Origin of slow spontaneous resting-state neuronal fluctuations in brain networks
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Abstract
Significance: Resting-state infra-slow brain activity fluctuations are observed across various cognitive and disease brain states. Although resting-state fluctuations have received a great deal of interest over the past few years, the underlying biophysical mechanisms are not known. Using computational modeling, we show that spontaneous resting-state fluctuations arise from dynamic ion concentrations and are influenced by the Na + /K + pump, glial K + buffering, and AMPA/GABA synaptic currents. These findings provide insights into the biophysical mechanisms underlying generation of this phenomenon and may lead to better understanding of how different cognitive or disease states influence resting-state activity.
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Electrophysiological infraslow fluctuations are putatively engendered by a combination of neuronal and glial currents.
“Putatively engendered by a combination of neuronal and glial currents [63, 68, 71–76], eISFs have been shown in both cortical [65, 66, 77] and subcortical [76, 78–82] tissues”
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- Authors
- Krishnan, G. P., González, O. C., & Bazhenov, M.
- Affiliations
- University of California San Diego (US)
- Department of Medicine, University of California, San Diego, La Jolla, CA 92093;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-06-08
- Volume
- 115
- Issue
- 26
- Pages
- 6858-6863
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6042137
- OpenAlex
- W2950279742
- Cited by
- 73
- References
- 63
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 4 · 2023: 11 · 2022: 8 · 2021: 11 · 2020: 12 · 2019: 8 · 2018: 3
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- DOD | United States Navy | Office of Naval Research (N000141612829)
- National Science Foundation (DGE-1326120)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Na+/K+-ATPase, biophysical mechanisms, brain networks, computational modeling
- MeSH terms
- K Cl- Cotransporters, Sodium-Potassium-Exchanging ATPase, Brain, Computer Simulation, gamma-Aminobutyric Acid, Humans, Models, Neurological, Nerve Net, Synaptic Transmission, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Symporters
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