The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
Inhibitory engrams in perception and memory
Open accessPublished version of a preprint
Abstract
Nervous systems use excitatory cell assemblies to encode and represent sensory percepts. Similarly, synaptically connected cell assemblies or “engrams” are thought to represent memories of past experience. Multiple lines of recent evidence indicate that brain systems create and use inhibitory replicas of excitatory representations for important cognitive functions. Such matched “inhibitory engrams” can form through homeostatic potentiation of inhibition onto postsynaptic cells that show increased levels of excitation. Inhibitory engrams can reduce behavioral responses to familiar stimuli, thereby resulting in behavioral habituation. In addition, by preventing inappropriate activation of excitatory memory engrams, inhibitory engrams can make memories quiescent, stored in a latent form that is available for context-relevant activation. In neural networks with balanced excitatory and inhibitory engrams, the release of innate responses and recall of associative memories can occur through focused disinhibition. Understanding mechanisms that regulate the formation and expression of inhibitory engrams in vivo may help not only to explain key features of cognition but also to provide insight into transdiagnostic traits associated with psychiatric conditions such as autism, schizophrenia, and posttraumatic stress disorder.
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“The recontextualized memory, in which the trauma is now located in a safer temporal and spatial context, may act as an inhibitory version of the original traumatic memory [50], which is now available to compete with the original traumatic memory.”
From Memory and Forgetting (2018) · cites this paper as [50]
Citations
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Memory engrams: Recalling the past and imagining the future
Josselyn, S. A., & Tonegawa, S. (2020) · Science · doi:10.1126/science.aaw4325 · Cited by 1,087
Beyond the Status Quo: A Role for Beta Oscillations in Endogenous Content (Re)Activation
Spitzer, B., & Haegens, S. (2017) · eNeuro · doi:10.1523/eneuro.0170-17.2017 · Cited by 667
Memory Allocation: Mechanisms and Function
Josselyn, S. A., & Frankland, P. W. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061956 · Cited by 239
Getting rid of visual distractors: the why, when, how, and where
Chelazzi, L., Marini, F., Pascucci, D., & Turatto, M. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2019.02.004 · Cited by 200
Forgetting as a form of adaptive engram cell plasticity
Ryan, T. J., & Frankland, P. W. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00548-3 · Cited by 182
Metadata
- Authors
- Barron, H. C., Vogels, T. P., Behrens, T. E., & Ramaswami, M.
- Affiliations
- University of Oxford (GB)
- Wellcome Centre for Human Neuroimaging (GB)
- Tata Institute of Fundamental Research (IN)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-06-13
- Volume
- 114
- Issue
- 26
- Pages
- 6666-6674
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5495250
- OpenAlex
- W2626706140
- Cited by
- 147
- References
- 91
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 23 · 2023: 12 · 2022: 22 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 11 · 2017: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- John Fell Fund, University of Oxford (John Fell OUP Research Fund) (153/046)
- Wellcome Trust (WT100000, WT104765MA)
- James S. McDonnell Foundation (JSMF) (JSMF220020372)
- Science Foundation Ireland (SFI) (15/IA/3123)
- Department of Atomic Energy, Government of India (DAE) (Core Funds to TIFR/NCBS)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- memory engrams, cell assemblies, habituation, latent memory, disinhibition, perception, excitation-inhibition balance, autism spectrum disorder, schizophrenia, post-traumatic stress disorder, transdiagnostic traits
- MeSH terms
- Animals, Autistic Disorder, Cognition, Humans, Memory, Models, Neurological, Nerve Net, Perception, Schizophrenia, Stress Disorders, Post-Traumatic
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