The Diverse Functions of Non-Essential Amino Acids in Cancer

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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Serine, glycine and one-carbon units: cancer metabolism in full circle

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

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An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

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Glutamine and cancer: cell biology, physiology, and clinical opportunities

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CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

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Quantitative flux analysis reveals folate-dependent NADPH production

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Recommendations on the Use of 18 F-FDG PET in Oncology

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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

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Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

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Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

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Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

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Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

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An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

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NRF2 regulates serine biosynthesis in non–small cell lung cancer

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Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

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Cancer related mutations in <i>NRF2</i> impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

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Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?

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Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

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Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis

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Serine is an essential metabolite for effector T cell expansion

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

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Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells

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The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

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Modulating the therapeutic response of tumours to dietary serine and glycine starvation

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Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

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Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

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Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

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A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

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Asparagine bioavailability governs metastasis in a model of breast cancer

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One-carbon metabolism in cancer

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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

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Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

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Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs

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Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

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One‐carbon metabolism and epigenetics: understanding the specificity

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Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

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Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

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Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

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Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

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Transport of Amino Acid-Related Compounds Mediated by L-Type Amino Acid Transporter 1 (LAT1): Insights Into the Mechanisms of Substrate Recognition

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Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway

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Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

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Improving the metabolic fidelity of cancer models with a physiological cell culture medium

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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

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ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

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Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

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Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

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