Cited by 138Mast cells and histamineEpigenetics and DNA MethylationAsthma and respiratory diseases

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Dnmt3a restrains mast cell inflammatory responses

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Leoni, Cristina, Montagner, Sara, Rinaldi, Andrea, Bertoni, Francesco, Polletti, Sara, Balestrieri, Chiara, Monticelli, Silvia·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1616420114PMC PMC5338402

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Abstract

Significance Methylation of genomic DNA is an epigenetic modification at the interface between genetic information and environmental stimuli underlying many phenotypic variations in the human population as well as the pathogenesis of complex diseases. Accordingly, mutations in the de novo DNA methyltransferase enzyme DNMT3A have been identified in a number of diseases, including mast cell-related disorders. However, the role of DNA methylation and DNMT3A in regulating mast cell physiology still needs to be elucidated. Here, we found that Dnmt3a plays a critical role in modulating mast cell responsiveness to acute and chronic stimulation, potentially implicating DNA methylation-mediated processes in all types of mast cell-related diseases.

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Authors: Leoni, C., Montagner, S., Rinaldi, A., Bertoni, F., Polletti, S., Balestrieri, C., & Monticelli, S.
Affiliations: University of Bern (CH)
Institute for Research in Biomedicine (CH)
Institute of Oncology Research (CH)
European Institute of Oncology (IT)
ORCID: Leoni, Cristina
Rinaldi, Andrea
Bertoni, Francesco
Polletti, Sara
Balestrieri, Chiara
Monticelli, Silvia
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-02-06
Volume: 114
Issue: 8
Pages: E1490-E1499
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1616420114
PMC: PMC5338402
OpenAlex: W2587262629
Cited by: 138
References: 72
Citations by year: 2026: 2 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 19 · 2021: 16 · 2020: 20 · 2019: 13 · 2018: 11 · 2017: 6
FWCI: 6.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 181 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Swiss National Science Foundation (156875, 164489)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords: DNMT3A, DNA methylation, mast cells, epigenetic regulation, de novo DNA methyltransferases
MeSH terms: DNA (Cytosine-5-)-Methyltransferase 1, Decitabine, DNA Methyltransferase 3A, Animals, Azacitidine, Cells, Cultured, Dermatitis, Contact, Disease Models, Animal, DNA (Cytosine-5-)-Methyltransferases, Enzyme-Linked Immunosorbent Assay, Female, Fluorescent Antibody Technique, Immunoglobulin E, Interleukin-3, Mast Cells, Mutation, Oxazolone, Passive Cutaneous Anaphylaxis, Down-Regulation, Cell Degranulation, Mice, Knockout, DNA Methylation, ras GTPase-Activating Proteins, RNA Interference, Mastocytosis, Systemic, RNA, Small Interfering, Epigenesis, Genetic, Cell Proliferation, Mice

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Dnmt3a restrains mast cell inflammatory responses

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