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Novel Pyrrolo[3,2- d ]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

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A review of small-molecule inhibitors of one-carbon enzymes: SHMT2 and MTHFD2 in the spotlight

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Refining Classification of Cholangiocarcinoma Subtypes via Proteogenomic Integration Reveals New Therapeutic Prospects

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Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases

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SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells

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Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses

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MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1

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Metabolic Reprogramming in Hematologic Malignancies: Advances and Clinical Perspectives

Yu, Z., Zhou, X., & Wang, X. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0917 · Cited by 42

Metastasis organotropism in colorectal cancer: advancing toward innovative therapies

He, K., Wang, Z., Luo, M., Li, B., Ding, N., Li, L., He, B., Wang, H., Cao, J., Huang, C., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04460-5 · Cited by 45

Metabolome analysis reveals excessive glycolysis via PI3K/AKT/mTOR and RAS/MAPK signaling in methotrexate-resistant primary CNS lymphoma-derived cells

Takashima, Y., Hayano, A., & Yamanaka, R. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3851 · Cited by 39

Cellular pharmacodynamics of a novel pyrrolo­[3,2-d]­pyrimidine inhibitor targeting mitochondrial and cytosolic one-carbon metabolism

Dekhne, A. S., Ning, C., Nayeen, M. J., Shah, K., Kalpage, H., Frühauf, J., Wallace-Povirk, A., O’Connor, C., Hou, Z., Kim, S., et al. (2020) · Molecular Pharmacology · doi:10.1124/mol.119.117937 · Cited by 40

SHMT2 regulates esophageal cancer cell progression and immune Escape by mediating m6A modification of c-myc

Qiao, Z., Li, Y., Cheng, Y., Li, S., & Liu, S. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01148-7 · Cited by 40

Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury

Du, C., Liu, C., Yu, K., Zhang, S., Fu, Z., Chen, X., Liao, W., Chen, J., Zhang, Y., Wang, X., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.07.009 · Cited by 42

The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells

Giardina, G., Paone, A., Tramonti, A., Lucchi, R., Marani, M., Magnifico, M. C., Bouzidi, A., Pontecorvi, V., Guiducci, G., Zamparelli, C., et al. (2018) · FEBS Journal · doi:10.1111/febs.14610 · Cited by 39

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Ramos, L., Henriksson, M., Helleday, T., & Green, A. C. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1290 · Cited by 38

Target enzymes in serine‐glycine‐one‐carbon metabolic pathway for cancer therapy

Sun, W. Y., Zhao, E., & Cui, H. (2022) · International Journal of Cancer · doi:10.1002/ijc.34353 · Cited by 39

Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties

Tramonti, A., Nardella, C., di Salvo, M. L., Barile, A., Cutruzzolà, F., & Contestabile, R. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b01074 · Cited by 37

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

Makino, Y., Oe, C., Iwama, K., Suzuki, S., Nishiyama, A., Hasegawa, K., Okuda, H., Hirata, K., Ueno, M., Kawaji, K., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03555-x · Cited by 36

Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders

Serpa, J. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_1 · Cited by 35

The Metabolomic Profile of Lymphoma Subtypes: A Pilot Study

Barberini, L., Noto, A., Fattuoni, C., Satta, G., Zucca, M., Cabras, M. G., Mura, E., & Cocco, P. (2019) · Molecules · doi:10.3390/molecules24132367 · Cited by 34

Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas

Martins, F., Gonçalves, L. G., Pojo, M., & Serpa, J. (2020) · Biomolecules · doi:10.3390/biom10101370 · Cited by 35

Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

Cuyàs, E., Fernández‐Arroyo, S., Buxó, M., Pernas, S., Dorca, J., Álvarez, I., Torres‐Martínez, S., Pérez-García, J. M., Batista-López, N., Rodríguez‐Sánchez, C. A., et al. (2019) · Aging · doi:10.18632/aging.101960 · Cited by 33

Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning

He, L., Bao, J., Yang, Y., Dong, S., Zhang, L., Qi, Y., & Zhang, J. Z. H. (2019) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.9b00370 · Cited by 33

Metformin Is a Pyridoxal-5′-phosphate (PLP)-Competitive Inhibitor of SHMT2

Tramonti, A., Cuyàs, E., Encinar, J. A., Pietzke, M., Paone, A., Verdura, S., Arbusà, A., Martı́n-Castillo, B., Giardina, G., Joven, J., et al. (2021) · Cancers · doi:10.3390/cancers13164009 · Cited by 31

One-carbon metabolism shapes T cell immunity in cancer

Qiu, Y., Xie, E., Xu, H., Cheng, H., & Li, G. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.05.010 · Cited by 33

Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond

Franco, C. N., Seabrook, L. J., Nguyen, S. T., Leonard, J. T., & Albrecht, L. V. (2022) · Metabolites · doi:10.3390/metabo12100961 · Cited by 36

Targeting one‐carbon metabolism for cancer immunotherapy

Ren, X., Wang, X., Zheng, G., Wang, S., Wang, Q., Yuan, M., Xu, T., Xu, J., Huang, P. C., & Ge, M. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1521 · Cited by 34

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

Gu, C., Liu, J., Liu, X., Zhang, H., Luo, J., Wang, H., Locasale, J. W., & Shears, S. B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020187118 · Cited by 31

Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer

Lee, H. M., Muhammad, N., Lieu, E. L., Cai, F., Mu, J., Ha, Y., Cao, G., Suchors, C., Joves, K., Chronis, C., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01066-z · Cited by 33

The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment

Zhou, X., Tian, C., Cao, Y., Zhao, M., & Wang, K. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2022.1084609 · Cited by 32

ERRα activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption

Li, X., Zhang, K., Hu, Y., & Luo, N. (2020) · Bioscience Reports · doi:10.1042/bsr20192465 · Cited by 29

Epigenetic, Metabolic, and Immune Crosstalk in Germinal-Center-Derived B-Cell Lymphomas: Unveiling New Vulnerabilities for Rational Combination Therapies

Serganova, I. S., Chakraborty, S., Yamshon, S., Isshiki, Y., Bucktrout, R., Melnick, A. M., Béguelin, W., & Zappasodi, R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.805195 · Cited by 30

Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors

Schneider, M. J., O’Connor, C. E., Bao, X., Nayeen, M. J., Magdum, T., Sharma, A., Li, J., Kim, S., Dann, C. E., Gangjee, A., et al. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100120 · Cited by 2

Abstract 3516: Discovery of novel SHMT small molecule inhibitors for cancer treatment

Bartosik, A. R., Guzik, P., Sowińska, M., Gluza, K., Król, M., Wróbel, A., Dreas, A., Iwanska, F., Zastawna, M., Kulesza, U., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-3516 · Cited by 2

Abstract 4903: Levels of folate transporters impact the compartmentalization of one-carbon metabolism in the mitochondria vs cytosol providing a unique vulnerability to SHMT inhibition

Schneider, M. J., O’Connor, C. E., Bao, X., Nayeen, M. J., Hou, Z., Li, J., Gangjee, A., & Matherly, L. H. (2023) · Cancer Research · doi:10.1158/1538-7445.am2023-4903

Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability

Lee, W. D., Pirona, A. C., Sarvin, B. A., Stern, A., Nevo‐Dinur, K., Besser, E., Sarvin, N., Lagziel, S., Mukha, D., Raz, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.002 · Cited by 67

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

García‐Cañaveras, J. C., Lancho, O., Ducker, G. S., Ghergurovich, J. M., Xu, X., da Silva-Diz, V., Minuzzo, S. A., Indraccolo, S., Kim, H., Herranz, D., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0845-6 · Cited by 129