Cited by 664Insect and Pesticide ResearchGut microbiota and healthInsect and Arachnid Ecology and Behavior

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling

Open access

Zheng, Hao, Powell, J. Elijah, Steele, Margaret I., Dietrich, Carsten, Moran, Nancy A.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1701819114PMC PMC5422775

Open this paper in CoChat — free account Open PDF

Abstract

Social bees harbor a simple and specialized microbiota that is spatially organized into different gut compartments. Recent results on the potential involvement of bee gut communities in pathogen protection and nutritional function have drawn attention to the impact of the microbiota on bee health. However, the contributions of gut microbiota to host physiology have yet to be investigated. Here we show that the gut microbiota promotes weight gain of both whole body and the gut in individual honey bees. This effect is likely mediated by changes in host vitellogenin, insulin signaling, and gustatory response. We found that microbial metabolism markedly reduces gut pH and redox potential through the production of short-chain fatty acids and that the bacteria adjacent to the gut wall form an oxygen gradient within the intestine. The short-chain fatty acid profile contributed by dominant gut species was confirmed in vitro. Furthermore, metabolomic analyses revealed that the gut community has striking impacts on the metabolic profiles of the gut compartments and the hemolymph, suggesting that gut bacteria degrade plant polymers from pollen and that the resulting metabolites contribute to host nutrition. Our results demonstrate how microbial metabolism affects bee growth, hormonal signaling, behavior, and gut physicochemical conditions. These findings indicate that the bee gut microbiota has basic roles similar to those found in some other animals and thus provides a model in studies of host-microbe interactions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1701819114

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED ARTICLE: Increased Gut Redox and Depletion of Anaerobic and Methanogenic Prokaryotes in Severe Acute Malnutrition
Million, M., Alou, M. T., Khelaifia, S., Bachar, D., Lagier, J., Dione, N., Brah, S., Hugon, P., Lombard, V., Armougom, F., et al. (2016) · Scientific Reports · doi:10.1038/srep26051 · Cited by 204
Retracted
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions.
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Show all 85 references

Research works printed but not linked: 1

; Pollinator Health Task Force Pollinator Partnership Action Plan (The White House, Washington, DC, 2016).

Sorted by citations

Items 101–200 of 656

Modulation of the honey bee queen microbiota: Effects of early social contact
Powell, J. E., Eiri, D. M., Moran, N. A., & Rangel, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200527 · Cited by 60
Self-citation
Composition and acquisition of the microbiome in solitary, ground-nesting alkali bees
Kapheim, K. M., Johnson, M. M., & Jolley, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-82573-x · Cited by 59
The different dietary sugars modulate the composition of the gut microbiota in honeybee during overwintering
Wang, H., Liu, C., Liu, Z., Wang, Y., Ma, L., & Xu, B. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01726-6 · Cited by 59
Field-Realistic Tylosin Exposure Impacts Honey Bee Microbiota and Pathogen Susceptibility, Which Is Ameliorated by Native Gut Probiotics
