The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A new recommended dietary allowance of vitamin C for healthy young women
Open accessAbstract
The recently released Recommended Dietary Allowance of vitamin C for women, 75 mg daily, was based on data for men. We now report results of a depletion-repletion study with healthy young women hospitalized for 186 +/- 28 days, using vitamin C doses of 30-2,500 mg daily. The relationship between dose and steady-state plasma concentration was sigmoidal. Only doses above 100 mg were beyond the linear portion of the curve. Plasma and circulating cells saturated at 400 mg daily, with urinary elimination of higher doses. Biomarkers of endogenous oxidant stress, plasma and urine F(2)-isoprostanes, and urine levels of a major metabolite of F(2)-isoprostanes were unchanged by vitamin C at all doses, suggesting this vitamin does not alter endogenous lipid peroxidation in healthy young women. By using Food and Nutrition Board guidelines, the data indicate that the Recommended Dietary Allowance for young women should be increased to 90 mg daily.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Multiple studies showed no effect of vitamin C on markers of lipid peroxidation in healthy humans or animals [63,66,166].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [66]
The cited source says what the claim attributes to it.
In the citing paper
“The plasma levels increase to this plateau concentration up to doses of about 200–400 mg daily. Higher doses increase plasma levels only minimally [55,65,66].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [66]
The cited source says what the claim attributes to it.
In the citing paper
“This was not confirmed in women where the saturable doses were 200–400 mg daily, matching with doses producing maximal steady-state plasma levels [66].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325
A family of mammalian Na+-dependent L-ascorbic acid transporters
Tsukaguchi, H., Tokui, T., Mackenzie, B., Berger, U. V., Chen, X.-Z., Wang, Y., Brubaker, R. F., & Hediger, M. A. (1999) · Nature · doi:10.1038/19986 · Cited by 882
Nonparametric Statistical Methods
Ziegel, E. R., Hollander, M., & Wolfe, D. A. (1999) · Technometrics · doi:10.2307/1271371 · Cited by 613
Khaw, K., Bingham, S. A., Welch, A. A., Luben, R., Wareham, N. J., Oakes, S., & Day, N. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04128-3 · Cited by 576
Criteria and recommendations for vitamin C intake
Levine, M. (1999) · JAMA · doi:10.1001/jama.281.15.1415 · Cited by 559
Self-citationNon-parametric Statistical Methods
Gastwirth, J. L. (1990) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-20865-4_24 · Cited by 516
Urinary prostaglandins. Identification and origin.
Frölich, J. C., Wilson, T. W., Sweetman, B. J., Smigel, M. D., Nies, A. S., Carr, K., Watson, J. T., & Oates, J. A. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107987 · Cited by 478
Yates, A. A., Schlicker, S. A., & Suitor, C. W. (1998) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(98)00160-6 · Cited by 422
Morrow, J. D., & Roberts, L. J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)00106-8 · Cited by 409
Micronutrients prevent cancer and delay aging
Ames, B. N. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00269-0 · Cited by 347
Research works printed but not linked: 4
- Vitamin C 5, 95–185 (2000).
- Referenzwerte für die Nahrstoffzefuhr (Recommended Values for Nutritional Intake) (Umschau, Frankfurt), pp. 137–144, 2000).
- Recommended Dietary Allowances (Dietary Reference Intakes) (Daiichi Shuppan, Tokyo), pp. 112–127 (2000).
- L Birlouez-Aragon, B Fieux, G Potier de Courcy, C Hercberg Apports Nutritionnels Conseillés pour la Population Française (Editions TEC and Doc, 3rd Ed., London), pp. 215–230 (2000).
Cited by
Sorted by citations
Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238
Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075
Metadata
- Authors
- Levine, M., Wang, Y., Padayatty, S. J., & Morrow, J.
- Affiliations
- National Institutes of Health (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-08-14
- Volume
- 98
- Issue
- 17
- Pages
- 9842-9846
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC55540
- OpenAlex
- W2070532527
- Cited by
- 496
- References
- 27
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 12 · 2023: 21 · 2022: 30 · 2021: 34 · 2020: 38 · 2019: 17 · 2018: 17 · 2017: 17 · 2016: 11 · 2015: 17 · 2014: 19 · 2013: 27 · 2012: 25
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK 48831, DK 26657, GM 15431, CA 77839)
- National Cancer Institute (CA77839, P01CA077839)
- National Institute of General Medical Sciences (GM 15431, P50GM015431, P01GM015431)
- National Institute of Diabetes and Digestive and Kidney Diseases (Z01DK054506, DK-26657, DK 48831, P30DK026657, R01DK048831)
- NIH Clinical Center
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin C, RDA, young women, dose-response relationship, steady-state plasma concentration, urinary excretion, F2-isoprostanes, lipid peroxidation, oxidative stress
- MeSH terms
- Adult, Ascorbic Acid, Biological Availability, Canada, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Female, Humans, Nutritional Requirements, Sex Characteristics, United States, Lipid Peroxidation, Dinoprost, Oxidative Stress, Nutrition Policy, F2-Isoprostanes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
