Mistimed sleep disrupts circadian regulation of the human transcriptome
Open accessAbstract
Significance: Disruption of the timing of the sleep–wake cycle and circadian rhythms, such as occurs during jet lag and shift work, leads to disordered physiological rhythms, but to what extent the molecular elements of circadian rhythm generation are affected is not known. Here, we show that delaying sleep by 4 h for 3 consecutive days leads to a sixfold reduction of circadian transcripts in the human blood transcriptome to just 1%, whereas, at the same time, the centrally driven circadian rhythm of melatonin is not affected. Genes and processes affected included those at the core of circadian rhythm generation and gene expression. The data have implications for understanding the negative health outcomes of disruption of the sleep–wake cycle.
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Sleep restriction changes the circadian rhythm of genes associated with immune and inflammatory responses, and these perturbances in rhythmicity are likely to be associated with health problems related to sleep disturbances.
“In addition, sleep restriction has been found to change the circadian rhythm of genes associated with immune and inflammatory responses; these perturbances in rhythmicity are likely to be also associated with health problems related to sleep disturbances (15, 387)”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [15]
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“Here, we address the question of whether the molecular processes that regulate circadian gene expression are also affected when the synchrony of the sleep–wake cycle and endogenous circadian rhythmicity is disrupted, such as occurs during jet lag and shift work (16) and laboratory protocols of forced desynchrony (17,…”
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Self-citation
- Authors
- Archer, S. N., Laing, E. E., Möller-Levet, C. S., van der Veen, D. R., Bucca, G., Lazar, A. S., Santhi, N., Slak, A., Kabiljo, R., von Schantz, M., Smith, C. P., & Dijk, D.-J.
- Affiliations
- University of Surrey (GB)
- Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-01-21
- Volume
- 111
- Issue
- 6
- Pages
- E682-91
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3926083
- OpenAlex
- W1508670761
- Cited by
- 386
- References
- 61
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 31 · 2023: 33 · 2022: 26 · 2021: 30 · 2020: 23 · 2019: 42 · 2018: 39 · 2017: 33 · 2016: 26 · 2015: 39 · 2014: 25 · 2013: 1
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Brighton Repository (University of Brighton) (publishedVersion, other-oa)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/F022883/1, BB/F022883)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- circadian rhythm, transcriptome, circadian gene expression, sleep-wake cycle, circadian desynchrony, chromatin modification, clock genes, Bmal1, RNA polymerase II, translation (biology), cold-inducible RNA-binding protein, blood transcriptome, shift work, jet lag
- MeSH terms
- Adult, Circadian Rhythm, Female, Humans, Male, Melatonin, RNA, Messenger, Sleep, Gene Expression, Young Adult, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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