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Cited by 584

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB

Open access
Gong, Guozhong, Waris, Gulam, Tanveer, Rasheeda, Siddiqui, Aleem·2001·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.171311298
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Abstract

The nonstructural protein 5A (NS5A) encoded by the human hepatitis C virus RNA genome is shown here to induce the activation of NF-κB and STAT-3 transcription factors from its cytoplasmic residence via oxidative stress. NS5A causes the disturbance of intracellular calcium. Ca 2+signaling triggers the elevation of reactive oxygen species in mitochondria, leading to the translocation of NF-κB and STAT-3 into the nucleus. Evidence is presented for the constitutive activation of STAT-3 by NS5A. In the presence of antioxidants [pyrrolidine dithiocarbamate (PDTC), N-acetyl l-cysteine (NAC)] or Ca 2+chelators (EGTA-AM, TMB-8), NS5A-induced activation of NF-κB and STAT-3 was eliminated. These results provide an insight into the mechanism by which NS5A can alter intracellular events relevant to liver pathogenesis associated with the viral infection.

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Metadata

Authors
Gong, G., Waris, G., Tanveer, R., & Siddiqui, A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2001-07-31
Volume
98
Issue
17
Pages
9599-9604
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.171311298
OpenAlex
W2082933842
Cited by
584
References
38
FWCI
17.28
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB. https://app.cochat.ai/papers/10.1073/pnas.171311298
The paper
Gong, G., Waris, G., Tanveer, R., & Siddiqui, A. (2001). Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-κB. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.171311298

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.