemical Recurrence in Prostate Cancer Patients
Pavlova, I. P., Nair, S. S., Lundon, D., Sobótka, S., Roshandel, R., Treacy, P., Ratnani, P., Brody, R., Epstein, J. I., Ayala, G. E., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111061 · Cited by 20
Click chemistry functionalization of self‐assembling peptide hydrogels
Sharick, J. T., Atieh, A. J., Gooch, K. J., & Leight, J. L. (2022) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37460 · Cited by 22
Biophysical cues of in vitro biomaterials-based artificial extracellular matrix guide cancer cell plasticity
Tang, R.-Z., & Liu, X. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100607 · Cited by 21
Inference of long-range cell-cell force transmission from ECM remodeling fluctuations
Nahum, A., Koren, Y., Ergaz, B., Natan, S., Miller, G., Tamir, Y., Goren, S., Kolel, A., Jagadeeshan, S., Elkabets, M., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05179-1 · Cited by 20
Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases
Song, K., Wang, Z., Liu, R., Chen, G., & Liu, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19040935 · Cited by 20
Self-citation
Response of collagen matrices under pressure and hydraulic resistance in hydrogels
Maity, D., Li, Y., Chen, Y., & Sun, S. X. (2019) · Soft Matter · doi:10.1039/c8sm02143k · Cited by 20
Mechanical Interaction between Cells Facilitates Molecular Transport
Gomez, D., Natan, S., Shokef, Y., & Lesman, A. (2019) · Advanced Biosystems · doi:10.1002/adbi.201900192 · Cited by 20
Disentangling the fibrous microenvironment: designer culture models for improved drug discovery
Ort, C., Lee, W., Kalashnikov, N., & Moraes, C. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1822815 · Cited by 20
Tumor extracellular matrix: lessons from the second-harmonic generation microscopy
Natal, R. D. A., Adur, J. F., Cesar, C. L., & Vassallo, J. (2021) · Surgical and Experimental Pathology · doi:10.1186/s42047-021-00089-0 · Cited by 24
The tumour microenvironment modulates cancer cell intravasation
Agrawal, A., Shahreza, S., Javanmardi, Y., Szita, N., & Moeendarbary, E. (2022) · Organs-on-a-Chip · doi:10.1016/j.ooc.2022.100024 · Cited by 20
Capturing the spatial and temporal dynamics of tumor stroma for on-chip optimization of microenvironmental targeting nanomedicine
Imparato, G., Urciuolo, F., Mazio, C., & Netti, P. A. (2022) · Lab on a Chip · doi:10.1039/d2lc00611a · Cited by 19
The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration
Castro-Abril, H. A., Heras, J., del Barrio, J., Paz-Artigas, L., Alcaine, C., Pérez-Aliacar, M., Garzón–Alvarado, D. A., Doblaré, M., & Ochoa, I. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300108 · Cited by 19
Longer collagen fibers trigger multicellular streaming on soft substrates via enhanced forces and cell–cell cooperation
Sarker, B., Bagchi, A., Walter, C., de Almeida, J. A. A., & Pathak, A. (2019) · Journal of Cell Science · doi:10.1242/jcs.226753 · Cited by 19
SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment
Sharma, V. P., Williams, J. K., Leung, E., Sanders, J., Eddy, R. J., Castracane, J., Oktay, M. H., Entenberg, D. R., & Condeelis, J. S. (2021) · Cells · doi:10.3390/cells10061549 · Cited by 18
Strategies to control cellular spatial organization in microphysiological systems
Truong, H. D., Ge, Z., Chng, E., Tran, Y.-V., Zhang, Y., & Lim, C. T. (2026) · Microsystems & Nanoengineering · doi:10.1038/s41378-025-01141-9 · Cited by 18
Building Large DNA Bundles via Controlled Hierarchical Assembly of DNA Tubes
