Cited by 147Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Inhibitory engrams in perception and memory

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Barron, Helen C., Vogels, Tim P., Behrens, Timothy E., Ramaswami, Mani·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1701812114PMC PMC5495250

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Abstract

Nervous systems use excitatory cell assemblies to encode and represent sensory percepts. Similarly, synaptically connected cell assemblies or “engrams” are thought to represent memories of past experience. Multiple lines of recent evidence indicate that brain systems create and use inhibitory replicas of excitatory representations for important cognitive functions. Such matched “inhibitory engrams” can form through homeostatic potentiation of inhibition onto postsynaptic cells that show increased levels of excitation. Inhibitory engrams can reduce behavioral responses to familiar stimuli, thereby resulting in behavioral habituation. In addition, by preventing inappropriate activation of excitatory memory engrams, inhibitory engrams can make memories quiescent, stored in a latent form that is available for context-relevant activation. In neural networks with balanced excitatory and inhibitory engrams, the release of innate responses and recall of associative memories can occur through focused disinhibition. Understanding mechanisms that regulate the formation and expression of inhibitory engrams in vivo may help not only to explain key features of cognition but also to provide insight into transdiagnostic traits associated with psychiatric conditions such as autism, schizophrenia, and posttraumatic stress disorder.

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Authors: Barron, H. C., Vogels, T. P., Behrens, T. E., & Ramaswami, M.
Affiliations: University of Oxford (GB)
Wellcome Centre for Human Neuroimaging (GB)
Tata Institute of Fundamental Research (IN)
ORCID: Barron, Helen C.
Vogels, Tim P.
Behrens, Timothy E.
Ramaswami, Mani
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-06-13
Volume: 114
Issue: 26
Pages: 6666-6674
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1701812114
PMC: PMC5495250
OpenAlex: W2626706140
Cited by: 147
References: 91
Citations by year: 2026: 17 · 2025: 17 · 2024: 23 · 2023: 12 · 2022: 22 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 11 · 2017: 1
FWCI: 1.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: John Fell Fund, University of Oxford (John Fell OUP Research Fund) (153/046)
Wellcome Trust (WT100000, WT104765MA)
James S. McDonnell Foundation (JSMF) (JSMF220020372)
Science Foundation Ireland (SFI) (15/IA/3123)
Department of Atomic Energy, Government of India (DAE) (Core Funds to TIFR/NCBS)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: memory engrams, cell assemblies, habituation, latent memory, disinhibition, perception, excitation-inhibition balance, autism spectrum disorder, schizophrenia, post-traumatic stress disorder, transdiagnostic traits
MeSH terms: Animals, Autistic Disorder, Cognition, Humans, Memory, Models, Neurological, Nerve Net, Perception, Schizophrenia, Stress Disorders, Post-Traumatic

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Inhibitory engrams in perception and memory

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