Cited by 670Functional Brain Connectivity StudiesNeural dynamics and brain functionSleep and Wakefulness Research

Electrophysiological correlates of the brain's intrinsic large-scale functional architecture

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He, Biyu J., Snyder, Abraham Z., Zempel, John M., Smyth, Matthew D., Raichle, Marcus E.·2008·Proceedings of the National Academy of Sciences

Abstract

Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.

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Authors
He, B. J., Snyder, A. Z., Zempel, J. M., Smyth, M. D., & Raichle, M. E.
Affiliations
  • Departments of *Radiology,
  • Neurology,
  • Neurosurgery,
  • Washington University in St. Louis (US)
Venue
Proceedings of the National Academy of Sciences
Published
2008-10-14
Volume
105
Issue
41
Pages
16039-16044
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2106532504
Cited by
670
References
38
Citations by year
2026: 9 · 2025: 17 · 2024: 35 · 2023: 24 · 2022: 16 · 2021: 37 · 2020: 33 · 2019: 38 · 2018: 49 · 2017: 42 · 2016: 45 · 2015: 48 · 2014: 43 · 2013: 67 · 2012: 56
FWCI
19.12
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (NS06833)
  • National Institute of Neurological Disorders and Stroke (P50NS006833, NS 06833)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
slow cortical potentials, electrocorticography, gamma power, large-scale brain networks, intrinsic brain activity, slow-wave sleep, REM sleep, wakefulness
MeSH terms
Action Potentials, Brain, Brain Mapping, Electrophysiology, Epilepsy, Humans, Magnetic Resonance Imaging, Membrane Potentials, Sleep, Sleep, REM, Wakefulness

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