Powell, J. E., Carver, Z., Leonard, S. P., & Moran, N. A. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00103-21 · Cited by 58
Self-citation
Strain-level analysis reveals the vertical microbial transmission during the life cycle of bumblebee
Su, Q., Wang, Q., Mu, X., Chen, H., Meng, Y., Zhang, X., Zheng, L., Hu, X., Zhai, Y., & Zheng, H. (2021) · Microbiome · doi:10.1186/s40168-021-01163-1 · Cited by 63
Self-citation
Field-level clothianidin exposure affects bumblebees but generally not their pathogens
Wintermantel, D., Locke, B., Andersson, G. K. S., Semberg, E., Forsgren, E., Osterman, J., Pedersen, T. R., Bommarco, R., Smith, H. G., Rundlöf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07914-3 · Cited by 65
Comparative Genomics of Wild Bee and Flower Isolated Lactobacillus Reveals Potential Adaptation to the Bee Host
Vuong, H. Q., & McFrederick, Q. S. (2019) · Genome Biology and Evolution · doi:10.1093/gbe/evz136 · Cited by 61
Modelling host–microbiome interactions in organ-on-a-chip platforms
Shin, Y. C., Than, N., Min, S., Shin, W., & Kim, H. J. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00130-9 · Cited by 58
The role of insect gut microbiota in host fitness, detoxification and nutrient supplementation
Shamjana, U., Vasu, D. A., Hembrom, P. S., Nayak, K., & Grace, T. (2024) · Antonie van Leeuwenhoek · doi:10.1007/s10482-024-01970-0 · Cited by 57
Influence of Feeding Type and Nosema ceranae Infection on the Gut Microbiota of Apis cerana Workers
Huang, S., Ye, K. T., Huang, W., Ying, B. H., Su, X., Lin, L., Li, J. H., Chen, Y. P., Li, J. L., Bao, X. L., et al. (2018) · mSystems · doi:10.1128/msystems.00177-18 · Cited by 57
Dynamics of the Honeybee (Apis mellifera) Gut Microbiota Throughout the Overwintering Period in Canada
Bleau, N., Bouslama, S., Giovenazzo, P., & Derôme, N. (2020) · Microorganisms · doi:10.3390/microorganisms8081146 · Cited by 57
Metabolic and immunological effects of gut microbiota in leaf beetles at the local and systemic levels
Ma, M., Tu, C., Luo, J., Lu, M., Zhang, S., & Xu, L. (2021) · Integrative Zoology · doi:10.1111/1749-4877.12528 · Cited by 56
Honey Bee Larval and Adult Microbiome Life Stages Are Effectively Decoupled with Vertical Transmission Overcoming Early Life Perturbations
Kowallik, V., & Mikheyev, A. S. (2021) · mBio · doi:10.1128/mbio.02966-21 · Cited by 64
The effect of carbohydrate sources: Sucrose, invert sugar and components of mānuka honey, on core bacteria in the digestive tract of adult honey bees (Apis mellifera)
Taylor, M. A., Robertson, A. W., Biggs, P. J., Richards, K. K., Jones, D. F., & Parkar, S. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225845 · Cited by 59
Nutritional and prebiotic efficacy of the microalga Arthrospira platensis (spirulina) in honey bees
Ricigliano, V. A., & Simone-Finstrom, M. D. (2020) · Apidologie · doi:10.1007/s13592-020-00770-5 · Cited by 54
Species divergence in gut-restricted bacteria of social bees
Li, Y., Leonard, S. P., Powell, J. E., & Moran, N. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115013119 · Cited by 53
Self-citation
Honeybee microbiome is stabilized in the presence of propolis
Saelao, P., Borba, R. S., Ricigliano, V. A., Spivak, M. S., & Simone-Finstrom, M. D. (2020) · Biology Letters · doi:10.1098/rsbl.2020.0003 · Cited by 53
Differential Profiles of Gut Microbiota and Metabolites Associated with Host Shift of Plutella xylostella
Yang, F., Saqib, H. S. A., Chen, J., Ruan, Q., Vasseur, L., He, W., & You, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176283 · Cited by 56
Effects on Some Therapeutical, Biochemical, and Immunological Parameters of Honey Bee (Apis mellifera) Exposed to Probiotic Treatments, in Field and Laboratory Conditions
Gajger, I. T., Vlainić, J., Šoštarić, P., Prešern, J., Bubnič, J., & Škerl, M. I. S. (2020) · Insects · doi:10.3390/insects11090638 · Cited by 53
Trypanosomatid parasite dynamically changes the transcriptome during infection and modifies honey bee physiology
Liu, Q., Lei, J., Darby, A. C., & Kadowaki, T. (2020) · Communications Biology · doi:10.1038/s42003-020-0775-x · Cited by 51
Atrazine exposure can dysregulate the immune system and increase the susceptibility against pathogens in honeybees in a dose-dependent manner
Wang, K., Cai, M., Jie, S., Chen, H., Lin, Z., Wang, Z., Niu, Q., & Ji, T. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131179 · Cited by 51
Reconstructing the functions of endosymbiotic Mollicutes in fungus-growing ants
Sapountzis, P., Zhukova, M. V., Shik, J. Z., Schiøtt, M., & Boomsma, J. J. (2018) · eLife · doi:10.7554/elife.39209 · Cited by 52
Effects of a Resident Yeast from the Honeybee Gut on Immunity, Microbiota, and Nosema Disease
Tauber, J. P., Nguyen, V., Lopez, D., & Evans, J. D. (2019) · Insects · doi:10.3390/insects10090296 · Cited by 50
Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria
Yao, Z., Cai, Z., Ma, Q., Bai, S., Wang, Y., Zhang, P., Guo, Q., Gu, J., Lemaître, B., & Zhang, H. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111523 · Cited by 49
Microbiome assembly and maintenance across the lifespan of bumble bee workers
Hammer, T. J., Easton‐Calabria, A., & Moran, N. A. (2022) · Molecular Ecology · doi:10.1111/mec.16769 · Cited by 51
Self-citation
Insect symbionts as valuable grist for the biotechnological mill: an alkaliphilic silkworm gut bacterium for efficient lactic acid production
Liang, X., Sun, C., Chen, B., Du, K., Yu, T. Y., Luang‐In, V., Lu, X., & Shao, Y. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-8953-1 · Cited by 49
Mineral and organic fertilization alters the microbiome of a soil nematode Dorylaimus stagnalis and its resistome
Zheng, F., Zhu, D., Giles, M. E., Daniell, T. J., Neilson, R., Zhu, Y., & Yang, X. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.04.384 · Cited by 49
Inter- and Intra-Species Diversity of Lactic Acid Bacteria in Apis mellifera ligustica Colonies
Iorizzo, M., Pannella, G., Lombardi, S. J., Ganassi, S., Testa, B., Succi, M., Sorrentino, E., Petrarca, S., Cristofaro, A. D., Coppola, R., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8101578 · Cited by 49
Gut symbiotic bacteria are involved in nitrogen recycling in the tephritid fruit fly Bactrocera dorsalis
Ren, X., Cao, S., Akami, M., Mansour, A., Yang, Y., Jiang, N., Wang, H., Zhang, G., Qi, X., Xu, P., et al. (2022) · BMC Biology · doi:10.1186/s12915-022-01399-9 · Cited by 48
Honeybee (Apis mellifera) resistance to deltamethrin exposure by Modulating the gut microbiota and improving immunity
Dong, Z., Tang, Q. H., Li, W.-L., Wang, Z., Li, X., Fu, C.-M., Li, D., Qian, K., Tian, W., & Guo, J. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120340 · Cited by 48
Honeybee-Specific Lactic Acid Bacterium Supplements Have No Effect on American Foulbrood-Infected Honeybee Colonies
Stephan, J. G., Lamei, S., Pettis, J. S., Riesbeck, K., de Miranda, J. R., & Forsgren, E. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00606-19 · Cited by 48
The effects of glyphosate, pure or in herbicide formulation, on bumble bees and their gut microbial communities
Motta, E. V. S., & Moran, N. A. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.162102 · Cited by 46
Self-citation
Conspecific coprophagy stimulates normal development in a germ-free model invertebrate
Jahnes, B. C., Herrmann, M., & Sabree, Z. L. (2019) · PeerJ · doi:10.7717/peerj.6914 · Cited by 46
Antimicrobial Activity against Paenibacillus larvae and Functional Properties of Lactiplantibacillus plantarum Strains: Potential Benefits for Honeybee Health
Iorizzo, M., Testa, B., Lombardi, S. J., Ganassi, S., Ianiro, M., Letizia, F., Succi, M., Tremonte, P., Vergalito, F., Cozzolino, A., et al. (2020) · Antibiotics · doi:10.3390/antibiotics9080442 · Cited by 46
Deep Divergence and Genomic Diversification of Gut Symbionts of Neotropical Stingless Bees
Sarton-Lohéac, G., Nunes-Silva, C. G., Mazel, F., Baud, G., de Bakker, V., Das, S., Chazli, Y. E., Ellegaard, K., Garcia‐Garcerà, M., Glover, N., et al. (2023) · mBio · doi:10.1128/mbio.03538-22 · Cited by 45
Microplastics and Nanoplastics Effects on Plant–Pollinator Interaction and Pollination Biology
Shah, S., Ilyas, M., Li, R., Yang, J., & Yang, F. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.2c07733 · Cited by 47
Effects of Phytoestrogens on the Developing Brain, Gut Microbiota, and Risk for Neurobehavioral Disorders
Rosenfeld, C. S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00142 · Cited by 46
Temperature dependence of parasitic infection and gut bacterial communities in bumble bees
Palmer‐Young, E. C., Ngor, L., Nevarez, R. B., Rothman, J. A., Raffel, T. R., & McFrederick, Q. S. (2019) · Environmental Microbiology · doi:10.1111/1462-2920.14805 · Cited by 45
Animal-Microbe Interactions in the Context of Diapause
Mushegian, A. A., & Tougeron, K. (2019) · Biological Bulletin · doi:10.1086/706078 · Cited by 44
The impact of winter feed type on intestinal microbiota and parasites in honey bees
D’Alvise, P., Böhme, F., Codrea, M. C., Seitz, A., Nahnsen, S., Binzer, M., Rosenkranz, P., & Hasselmann, M. (2017) · Apidologie · doi:10.1007/s13592-017-0551-1 · Cited by 44
Genome Sequences of Apibacter spp., Gut Symbionts of Asian Honey Bees
Kwong, W. K., Steele, M. I., & Moran, N. A. (2018) · Genome Biology and Evolution · doi:10.1093/gbe/evy076 · Cited by 44
Self-citation
A system biology perspective on environment–host–microbe interactions
Chen, L., Garmaeva, S., Zhernakova, A., Fu, J., & Wijmenga, C. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy137 · Cited by 47
Host-microbiome metabolism of a plant toxin in bees
Motta, E. V. S., Gage, A., Smith, T. E., Blake, K. J., Kwong, W. K., Riddington, I. M., & Moran, N. A. (2022) · eLife · doi:10.7554/elife.82595 · Cited by 49
Self-citation
Eco-friendly O-carboxymethyl chitosan base chlorfenapyr nanopesticide for effective pest control and reduced toxicity to honey bees
Hou, R., Li, C., Tan, Y., Wang, Y., Huang, S., Zhao, C., & Zhang, Z. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.182 · Cited by 43
PGRP-LB homolog acts as a negative modulator of immunity in maintaining the gut-microbe symbiosis of red palm weevil, Rhynchophorus ferrugineus Olivier
Dawadi, B., Wang, X., Xiao, R., Muhammad, A., Hou, Y., & Shi, Z. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.04.021 · Cited by 43
Peptide Hormones in the Insect Midgut
Wu, K. C., Li, S., Wang, J., Ni, Y., Huang, W., Liu, Q., & Ling, E. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00191 · Cited by 45
When your host shuts down: larval diapause impacts host-microbiome interactions in Nasonia vitripennis
Dittmer, J., & Brucker, R. M. (2021) · Microbiome · doi:10.1186/s40168-021-01037-6 · Cited by 42
Chronic Exposure to Polystyrene Microplastic Fragments Has No Effect on Honey Bee Survival, but Reduces Feeding Rate and Body Weight
Naggar, Y. A., Sayes, C. M., Collom, C., Ayorinde, T., Qi, S., El-Seedi, H. R., Paxton, R. J., & Wang, K. (2023) · Toxics · doi:10.3390/toxics11020100 · Cited by 44
The plant-sucking insect selects assembly of the gut microbiota from environment to enhance host reproduction
Shan, H., Xia, X., Feng, Y.-L., Wu, W., Li, H., Sun, Z., Li, J., & Chen, J.-P. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00539-z · Cited by 42
pH/Enzyme-responsive nanocarrier pesticide delivery system: Realizing targeted release in pest gut for enhanced Apis cerana safety
Du, P., Shao, X., Wu, H., Hou, R., Liu, J., Chang, J., Miao, X., Wang, X., Liu, P., Zhu, S., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158419 · Cited by 42
Longitudinal Effects of Supplemental Forage on the Honey Bee (Apis mellifera) Microbiota and Inter- and Intra-Colony Variability
Rothman, J. A., Carroll, M. J., Meikle, W. G., Anderson, K. E., & McFrederick, Q. S. (2018) · Microbial Ecology · doi:10.1007/s00248-018-1151-y · Cited by 45
Pollen reverses decreased lifespan, altered nutritional metabolism, and suppressed immunity in honey bees ( Apis mellifera ) treated with antibiotics
Li, J., Heerman, M. C., Evans, J. D., Rose, R., Li, W., Rodríguez-García, C., DeGrandi‐Hoffman, G., Zhao, Y., Huang, S., Li, Z., et al. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.202077 · Cited by 42
Social Interaction is Unnecessary for Hindgut Microbiome Transmission in Honey Bees: The Effect of Diet and Social Exposure on Tissue-Specific Microbiome Assembly
Anderson, K. E., Ricigliano, V. A., Copeland, D. C., Mott, B. M., & Maes, P. W. (2022) · Microbial Ecology · doi:10.1007/s00248-022-02025-5 · Cited by 42
Carpenter Bees ( Xylocopa ) Harbor a Distinctive Gut Microbiome Related to That of Honey Bees and Bumble Bees
Holley, J.-A. C., Jackson, M. N., Pham, A. T., Hatcher, S. C., & Moran, N. A. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.00203-22 · Cited by 41
Self-citation
Investigating the effects of glyphosate on the bumblebee proteome and microbiota
Cullen, M. G., Bliss, L., Stanley, D. A., & Carolan, J. C. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.161074 · Cited by 41
Unlocking the power of short-chain fatty acids in ameliorating intestinal mucosal immunity: a new porcine nutritional approach
Liu, H., Lu, H., Wang, Y., yu, C., He, Z., & Dong, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1449030 · Cited by 41
The multifaceted roles of gut microbiota in insect physiology, metabolism, and environmental adaptation: implications for pest management strategies
Haider, K., Abbas, D., Galián, J., Ghafar, M. A., Kabir, K., Ijaz, M. H., Hussain, M., Khan, K. A., Ghramh, H. A., & Raza, A. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04288-9 · Cited by 43
Genetic divergence and functional convergence of gut bacteria between the Eastern honey bee Apis cerana and the Western honey bee Apis mellifera
Wu, Y., Zheng, Y., Wang, S., Chen, Y., Tao, J., Chen, Y., Chen, G., Zhao, H., Wang, K., Dong, K., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.08.002 · Cited by 40
Self-citation
Why Did the Bee Eat the Chicken? Symbiont Gain, Loss, and Retention in the Vulture Bee Microbiome
Figueroa, L. L., Maccaro, J. J., Krichilsky, E., Yanega, D., & McFrederick, Q. S. (2021) · mBio · doi:10.1128/mbio.02317-21 · Cited by 40
Axenic and gnotobiotic insect technologies in research on host–microbiota interactions
Wu, J., Wang, Q., Wang, D., Wong, A. C.-N., & Wang, G.-H. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.02.007 · Cited by 40
Thiacloprid impairs honeybee worker learning and memory with inducing neuronal apoptosis and downregulating memory-related genes
Li, A., Yin, L., Li, K., Diao, Q., Wu, Y., Dai, P., & Liu, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163820 · Cited by 40
Bee products: An overview of sources, biological activities and advanced approaches used in apitherapy application
El-Didamony, S. E., Gouda, H. I. A.-A., Zidan, M. M. M., & Amer, R. I. (2024) · Biotechnology Reports · doi:10.1016/j.btre.2024.e00862 · Cited by 40
A Pediococcus strain to rescue honeybees by decreasing Nosema ceranae- and pesticide-induced adverse effects
Peghaire, E., Moné, A., Delbac, F., Debroas, D., Chaucheyras‐Durand, F., & Alaoui, H. E. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.11.006 · Cited by 40
Apis ceranagut microbiota contribute to host health though stimulating host immune system and strengthening host resistance toNosema ceranae
Wu, Y., Zheng, Y., Chen, Y., Chen, G., Zheng, H., & Hu, F. (2020) · Royal Society Open Science · doi:10.1098/rsos.192100 · Cited by 40
Self-citation
Microbial Diversity in Bee Species and Bee Products: Pseudomonads Contribution to Bee Well-Being and the Biological Activity Exerted by Honey Bee Products: A Narrative Review
Tsadila, C., Amoroso, C., & Mossialos, D. (2023) · Diversity · doi:10.3390/d15101088 · Cited by 37
Crosstalk between the microbiota and insect postembryonic development
Girard, M., Luis, P., Moro, C. V., & Minard, G. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.08.013 · Cited by 37
Strategies and techniques to mitigate the negative impacts of pesticide exposure to honey bees
Zhang, G., Olsson, R. L., & Hopkins, B. K. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120915 · Cited by 37
Apilactobacillus apisilvae sp. nov., Nicolia spurrieriana gen. nov. sp. nov., Bombilactobacillus folatiphilus sp. nov. and Bombilactobacillus thymidiniphilus sp. nov., four new lactic acid bacterial isolates from stingless bees Tetragonula carbonaria and Austroplebeia australis
Oliphant, S. A., Watson‐Haigh, N. S., Sumby, K. M., Gardner, J. M., Groom, S. V. C., & Jiranek, V. (2022) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.005588 · Cited by 36
The sulfoximine insecticide sulfoxaflor exposure reduces the survival status and disrupts the intestinal metabolism of the honeybee Apis mellifera
Cheng, S., Dai, P., Li, R., Chen, Z., Liang, P., Xie, X., Zhen, C., & Gao, X. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130109 · Cited by 36
Behavior and gut bacteria of Partamona helleri under sublethal exposure to a bioinsecticide and a leaf fertilizer
Botina, L. L., Vélez-Ruiz, M. C., Barbosa, W. F., Mendonça, A. C., Pylro, V. S., Tótola, M. R., & Martins, G. F. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.06.048 · Cited by 36
Why Evolve Reliance on the Microbiome for Timing of Ontogeny?
Metcalf, C. J. E., Henry, L. P., Rebolleda‐Gómez, M., & Koskella, B. L. (2019) · mBio · doi:10.1128/mbio.01496-19 · Cited by 36
Evolution of Interbacterial Antagonism in Bee Gut Microbiota Reflects Host and Symbiont Diversification
Steele, M. I., & Moran, N. A. (2021) · mSystems · doi:10.1128/msystems.00063-21 · Cited by 36
Self-citation
Recent Advances in the Biocontrol of Nosemosis in Honey Bees (Apis mellifera L.)
Iorizzo, M., Letizia, F., Ganassi, S., Testa, B., Petrarca, S., Albanese, G., Criscio, D. D., & Cristofaro, A. D. (2022) · Journal of Fungi · doi:10.3390/jof8050424 · Cited by 36
The microbiome and gene expression of honey bee workers are affected by a diet containing pollen substitutes
Powell, J. E., Lau, P., Rangel, J., Arnott, R., Jong, T. D., & Moran, N. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286070 · Cited by 35
Self-citation
Spätzle Homolog-Mediated Toll-Like Pathway Regulates Innate Immune Responses to Maintain the Homeostasis of Gut Microbiota in the Red Palm Weevil, Rhynchophorus ferrugineus Olivier (Coleoptera: Dryophthoridae)
Muhammad, A., Habineza, P., Wang, X., Xiao, R., Ji, T., Hou, Y., & Shi, Z. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00846 · Cited by 35
Chronic High Glyphosate Exposure Delays Individual Worker Bee (Apis mellifera L.) Development under Field Conditions
Odemer, R., Alkassab, A. T., Bischoff, G., Frommberger, M., Wernecke, A., Wirtz, I., Pistorius, J., & Odemer, F. (2020) · Insects · doi:10.3390/insects11100664 · Cited by 35
Microbiota dysbiosis in honeybee ( Apis mellifera L . ) larvae infected with brood diseases and foraging bees exposed to agrochemicals
Ye, M., Fan, S., Li, X.-Y., Tarequl, I. M., Yan, C.-X., Wei, W., Yang, S., & Zhou, B. (2021) · Royal Society Open Science · doi:10.1098/rsos.201805 · Cited by 35
Overwintering Honey Bee Colonies: Effect of Worker Age and Climate on the Hindgut Microbiota
Maes, P. W., Floyd, A. S., Mott, B. M., & Anderson, K. E. (2021) · Insects · doi:10.3390/insects12030224 · Cited by 35
The Succession of the Gut Microbiota in Insects: A Dynamic Alteration of the Gut Microbiota During the Whole Life Cycle of Honey Bees (Apis cerana)
Dong, Z., Chen, Y., Li, H.-Y., Tang, Q., & Guo, J. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.513962 · Cited by 38
Research Progresses on the Function and Detection Methods of Insect Gut Microbes
Li, Y., Chang, L., Xu, K., Zhang, S., Gao, F., & Fan, Y. (2023) · Microorganisms · doi:10.3390/microorganisms11051208 · Cited by 34
Temperature-mediated inhibition of a bumblebee parasite by an intestinal symbiont
Palmer‐Young, E. C., Raffel, T. R., & McFrederick, Q. S. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.2041 · Cited by 36
Bacillus symbiont drives alterations in intestinal microbiota and circulating metabolites of lepidopteran host
Li, G., Zheng, X., Zhu, Y., Long, Y., & Xia, X. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.15934 · Cited by 34
Midgut microbiota diversity of potato tuber moth associated with potato tissue consumed
Zheng, Y., Xiao, G., Zhou, W., Gao, Y., ZhengYue, L., Du, G., & Chen, B. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01740-8 · Cited by 34
Neuroactive metabolites modulated by the gut microbiota in honey bees
Cabirol, A., Moriano‐Gutierrez, S., & Engel, P. (2023) · Molecular Microbiology · doi:10.1111/mmi.15167 · Cited by 36
Placental Microbial Colonization and Its Association With Pre-eclampsia
Olaniyi, K. S., Moodley, J., Mahabeer, Y., & Mackraj, I. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00413 · Cited by 36
Antibiotic Treatment Decrease the Fitness of Honeybee (Apis mellifera) Larvae
Duan, X., Zhao, B., Jin, X., Cheng, X., Huang, S., & Li, J. (2021) · Insects · doi:10.3390/insects12040301 · Cited by 33
Bumblebees with the socially transmitted microbiome: A novel model organism for gut microbiota research
Zhang, Z., & Zheng, H. (2022) · Insect Science · doi:10.1111/1744-7917.13040 · Cited by 33
Self-citation
Significant compositional and functional variation reveals the patterns of gut microbiota evolution among the widespread Asian honeybee populations
Su, Q., Tang, M., Hu, J., Tang, J., Zhang, X., Li, X., Niu, Q., Zhou, X. J., Luo, S., & Zhou, X. Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.934459 · Cited by 34
Glyphosate and a glyphosate-based herbicide affect bumblebee gut microbiota
Helander, M. L., Jeevannavar, A., Kaakinen, K., Mathew, S. A., Saikkonen, K., Fuchs, B., Puigbò, P., Loukola, O., & Tamminen, M. V. (2023) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiad065 · Cited by 32
Low-density polyethylene enhances the disturbance of microbiome and antibiotic resistance genes transfer in soil-earthworm system induced by pyraclostrobin
Zhang, Y., Qin, K., & Liu, C. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133459 · Cited by 32
Prospects of probiotics in beekeeping: a review for sustainable approach to boost honeybee health
Smriti, Rana, A., Singh, G., & Gupta, G. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-03926-4 · Cited by 32
Evolution of satellite plasmids can prolong the maintenance of newly acquired accessory genes in bacteria
Zhang, X., Deatherage, D. E., Zheng, H., Georgoulis, S. J., & Barrick, J. E. (2019) · Nature Communications · doi:10.1038/s41467-019-13709-x · Cited by 32
Self-citation
Effect of Nosema ceranae infection and season on the gut bacteriome composition of the European honeybee (Apis mellifera)
Jabal‐Uriel, C., Alba, C., Higes, M., Rodríguez, J. M., & Martín‐Hernández, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-13337-4 · Cited by 33
Basic Structures of Gut Bacterial Communities in Eusocial Insects
Suenami, S., Koto, A., & Miyazaki, R. (2023) · Insects · doi:10.3390/insects14050444 · Cited by 32
Synergies Between Division of Labor and Gut Microbiomes of Social Insects
Sinotte, V. M., Renelies‐Hamilton, J., Taylor, B. A., Ellegaard, K., Sapountzis, P., Vasseur-Cognet, M., & Poulsen, M. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2019.00503 · Cited by 32
Gut microbial community response to herbicide exposure in a ground beetle
Giglio, A., Vommaro, M. L., Gionechetti, F., & Pallavicini, A. (2021) · Journal of Applied Entomology · doi:10.1111/jen.12919 · Cited by 31
Early Queen Development in Honey Bees: Social Context and Queen Breeder Source Affect Gut Microbiota and Associated Metabolism
Copeland, D. C., Anderson, K. E., & Mott, B. M. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00383-22 · Cited by 31
Changes in gut microbiota and metabolism associated with phenotypic plasticity in the honey bee Apis mellifera
Copeland, D. C., Maes, P. W., Mott, B. M., & Anderson, K. E. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1059001 · Cited by 31
Probing the Honey Bee Diet-Microbiota-Host Axis Using Pollen Restriction and Organic Acid Feeding
Ricigliano, V. A., & Anderson, K. E. (2020) · Insects · doi:10.3390/insects11050291 · Cited by 31
High-Fat Diets with Differential Fatty Acids Induce Obesity and Perturb Gut Microbiota in Honey Bee
Wang, X., Zhong, Z., Chen, X., Hong, Z., Lin, W., Mu, X., Hu, X., & Zheng, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020834 · Cited by 33
Self-citation

Authors: Zheng, H., Powell, J. E., Steele, M. I., Dietrich, C., & Moran, N. A.
Affiliations: The University of Texas at Austin (US)
Siemens Healthineers (Germany) (DE)
ORCID: Zheng, Hao
Powell, J. Elijah
Steele, Margaret I.
Moran, Nancy A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-04-18
Volume: 114
Issue: 18
Pages: 4775-4780
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1701819114
PMC: PMC5422775
OpenAlex: W2605691951
Cited by: 664
References: 85
Citations by year: 2026: 63 · 2025: 75 · 2024: 91 · 2023: 74 · 2022: 91 · 2021: 83 · 2020: 74 · 2019: 45 · 2018: 59 · 2017: 9
FWCI: 47.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | National Institutes of Health (1R01-GM108477-01)
DOD | Defense Advanced Research Projects Agency (HR0011-15-C-0095)
Topics: Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Pesticide Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Arachnid Ecology and Behavior
Keywords: honey bee gut microbiota, short-chain fatty acids, gut pH, redox potential, oxygen gradients, insulin signaling, vitellogenin, gustatory response, host-microbe interactions, bee nutrition
MeSH terms: Gastrointestinal Microbiome, Animals, Bacteria, Bees, Body Weight, Insect Hormones, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks