Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

Xiao, Qi; Sherman, Samuel E.; Wilner, Samantha E.; Zhou, Xuhao; Dazen, Cody; Baumgart, Tobias; Reed, Ellen H.; Hammer, Daniel A.; Shinoda, Wataru; Klein, Michael L.; Percec, Virgil

doi:10.1073/pnas.1708380114

Cited by 170

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

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Xiao, Qi, Sherman, Samuel E., Wilner, Samantha E., Zhou, Xuhao, Dazen, Cody, Baumgart, Tobias, Reed, Ellen H., Hammer, Daniel A., Shinoda, Wataru, Klein, Michael L., Percec, Virgil·2017·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1708380114

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Abstract

Significance: Janus particles (JPs) are structures with two distinct faces. This study reports the discovery of an unprecedented class of JPs denoted Janus dendrimersomes (JDSs) coassembled from amphiphilic Janus dendrimers (JDs) with fluorinated, hydrogenated, and hybrid fluorinated–hydrogenated hydrophobic chains. JDSs consist of fluorinated and hydrogenated vesicles connected in a dumbbell-like shape. They appear as one structure in a broader fission-like pathway, which is revealed by varying the ratios of the three JD components. This pathway implies that non–protein-mediated fission and fusion is a likely mechanism by which similar structures form in synthetic and biological systems. These results highlight the potential importance of non–protein-mediated fusion and fission for biology and medicine.

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Authors: Xiao, Q., Sherman, S. E., Wilner, S. E., Zhou, X., Dazen, C., Baumgart, T., Reed, E. H., Hammer, D. A., Shinoda, W., Klein, M. L., & Percec, V.
Venue: Proceedings of the National Academy of Sciences
Publisher: Proceedings of the National Academy of Sciences
Published: 2017-08-07
Volume: 114
Issue: 34
Pages: E7045-E7053
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1708380114
OpenAlex: W2743443266
Cited by: 170
References: 4
FWCI: 12.98
Type: journal article
Language: en
Open access: bronze
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 184 d)
Funders: NSF | MPS | Division of Materials Research (1120901, 1066116)
Foundation for the National Institutes of Health (R01 GM097552)
HHS | NIH | National Institute of General Medical Sciences (GM081259-09)

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The paper: Xiao, Q., Sherman, S. E., Wilner, S. E., Zhou, X., Dazen, C., Baumgart, T., Reed, E. H., Hammer, D. A., Shinoda, W., Klein, M. L., & Percec, V. (2017). Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1708380114

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Janus dendrimersomes coassembled from fluorinated, hydrogenated, and hybrid Janus dendrimers as models for cell fusion and fission

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