The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Genetic signature of natural selection in first Americans
Abstract
Significance: There is much interest in understanding the role of natural selection in shaping physiological adaptations to climate, diet, and diseases in humans. We investigated this issue by analyzing genomic data from Native American populations inhabiting different ecological regions and ancient Native Americans. We found signals of natural selection at the fatty acid desaturases ( FADS ) genes not only in an Arctic population, as was previously found, but throughout the Americas, suggesting a single and strong adaptive event that occurred in Beringia, before the range expansion of the first Americans within the American continent and Greenland.
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“We also conclude—based on the genetic ‘arctic signal’ found throughout arctic and non-arctic First Peoples—that the ANA population on the BLB was recently derived from the Arctic, most likely the GAP/arctic Beringia (not the NE Asian maritime zone) [73,86,95].”
From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [73]
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Cites
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Ancient human genome sequence of an extinct Palaeo-Eskimo
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Cited by
Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia
Tucci, S., Vohr, S. H., McCoy, R. C., Vernot, B., Robinson, M. R., Barbieri, C., Nelson, B. J., Fu, W., Purnomo, G. A., Sudoyo, H., et al. (2018) · Science · doi:10.1126/science.aar8486 · Cited by 97
Population history and gene divergence in native Mexicans inferred from 76 human exomes
Ávila-Arcos, M. C., McManus, K. F., Sandoval, K., Rodríguez-Rodríguez, J. E., Villa-Islas, V., Martin, A. R., Luisi, P., Peñaloza-Espinosa, R. I., Eng, C., Huntsman, S., et al. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msz282 · Cited by 50
Beringia and the peopling of the Western Hemisphere
Hoffecker, J. F., Elias, S. A., Scott, G. R., O'Rourke, D. H., Hlusko, L. J., Potapova, O., Pitulko, V., Pavlova, E., Bourgeon, L., & Vachula, R. S. (2023) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2022.2246 · Cited by 17
Metadata
- Authors
- G. Amorim, C. E., Nunes, K., Meyer, D., Comas, D., Bortolini, M. C., Salzano, F. M., & Hünemeier, T.
- Affiliations
- Department of Biological Sciences, Columbia University, New York, NY 10027;
- Departmento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, 03178-200 São Paulo, Brazil;
- Institut de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain;
- Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, Brazil
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-02-13
- Volume
- 114
- Issue
- 9
- Pages
- 2195-2199
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 92
- References
- 8
- Language
- en
- Funders
- Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (PDE 201145/2015-4)
- Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (2012/09950-9)
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