Cited by 664Insect and Pesticide ResearchGut microbiota and healthInsect and Arachnid Ecology and Behavior

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Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling

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Zheng, Hao, Powell, J. Elijah, Steele, Margaret I., Dietrich, Carsten, Moran, Nancy A.·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1701819114PMC PMC5422775

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Abstract

Social bees harbor a simple and specialized microbiota that is spatially organized into different gut compartments. Recent results on the potential involvement of bee gut communities in pathogen protection and nutritional function have drawn attention to the impact of the microbiota on bee health. However, the contributions of gut microbiota to host physiology have yet to be investigated. Here we show that the gut microbiota promotes weight gain of both whole body and the gut in individual honey bees. This effect is likely mediated by changes in host vitellogenin, insulin signaling, and gustatory response. We found that microbial metabolism markedly reduces gut pH and redox potential through the production of short-chain fatty acids and that the bacteria adjacent to the gut wall form an oxygen gradient within the intestine. The short-chain fatty acid profile contributed by dominant gut species was confirmed in vitro. Furthermore, metabolomic analyses revealed that the gut community has striking impacts on the metabolic profiles of the gut compartments and the hemolymph, suggesting that gut bacteria degrade plant polymers from pollen and that the resulting metabolites contribute to host nutrition. Our results demonstrate how microbial metabolism affects bee growth, hormonal signaling, behavior, and gut physicochemical conditions. These findings indicate that the bee gut microbiota has basic roles similar to those found in some other animals and thus provides a model in studies of host-microbe interactions.

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Authors: Zheng, H., Powell, J. E., Steele, M. I., Dietrich, C., & Moran, N. A.
Affiliations: The University of Texas at Austin (US)
Siemens Healthineers (Germany) (DE)
ORCID: Zheng, Hao
Powell, J. Elijah
Steele, Margaret I.
Moran, Nancy A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2017-04-18
Volume: 114
Issue: 18
Pages: 4775-4780
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1701819114
PMC: PMC5422775
OpenAlex: W2605691951
Cited by: 664
References: 85
Citations by year: 2026: 63 · 2025: 75 · 2024: 91 · 2023: 74 · 2022: 91 · 2021: 83 · 2020: 74 · 2019: 45 · 2018: 59 · 2017: 9
FWCI: 47.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 183 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | National Institutes of Health (1R01-GM108477-01)
DOD | Defense Advanced Research Projects Agency (HR0011-15-C-0095)
Topics: Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Pesticide Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Arachnid Ecology and Behavior
Keywords: honey bee gut microbiota, short-chain fatty acids, gut pH, redox potential, oxygen gradients, insulin signaling, vitellogenin, gustatory response, host-microbe interactions, bee nutrition
MeSH terms: Gastrointestinal Microbiome, Animals, Bacteria, Bees, Body Weight, Insect Hormones, Signal Transduction

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Honeybee gut microbiota promotes host weight gain via bacterial metabolism and hormonal signaling

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