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Dnmt3a restrains mast cell inflammatory responses
Open accessAbstract
Significance Methylation of genomic DNA is an epigenetic modification at the interface between genetic information and environmental stimuli underlying many phenotypic variations in the human population as well as the pathogenesis of complex diseases. Accordingly, mutations in the de novo DNA methyltransferase enzyme DNMT3A have been identified in a number of diseases, including mast cell-related disorders. However, the role of DNA methylation and DNMT3A in regulating mast cell physiology still needs to be elucidated. Here, we found that Dnmt3a plays a critical role in modulating mast cell responsiveness to acute and chronic stimulation, potentially implicating DNA methylation-mediated processes in all types of mast cell-related diseases.
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“enhanced mast cell activity was also seen in a mouse model of allergy 94”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [94]
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“one study found that mast cells from mice that lacked Dnmt3a produced higher levels of IL-6, TNF-alpha, and IL-13 in response to stimulation with IgE in vitro”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [94]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
BEDTools: a flexible suite of utilities for comparing genomic features
Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Flagged first, then by citations
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Sorted by citations
Items 101–138 of 138
Sun, Q., Wang, S., Zeng, M., Liu, M., Zhao, C., Yi, B., Hu, S., Yu, B., & Jia, H. (2025) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.124.017915 · Cited by 8
Clonal Hematopoiesis: Origins and determinants of evolution
Mendez, L., & Patnaik, M. M. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107076 · Cited by 8
Gajagowni, S., Hopkins, S., Qadeer, Y. K., Virani, S. S., Verdonschot, J. A. J., Coombs, C. C., Amos, C. I., Nead, K. T., Jaiswal, S., & Krittanawong, C. (2024) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2024.09.001 · Cited by 8
Burns, S. S., & Kapur, R. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.021 · Cited by 9
Lee, W. J., Jung, K., Song, H., Lee, H., Park, H. E., Koh, Y., Choi, S., & Park, K. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14114 · Cited by 6
Wang, Z., Feng, S., Yao, X., Zhao, R., Li, Y., Zheng, M., Li, Z., & Wang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1620895 · Cited by 6
Xi, Z., Feng, H., Chen, K., Guo, X., Zhu, D., Zheng, J., & Li, Y. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102242 · Cited by 6
DNA demethylation regulates gene expression in IgE‐activated mouse mast cells
Paivandy, A., Grujić, M., Rafati, N., & Pejler, G. (2020) · Allergy · doi:10.1111/all.14205 · Cited by 6
Yegorov, Y. E., Poznyak, A. V., Bezsonov, E. E., Zhuravlev, A. D., Nikiforov, N. G., Vishnyakova, K. S., & Orekhov, A. N. (2022) · Biomedicines · doi:10.3390/biomedicines10040782 · Cited by 6
Agopian, J., Costa, Q. D., Nguyen, Q. V., Scorrano, G., Kousteridou, P., Yuan, M., Chelbi, R., Goubard, A., Castellano, R., Maurizio, J., et al. (2021) · Blood · doi:10.1182/blood.2020008948 · Cited by 6
Surui, A., Ulzii, D., Yadamsuren, E., & Shi, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680574 · Cited by 5
Huang, Y., Zhu, Z., Li, W., Ge, Y., Li, Y., Wang, J., Peng, X., Lin, L., Li, J., Liu, C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1171380 · Cited by 5
Salybekov, A. A., & Hassanpour, M. (2023) · Biomedicines · doi:10.3390/biomedicines11082288 · Cited by 6
Lai, J., Xi, Z., Zhu, D., Zhang, Q., Yang, Y., Wang, X., Xia, B., Hou, T., & Feng, H. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003060 · Cited by 4
Exploring the intricate cross-talk between clonal expansion and the bone marrow niche
Ngo, S. D., Papazoglou, D., Encabo, H. H., & Bonnet, D. A. (2024) · Frontiers in Hematology · doi:10.3389/frhem.2024.1334807 · Cited by 4
Swaminathan, A. C., Barfield, R., Zhang, M., Povysil, G., Chen, C., Frankel, C. W., Kelly, F. L., McKinney, M. S., Todd, J. L., Allen, A. S., et al. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02703-1 · Cited by 3
Clonal hematopoiesis of indeterminate potential: implications for the cardiologists
Sciatti, E., D’Elia, E., Gori, M., Grosu, A., Balestrieri, G., Senni, M., Barbui, T., & Gavazzi, A. (2023) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001520 · Cited by 3
The phenomenon of clonal hematopoiesis: etiology, classification and its prognostic role
Kunevich, E. O., Mikhaleva, M., Крысюк, О. Б., Bogdanov, A. N., Zherniakova, A., & Волошин, С. В. (2025) · Oncohematology · doi:10.17650/1818-8346-2025-20-1-28-54 · Cited by 2
Impact of Clonal Hematopoiesis on Solid Tumor Progression Following Radiation Therapy
Tao, J. J., Setton, J. S., Vela, P. S., Safonov, A. M., Comen, E. A., Braunstein, L. Z., Reis-Filho, J. S., Riaz, N., Powell, S. N., Levine, R. L., et al. (2025) · JCO Precision Oncology · doi:10.1200/po-24-00548 · Cited by 4
Tuning of the Hematopoietic Stem Cell Compartment in its Inflammatory Environment
Govindarajah, V., & Reynaud, D. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0131-y · Cited by 2
Yu, X., Qian, N., & Wang, Y. (2023) · Molecular Biology Reports · doi:10.1007/s11033-022-08118-1 · Cited by 2
Bataclan, M., Leoni, C., Moro, S. G., Pecoraro, M., Wong, E. H., Heissmeyer, V., & Monticelli, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.24.577016 · Cited by 2
Bueno, V. (2024) · Springer eBooks · doi:10.1007/978-3-031-55022-5_7 · Cited by 1
Clonal evolution: a landmark of MPN evolution
Maslah, N., Giraudier, S., Cassinat, B., & Kiladjian, J. (2024) · Frontiers in Hematology · doi:10.3389/frhem.2024.1473920 · Cited by 1
Li, X., Geng, X., Fan, J., Yan, F., Wang, R., Yang, Z., Li, Y., Wang, J., Luo, Y., & Zhao, H. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04699-7 · Cited by 1
Liang, C., Li, M., & Sun, Z. (2025) · Medicine · doi:10.1097/md.0000000000046608 · Cited by 1
Einfluss der klonalen Hämatopoese auf nicht-hämatologische Erkrankungen und Alterungsprozesse
Rieger, M. A. (2022) · Die Innere Medizin · doi:10.1007/s00108-022-01409-6 · Cited by 1
Age-related Disease: A Revolution Is Coming.
Bland, J. S. (2018) · Europe PMC (PubMed Central)
Unraveling clonal heterogeneity in acute myeloid leukemia
de Boer, B. (2020) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.113125010
The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases
Zhang, Z., & Sun, J. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-7471-9_5
Nani, D. A., Alvizi, L., Bueno, H. M. D. S., Lacerda, E. C. M., Yan, C. Y. I., & Passos-Bueno, M. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.27.676141
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Górska, A., van de Wetering, T., Sobalska‐Kwapis, M., Nedoszytko, B., Gutowska‐Owsiak, D., & Niedoszytko, M. (2025) · Clinical and Translational Allergy · doi:10.1002/clt2.70106
Hussain, T., Brahmbhatt, D. H., Scolari, F. L., Abelson, S., Dick, J. E., & Billia, F. (2025) · medRxiv · doi:10.1101/2025.10.28.25338307
Truby, L., Sharma, G., Watson, W. D., Halloran, P. F., Hussain, T., Madill-Thomsen, K. S., Esmailian, G., Fung, N., Peyster, E. G., Moayedi, Y., et al. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.11.008
Swaminathan, A. C., Barfield, R., Zhang, M., Povysil, G., Chen, C., Frankel, C. W., Kelly, F. L., McKinney, M., Todd, J. L., Allen, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24465055
Les propriétés immunitaires des cellules souches de la pulpe dentaire dans un contexte infectieux
Hamada, A. (2018) · theses.fr (ABES) · doi:10.70675/c8aafcebz816bz4063zb181zf9794e2577b6
Epigenetic alterations in Myeloid Malignancies
Cardoso, B. A. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_12
Yao, C., Chen, Y., Tsai, B.-R., Chen, J.-W., Chan, C., Chen, W., Lin, L.-Y., Chou, W., Ho, Y., & Yang, L. (2026) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2026.08.052
Metadata
- Authors
- Leoni, C., Montagner, S., Rinaldi, A., Bertoni, F., Polletti, S., Balestrieri, C., & Monticelli, S.
- Affiliations
- University of Bern (CH)
- Institute for Research in Biomedicine (CH)
- Institute of Oncology Research (CH)
- European Institute of Oncology (IT)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-02-06
- Volume
- 114
- Issue
- 8
- Pages
- E1490-E1499
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5338402
- OpenAlex
- W2587262629
- Cited by
- 138
- References
- 72
- Citations by year
- 2026: 2 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 19 · 2021: 16 · 2020: 20 · 2019: 13 · 2018: 11 · 2017: 6
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swiss National Science Foundation (156875, 164489)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- DNMT3A, DNA methylation, mast cells, epigenetic regulation, de novo DNA methyltransferases
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, Decitabine, DNA Methyltransferase 3A, Animals, Azacitidine, Cells, Cultured, Dermatitis, Contact, Disease Models, Animal, DNA (Cytosine-5-)-Methyltransferases, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Immunoglobulin E, Interleukin-3, Mast Cells, Mutation, Oxazolone, Passive Cutaneous Anaphylaxis, Down-Regulation, Cell Degranulation, Mice, Knockout, DNA Methylation, ras GTPase-Activating Proteins, RNA Interference, Mastocytosis, Systemic, RNA, Small Interfering, Epigenesis, Genetic, Cell Proliferation, Mice
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