Zhang, Y., Yang, D., Wang, P., & Ke, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c01342 · Cited by 17
Stromal Cells Promote Neovascular Invasion Across Tissue Interfaces
Strobel, H. A., LaBelle, S. A., Krishnan, L., Dale, J. R., Rauff, A., Poulson, A. M., Bader, N., Beare, J. E., Aliaj, K., Weiss, J. A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01026 · Cited by 17
High-Throughput Characterization of Cell Adhesion Strength Using Long-Channel Constriction-Based Microfluidics
Wei, M., Zhang, F., Zhang, R., Lin, J., & Yang, N. (2021) · ACS Sensors · doi:10.1021/acssensors.1c01037 · Cited by 17
Single cell imaging-based chromatin biomarkers for tumor progression
Venkatachalapathy, S., Jokhun, D. S., Andhari, M. D., & Shivashankar, G. V. (2021) · Scientific Reports · doi:10.1038/s41598-021-02441-6 · Cited by 17
EMT-related cell-matrix interactions are linked to states of cell unjamming in cancer spheroid invasion
van der Net, A., Rahman, Z., Bordoloi, A., Muntz, I., ten Dijke, P., Boukany, P. E., & Koenderink, G. H. (2024) · iScience · doi:10.1016/j.isci.2024.111424 · Cited by 16
The microenvironment and cytoskeletal remodeling in tumor cell invasion
Azadi, S., & Tafazzoli‐Shadpour, M. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.06.003 · Cited by 16
Harnessing mechanobiology for kidney organoid research
Nauryzgaliyeva, Z., Corredera, I. G., Garreta, E., & Montserrat, N. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1273923 · Cited by 18
Association of the pathomics-collagen signature with lymph node metastasis in colorectal cancer: a retrospective multicenter study
Jiang, W., Wang, H., Dong, X., Zhao, Y., Long, C., Chen, D., Yan, B., Cheng, J., Lin, Z., Zhuo, S., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04851-2 · Cited by 17
Shear Wave Elasticity Measurements of Three-Dimensional Cancer Cell Cultures Using Laser Speckle Contrast Imaging
Chao, P., Liu, W., You, S., & Li, P. (2018) · Scientific Reports · doi:10.1038/s41598-018-32763-x · Cited by 16
Multiphoton Microscopy Reveals DAPK1-Dependent Extracellular Matrix Remodeling in a Chorioallantoic Membrane (CAM) Model
Kunze, P., Kreiss, L. A., Novosadová, V., Roehe, A. V., Steinmann, S. M., Procházka, J., Geppert, C. I., Hartmann, A., Schürmann, S., Friedrich, O., et al. (2022) · Cancers · doi:10.3390/cancers14102364 · Cited by 16
FOXL1+ Telocytes in mouse colon orchestrate extracellular matrix biodynamics and wound repair resolution
Pomerleau, V., Nicolás, V. R., Jurkovic, C.-M., Faucheux, N., Lauzon, M.-A., Boisvert, F., & Perreault, N. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2022.104755 · Cited by 16
Proteome and phosphoproteome signatures of recurrence for HPV+ head and neck squamous cell carcinoma
Kaneko, T., Zeng, P. Y., Liu, X., Abdo, R., Barrett, J. W., Zhang, Q., Nichols, A. C., & Li, S. S. ‐. (2022) · Communications Medicine · doi:10.1038/s43856-022-00159-8 · Cited by 15
Immunotherapy: breaching the barriers for cancer treatment
Martínez, V. G., Park, D., & Acton, S. E. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0214 · Cited by 15
Sensing Traction Force on the Matrix Induces Cell–Cell Distant Mechanical Communications for Self-Assembly
Ouyang, M., Qian, Z., Bu, B., Jin, Y., Wang, J., Zhu, Y., Liu, L., Pan, Y., & Deng, L. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01035 · Cited by 15
Self-citation
Matrix anisotropy promotes angiogenesis in a density-dependent manner
LaBelle, S. A., Dinkins, S. S., Hoying, J. B., Budko, E. V., Rauff, A., Strobel, H. A., Lin, A. H., & Weiss, J. A. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00072.2022 · Cited by 15
