The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides
Open accessAbstract
Significance: Clinical treatment of Helicobacter pylori using combination therapy is greatly challenged by the undesired killing of commensal bacteria and progressive development of drug resistance. To address these issues, we developed pH-sensitive, helix–coil conformation transitionable, antimicrobial polypeptides as a single therapeutic agent to selectively kill H. pylori under acidic condition in the stomach with minimal toxicity to commensal bacteria and diminished drug resistance. Through the control of the secondary structure transition, the polypeptides showed unappreciable toxicity to commensal bacteria and tissues at physiological pH when they adopted random coiled conformation, while the restoration of helical structure in the acidic stomach allowed the polypeptide to regain membrane disruptive capability to effectively and selectively kill H. pylori , including drug-resistant strains.
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Cites
The gut microbiota shapes intestinal immune responses during health and disease
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Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., et al. (2015) · Science · doi:10.1126/science.aad1329 · Cited by 3,488
Role of the gut microbiota in immunity and inflammatory disease
Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256
Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
Perry, R. J., Peng, L., Barry, N. A., Cline, G. W., Zhang, D., Cardone, R. L., Petersen, K. F., Kibbey, R. G., Goodman, A. L., & Shulman, G. I. (2016) · Nature · doi:10.1038/nature18309 · Cited by 1,299
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
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Cited by
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
Jiang, Y., Chen, Y., Song, Z., Tan, Z., & Cheng, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.016 · Cited by 267
Self-citationBioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management
Zhang, C. Y., Gao, J., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201803618 · Cited by 222
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Metadata
- Authors
- Xiong, M., Bao, Y., Xu, X., Wang, H., Han, Z., Wang, Z., Liu, Y., Huang, S., Song, Z., Chen, J., Peek, R. M., Yin, L., Chen, L.-F., & Cheng, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-11-13
- Volume
- 114
- Issue
- 48
- Pages
- 12675-12680
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2769799079
- Cited by
- 168
- References
- 7
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiong, M., Bao, Y., Xu, X., Wang, H., Han, Z., Wang, Z., Liu, Y., Huang, S., Song, Z., Chen, J., Peek, R. M., Yin, L., Chen, L.-F., & Cheng, J. (2017). Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1710408114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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