The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A hypothalamic circuit that controls body temperature
Open accessAbstract
Significance: Thermal homeostasis is essential for survival in mammals. Although it is known that temperature-sensitive neurons in the hypothalamus can control body temperature, the precise neural types and dynamics of neurons responding to changes in environmental temperature are not well defined. In this study, we identified subsets of temperature-activated neurons in two hypothalamic nuclei, the preoptic area (POA) and the dorsomedial hypothalamus (DMH), and showed that modulating their activity can lead to alterations in core temperature. The data further suggest that heat-activated GABAergic neurons in the POA reduce the activity of cold-activated neurons in the DMH, which function to increase thermogenesis and physical activity. These data identify a neural circuit that controls core temperature and thermogenesis.
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Cites
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
Petreanu, L., Huber, D., Sobczyk, A., & Svoboda, K. (2007) · Nature Neuroscience · doi:10.1038/nn1891 · Cited by 930
Warm-Sensitive Neurons that Control Body Temperature
Tan, C. L., Cooke, E. K., Leib, D. E., Lin, Y.-C., Daly, G. E., Zimmerman, C. A., & Knight, Z. A. (2016) · Cell · doi:10.1016/j.cell.2016.08.028 · Cited by 402
Zaretskaia, M. V., Zaretsky, D. V., Shekhar, A., & DiMicco, J. A. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03369-8 · Cited by 173
Cited by
Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region
Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365
IL-17a promotes sociability in mouse models of neurodevelopmental disorders
Reed, M. D., Yim, Y. S., Wimmer, R. D., Kim, H., Ryu, C., Welch, G. M., Andina, M., King, H. O., Waisman, A., Halassa, M. M., et al. (2020) · Nature · doi:10.1038/s41586-019-1843-6 · Cited by 274
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice
Kroeger, D., Absi, G., Gagliardi, C., Bandaru, S. S., Madara, J. C., Ferrari, L. L., Arrigoni, E., Münzberg, H., Scammell, T. E., Saper, C. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06590-7 · Cited by 276
The Temperature Dependence of Sleep
Harding, E. C., Franks, N. P., & Wisden, W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00336 · Cited by 261
“This maybe through activation of separate GABAergic neurons for sleep and hypothermia in the MPO and LPO, but they may also activate galinergic-GABAergic neurons to initiate sleep and body cooling.”
BackgroundInfluentialHypothalamic control of energy expenditure and thermogenesis
Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00741-z · Cited by 208
Metadata
- Authors
- Zhao, Z.-D., Yang, W. Z., Gao, C., Fu, X., Zhang, W., Zhou, Q., Chen, W., Ni, X., Lin, J.-K., Yang, J., Xu, X.-H., & Shen, W. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-01-04
- Volume
- 114
- Issue
- 8
- Pages
- 2042-2047
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2571308267
- Cited by
- 355
- References
- 4
- FWCI
- 24.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhao, Z.-D., Yang, W. Z., Gao, C., Fu, X., Zhang, W., Zhou, Q., Chen, W., Ni, X., Lin, J.-K., Yang, J., Xu, X.-H., & Shen, W. L. (2017). A hypothalamic circuit that controls body temperature. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1616255114
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