Novel inverse finite-element formulation for reconstruction of relative local stiffness in heterogeneous extra-cellular matrix and traction forces on active cells
Chen, S., Xu, W., Kim, J., Nan, H., Zheng, Y., Sun, B., & Jiao, Y. (2019) · Physical Biology · doi:10.1088/1478-3975/ab0463 · Cited by 15
Self-citation
Association of the Collagen Signature in the Tumor Microenvironment With Recurrence and Survival of Patients With T4N0M0 Colon Cancer
Chen, W., Dong, S., Liu, X., Wang, G., Xu, S., Lei, S., Zhuo, S., & Yan, J. (2021) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0000000000001907 · Cited by 15
Mapping Organizational Changes of Fiber‐Like Structures in Disease Progression by Multiparametric, Quantitative Imaging
Qian, S., Meng, J., Feng, Z., Zhou, L., Jiang, S., Wang, Y., Ye, Z., Zhuo, S., Chen, J., Li, X., et al. (2022) · Laser & Photonics Review · doi:10.1002/lpor.202100576 · Cited by 15
Colorectal Cancer Bioengineered Microtissues as a Model to Replicate Tumor-ECM Crosstalk and Assess Drug Delivery Systems In Vitro
Rocca, A. L., Gregorio, V. D., Lagreca, E., Vecchione, R., Netti, P. A., & Imparato, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065678 · Cited by 14
Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices
Chen, D., Du, Y. M., Llewellyn, J., Bonna, A., Zuo, B., Janmey, P. A., Farndale, R. W., & Wells, R. G. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107968 · Cited by 14
Microstructural densification and alignment by aspiration‐ejection influence cancer cell interactions with three‐dimensional collagen networks
Huynh, R. N., Yousof, M., Ly, K. L., Gombedza, F., Luo, X., Bandyopadhyay, B. C., & Raub, C. B. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27308 · Cited by 14
Neoplastic–Stromal Cell Cross-talk Regulates Matrisome Expression in Pancreatic Cancer
Honselmann, K. C., Finetti, P., Birnbaum, D. J., Monsalve, C. S., Wellner, U. F., Begg, S. K. S., Nakagawa, A., Hank, T. P., Li, A., Goldsworthy, M. A., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0439 · Cited by 15
Collagen-Specific Molecular Magnetic Resonance Imaging of Prostate Cancer
Kader, A., Kaufmann, J. O., Mangarova, D. B., Möckel, J., Adams, L. C., Brangsch, J., Heyl, J. L., Zhao, J., Verlemann, C., Kärst, U., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010711 · Cited by 15
Microclaw Array Fabricated by Single Exposure of Femtosecond Airy Beam and Self-Assembly for Regulating Cell Migratory Plasticity
Wang, C., Rao, R., Cai, Z. Y., Yang, H., Zhang, L., Ji, S., Zhang, C., Gao, D. Y., Hu, Y., Li, J., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c11577 · Cited by 14
Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro
Morgan, M. M., Schuler, L. A., Ciciliano, J. C., Johnson, B. P., Alarid, E. T., & Beebe, D. J. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa002 · Cited by 14
Key Regulatory miRNAs and their Interplay with Mechanosensing and Mechanotransduction Signaling Pathways in Breast Cancer Progression
Najminejad, H., Farhadihosseinabadi, B., Dabaghian, M., Dezhkam, A., Yousefabadi, E. R., Najminejad, R., Abdollahpour‐Alitappeh, M., Karimi, M. H., Bagheri, N., Mahi‐Birjand, M., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-1229 · Cited by 14
Collagen dynamics in the breast cancer tumor microenvironment and therapeutic perspectives
Wu, D., Liu, L., Ying, J., Qian, Z., You, Y., Ning, X., Zhang, F., Wang, Y., & Zhang, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-04182-8 · Cited by 13
Self-citation
Directed invasion of cancer cell spheroids inside 3D collagen matrices oriented by microfluidic flow in experiment and simulation
Geiger, F., Schnitzler, L. G., Brugger, M. S., Westerhausen, C., & Engelke, H. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264571 · Cited by 13
Emergence of bidirectional cell laning from collective contact guidance
Lacroix, M., Smeets, B., Blanch-Mercader, C., Bell, S., Giuglaris, C., Chen, H., Prost, J., & Silberzan, P. (2024) · Nature Physics · doi:10.1038/s41567-024-02510-3 · Cited by 13
Multitask machine learning-based tumor-associated collagen signatures predict peritoneal recurrence and disease-free survival in gastric cancer
Fu, M., Lin, Y., Yang, J., Cheng, J., Lin, L., Wang, G., Long, C., Xu, S., Lu, J., Li, G., et al. (2024) · Gastric Cancer · doi:10.1007/s10120-024-01551-0 · Cited by 13
Microfluidic Reconstitution of Tumor Microenvironment for Nanomedical Applications
Oh, H. J., Kim, J., Kim, H., Choi, N., & Chung, S. H. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002122 · Cited by 13
Dynein‐Powered Cell Locomotion Guides Metastasis of Breast Cancer
Tagay, Y., Kheirabadi, S., Ataie, Z., Singh, R. K., Prince, O., Nguyen, A. T., Zhovmer, A. S., Ma, X., Sheikhi, A., Tsygankov, D., et al. (2023) · Advanced Science · doi:10.1002/advs.202302229 · Cited by 14
Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer
Chrabąszcz, K., Kaminska, K. H., Song, C. L., Morikawa, J., Kujdowicz, M., Michalczyk, E., Smęda, M., Stojak, M., Jasztal, A., Kazarian, S. G., et al. (2021) · Cancers · doi:10.3390/cancers13020162 · Cited by 13
Unveiling breast cancer metastasis through an advanced X-ray imaging approach
Conceição, A. L. C., Müller, V., Burandt, E., Mohme, M., Nielsen, L., Liebi, M., & Haas, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-51945-4 · Cited by 15
Collagen signature adds prognostically significant information to staging for breast cancer
Li, Z., Kang, D.-H., Xu, S., Xi, G., Li, L., Zheng, L., Guo, W., Fu, F., Wang, C., Ma, J., et al. (2024) · ESMO Open · doi:10.1016/j.esmoop.2024.103990 · Cited by 12
Demonstration of Enhancement of Tumor Intravasation by Dicarbonyl Stress Using a Microfluidic Organ‐on‐chip
Kumar, N., Samanta, B., Manattayil, J. K., Raghunathan, V., Sen, P., & Bhat, R. (2025) · Small · doi:10.1002/smll.202405998 · Cited by 12
Roles of Interactions Between Cells and Extracellular Matrices for Cell Migration and Matrix Remodeling
Li, J., Jung, W., Nam, S., Chaudhuri, O., & Kim, T. (2019) · Studies in mechanobiology, tissue engineering and biomaterials · doi:10.1007/978-3-030-20182-1_8 · Cited by 13
Achieving coalesced breathability, mechanical and shape memory properties of collagen fibrous matrix through complexing with chromium (III)
Han, Y., Jiang, Y., Hu, J., & Chen, X. (2019) · Materials & Design · doi:10.1016/j.matdes.2019.108206 · Cited by 12
A mechanistic protrusive-based model for 3D cell migration
Merino-Casallo, F., Gómez‐Benito, M. J., Martínez-Cantín, R., & García‐Aznar, J. M. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151255 · Cited by 12
Adhesion strength and anti-tumor agents regulate vinculin of breast cancer cells
Metsiou, D. N., Deligianni, D. D., Giannopoulou, E., Kalofonos, H. P., Koutras, A. K., & Athanassiou, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.811508 · Cited by 12
Shannon entropy for time-varying persistence of cell migration
Liu, Y., Jiao, Y., Fan, Q., Zheng, Y., Li, G., Yao, J., Wang, G., Lou, S., Chen, G., Shuai, J., et al. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.04.026 · Cited by 13
Self-citation
Diversity of collective migration patterns of invasive breast cancer cells emerging during microtrack invasion
Liu, R., Song, K., Hu, Z., Cao, W., Shuai, J., Chen, S., Nan, H., Zheng, Y., Jiang, X., Zhang, H., et al. (2019) · Physical review. E · doi:10.1103/physreve.99.062403 · Cited by 12
Self-citation
Using Microfluidics to Align Matrix Architecture and Generate Chemokine Gradients Promotes Directional Branching in a Model of Epithelial Morphogenesis
Lichtenberg, J. Y., Leonard, C. E., Sterling, H. R., Agreda, V. S., & Hwang, P. Y. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00245 · Cited by 11
Human Breast Extracellular Matrix Microstructures and Protein Hydrogel 3D Cultures of Mammary Epithelial Cells
Keller, C. R., Hu, Y., Ruud, K. F., VanDeen, A. E., Martinez, S. R., Kahn, B. T., Zhang, Z., Chen, R. K., & Li, W. (2021) · Cancers · doi:10.3390/cancers13225857 · Cited by 11
Mechanomimetic 3D Scaffolds as a Humanized In Vitro Model for Ovarian Cancer
Paradiso, F., Lenna, S., Gazze, S. A., García-Parra, J., Murphy, K., Margarit, L., González, D., Francis, L. W., & Taraballi, F. (2022) · Cells · doi:10.3390/cells11050824 · Cited by 11
Tissue density in the progression of breast cancer: Bedside to bench and back again
Fabiano, E. D., Zhang, J., & Reinhart‐King, C. A. (2022) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2022.100383 · Cited by 11
Integrative Analysis Constructs an Extracellular Matrix-Associated Gene Signature for the Prediction of Survival and Tumor Immunity in Lung Adenocarcinoma
Xiao, L., Li, Q., Huang, Y., Fan, Z., Qin, W., Liu, B., & Yuan, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.835043 · Cited by 11

Authors: Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., Qu, J., Jiao, Y., Austin, R. H., & Liu, L.
Affiliations: Chinese Academy of Sciences (CN)
Arizona State University (US)
Shenzhen University (CN)
King Abdullah University of Science and Technology (SA)
Chongqing University (CN)
ORCID: Han, Weijing
Chen, Shaohua
Fan, Qihui
Tian, Jianxiang
Wang, Xiaochen
Zhang, Xixiang
Wei, Weili
Liu, Ruchuan
Qu, Junle
Jiao, Yang
Austin, Robert H.
Liu, Liyu
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2016-09-23
Volume: 113
Issue: 40
Pages: 11208-11213
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1610347113
PMC: PMC5056065
OpenAlex: W2464386848
Cited by: 376
References: 48
Citations by year: 2026: 15 · 2025: 42 · 2024: 46 · 2023: 44 · 2022: 51 · 2021: 51 · 2020: 50 · 2019: 41 · 2018: 21 · 2017: 12 · 2016: 1
FWCI: 17.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 181 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
Funders: State Key Development Program Basic Research China (2013CB837200)
National Science Foundation China (11474345, 11274200)
Beijing Natural Science Foundation (7154221)
HHS | NIH | National Cancer Institute (U54CA143803)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: collagen fiber orientation, tumor cell intravasation, extracellular matrix, cell-matrix interactions, collective cell migration, breast cancer metastasis, MDA-MB-231 cells, Matrigel
MeSH terms: Biopsy, Collagen, Extracellular Matrix, Female, Humans, Neoplasm Metastasis, Neoplasms, Disease Progression, Cell Line, Tumor, Cell Proliferation, Time-Lapse Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oriented collagen fibers direct tumor cell intravasation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks