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A genomewide survey of basic helix–loop–helix factors in Drosophila
Open accessAbstract
The basic helix–loop–helix (bHLH) transcription factors play important roles in the specification of tissue type during the development of animals. We have used the information contained in the recently published genomic sequence of Drosophila melanogaster to identify 12 additional bHLH proteins. By sequence analysis we have assigned these proteins to families defined by Atonal, Hairy-Enhancer of Split, Hand, p48, Mesp, MYC/USF, and the bHLH-Per, Arnt, Sim (PAS) domain. In addition, one single protein represents a unique family of bHLH proteins. mRNA in situ analysis demonstrates that the genes encoding these proteins are expressed in several tissue types but are particularly concentrated in the developing nervous system and mesoderm.
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Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698
Zhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789
Myogenesis: A View from Drosophila
Baylies, M. K., Bate, M., & Gomez, M. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81198-8 · Cited by 274
Cited by
Novitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615
The Basic Helix-Loop-Helix Protein Family: Comparative Genomics and Phylogenetic Analysis
Ledent, V., & Vervoort, M. (2001) · Genome Research · doi:10.1101/gr.177001 · Cited by 458
Drosophila Met and Gce are partially redundant in transducing juvenile hormone action
Abdou, M. A., He, Q., Wen, D., Zyaan, O., Wang, J., Xu, J., Baumann, A. A., Joseph, J., Wilson, T. G., Li, S., et al. (2011) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2011.09.003 · Cited by 183
Metadata
- Authors
- Moore, A. W., Barbel, S., Jan, L. Y., & Jan, Y. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-09-05
- Volume
- 97
- Issue
- 19
- Pages
- 10436-10441
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059429906
- Cited by
- 177
- References
- 4
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Moore, A. W., Barbel, S., Jan, L. Y., & Jan, Y. N. (2000). A genomewide survey of basic helix–loop–helix factors in Drosophila. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.170301897
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